Theoretical studies of clonal selection: Minimal antibody repertoire size and reliability of self-non-self discrimination

Statistical Theory of Reliability and Life Testing-Probability Models

1977 • 3,813 citations

Mathematical Theory of Reliability

1966 • 2,801 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Reliable circuits using less reliable relays

1956 • 715 citations

IMMUNOGLOBULINS ON THE SURFACE OF LYMPHOCYTES

1971 • 665 citations

Studies in the Philosophy of Biology

1974 • 567 citations

Theoretical Immunology

1980 • 345 citations

Immunological Specificity

1959 • 270 citations

Idiotype suppression. I. Influence of the dose and of the effector functions of anti‐idiotypic antibody on the production of an idiotype

1974 • 249 citations

Mathematical Theory of Reliability.

1966 • 246 citations

The Nature of an Antigenic Determinant

1966 • 217 citations

On the Specificity of Antibodies

1975 • 217 citations

Specific Inhibition of Plaque Formation to Phosphorylcholine by Antibody against Antibody

1972 • 200 citations

Antigens, Lymphoid Cells and the Immune Response

1971 • 200 citations

Cellular selection and regulation in the immune response

1975 • 198 citations

The Histocompatibility-Linked Immune Response Genes

1975 • 186 citations

Reliable circuits using less reliable relays

1956 • 172 citations

The immune system: Genes, receptors, signals

1973 • 169 citations

Binding of 2,4-dinitrophenyl compounds and other small molecules to a crystalline .lambda.-type Bence-Jones dimer

1974 • 164 citations

The Neurosciences: Paths of Discovery

1976 • 139 citations

Major Transplantation Antigens, Viruses, and Specificity of Surveillance T Cells

1977 • 135 citations

Immunity in evolution

1977 • 122 citations

GENETIC CONTROL OF IMMUNE RESPONSES IN VITRO

1973 • 108 citations

ISOLATION OF ANTIGEN-BINDING CELLS FROM UNPRIMED MICE

1974 • 90 citations

The Frequency of Phosphorylcholine-Specific B Cells in Conventional and Germfree Balb/c Mice

1975 • 79 citations

REQUIREMENTS FOR PROLONGED SUPPRESSION OF AN IDIOTYPIC SPECIFICITY IN ADULT MICE

1973 • 78 citations

Frequency of hapten‐specific B cells in neonatal and adult murine spleens

1974 • 73 citations

ANTIGEN BINDING AND CAPPING BY LYMPHOCYTES OF GENETIC NONRESPONDER MICE

1972 • 62 citations

Antigens, lymphoid cells, and the immune response

1971 • 60 citations

Frequency of precursor cells against the enzyme β‐galactosidase An estimate of the BALB/c strain antibody repertoire

1976 • 53 citations

Antibody cell daughters can produce antibody of different specificities

1974 • 53 citations

PHYLOGENY OF IMMUNOGLOBULIN STRUCTURE AND FUNCTION

1970 • 49 citations

Molecular Approaches to Immunology

1975 • 47 citations

Fourier analysis of bivalve outlines: Implications on evolution and autecology

1976 • 40 citations

The Generation of Antibody Diversity: Its Dependence on Antigenic Stimulation

1974 • 37 citations

Generation of antibody diversity. I. Kinetics of production of different antibody specificities during the course of an immune response

1974 • 36 citations

Mapping of dihydrofolate-reductase receptor site by correlation with minimal topological (steric) differences

1977 • 34 citations

Mathematical models in molecular and cellular biology

1984 • 30 citations

Enzyme-substrate recognition

1978 • 18 citations

The generation of antibody diversity. II. Plaque morphology as a simple marker for antibody specificity at the single‐cell level

1974 • 18 citations

Genetic Control of the Immune Response of Inbred Guinea Pigs to 2,4-Dinitrophenyl Guinea Pig Albumin. Frequency of Antigen-Binding Lymphocytes and Avidity of Antibodies Secreted by Plaque-Forming Cells

1972 • 15 citations

A computer program for comparing irregular two-dimensional forms

1977 • 11 citations