Cancer chemoprevention with the adrenocortical steroid dehydroepiandrosterone and structural analogs

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.

1990 • 402 citations

The Effects of Oral Dehydroepiandrosterone on Endocrine-Metabolic Parameters in Postmenopausal Women*

1990 • 315 citations

Therapeutic Effects of Dehydroepiandrosterone (DHEA) in Diabetic Mice

1982 • 291 citations

Dehydroepiandrosterone enhances IL2 production and cytotoxic effector function of human T cells

1991 • 275 citations

Nutrition in Relation to Cancer.

1948 • 256 citations

Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury.

1988 • 241 citations

Prevention of obesity in A^vy/a mice by dehydroepiandrosterone

1977 • 231 citations

Inhibition of spontaneous breast cancer formation in female C3H(Avy/a) mice by long-term treatment with dehydroepiandrosterone.

1979 • 223 citations

Modulation of growth, differentiation and carcinogenesis by dehydroepiandrosterone

1987 • 159 citations

Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone.

1985 • 148 citations

Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production

1992 • 132 citations

Dehydroepiandrosterone and Structural Analogs: A New Class of Cancer Chemopreventive Agents

1988 • 130 citations

Hormones, thermogenesis, and obesity

1989 • 128 citations

Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone

1984 • 125 citations

Inhibition of 7,12-dimethylbenz[a]anthracene- and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone

1981 • 123 citations

Specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase

1970 • 100 citations

Fluocinolone acetonide: A potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis

1977 • 93 citations

Reversal of food restriction-induced inhibition of mouse skin tumor promotion by adrenalectomy

1992 • 89 citations

Hepatocarcinogenicity of dehydroepiandrosterone in the rat.

1992 • 87 citations

Mechanism of inhibition of growth of 3T3-L1 fibroblasts and their differentiation to adipocytes by dehydroepiandrosterone and related steroids: role of glucose-6-phosphate dehydrogenase.

1989 • 87 citations

Dehydroepiandrosterone (DHEA) and 3β-methylandrost-5-en-17-one: inhibitors of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin papilloma formation in mice

1984 • 77 citations

Inhibition of rat mammary gland chemical carcinogenesis by dietary dehydroepiandrosterone or a fluorinated analogue of dehydroepiandrosterone.

1991 • 75 citations

SOME PHYSIOLOGICAL EFFECTS ASSOCIATED WITH CHRONIC CALORIC RESTRICTION

1948 • 73 citations

Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats

1986 • 65 citations

Protective effect of dehydroepiandrosterone against aflatoxin B1-and 7,12-dimethylbenz(a)anthracene-induced cytotoxicity and transformation in cultured cells.

1975 • 63 citations

Novel dehydroepiandrosterone analogues with enhanced biological activity and reduced side effects in mice and rats.

1988 • 60 citations

Initiation of Precocious Sexual Maturation in the Immature Rat Treated with Dehydroepiandrosterone¹

1975 • 58 citations

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin papillomas and carcinomas by dehydroepiandrosterone and 3-beta-methylandrost-5-en-17-one in mice.

1985 • 55 citations

The enzymatic basis for production by human neutrophils

1982 • 54 citations

Inhibition of growth of HeLa and WI-38 cells by dehydroepiandrosterone and its reversal by ribo- and deoxyribonucleosides

1986 • 51 citations

Nutrition as a modulator of the aging process.

1984 • 50 citations

Dehydroepiandrosterone and 16α-Br-epiandrosterone inhibit 12-O-tetradecanoylphorbol-13-acetate stimulation of superoxide radical production by human polymorphonuclear leukocytes

1985 • 48 citations

Reversal by ribo- and deoxyribonucleosides of dehydroepiandrosterone-induced inhibition of enzyme altered foci in the liver of rats subjected to the initiation-selection process of experimental carcinogenesis

1988 • 47 citations

Inhibition of 7,12-dimethylbenz[a]anthracene-initiated and 12-O-tetradecanoylphorbol-13-acetate-promoted skin papilloma formation in mice by dehydroepiandrosterone and two synthetic analogs

1989 • 43 citations

Inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted skin tumor formation in mice by 16α-fluoro-5-androsten-17-one and its reversal by deoxyribonucleosides

1991 • 36 citations

Inhibition of Proteinuria Development in Aging Sprague-Dawley Rats and C57BL/6 Mice by Long-Term Treatment with Dehydroepiandrosterone

1986 • 35 citations

Phenotypic modulation of hepatocarcinogenesis and reduction in N-nitrosomorpholine-induced hemangiosarcoma and adrenal lesion development in Sprague-Dawley rats by dehydroepiandrosterone

1988 • 34 citations

Protection of a rat tracheal epithelial cell line from paraquat toxicity by inhibition of glucose-6-phosphatedehydrogenase

1993 • 24 citations

Modulatory Mechanisms of Chemical Carcinogenesis: The Role of the NADPH Pool in the Benzo(a)pyrene Activation

1984 • 22 citations

A permeabilized cell system for studying regulation of aryl hydrocarbon hydroxylase: NADPH as rate limiting factor in benzo(a)pyrene metabolism

1985 • 20 citations

THE BIOLOGICAL SIGNIFICANCE OF DEHYDROEPIANDROSTERONE

1990 • 8 citations