Fluorocitrate and fluoroacetate effects on astrocyte metabolism in vitro

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A Flexible System of Enzymatic Analysis

1972 • 4,133 citations

Glutamine Synthetase: Glial Localization in Brain

1977 • 1,170 citations

Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury

1993 • 694 citations

Pyruvate car☐ylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools

1985 • 462 citations

Role of glial cells in the regulation of the brain ion microenvironment

1989 • 448 citations

Effects of Changes in Brain Metabolism on the Levels of Citric Acid Cycle Intermediates

1966 • 396 citations

Metabolic Fate of ¹⁴C‐Labeled Glutamate in Astrocytes in Primary Cultures

1982 • 287 citations

An In Vivo Model for Studying Function of Brain Tissue Temporarily Devoid of Glial Cell Metabolism: The Use of Fluorocitrate

1987 • 253 citations

Glial Glycogen Stores Affect Neuronal Survival during Glucose Deprivation in vitro

1993 • 233 citations

Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons

1993 • 219 citations

Selective inhibition of glial cell metabolism in vivo by fluorocitrate

1992 • 206 citations

Physiologic coupling of glial glycogen metabolism to neuronal activity in brain

1992 • 204 citations

First direct demonstration of preferential release of citrate from astrocytes using [13C]NMR spectroscopy of cultured neurons and astrocytes

1991 • 156 citations

Role of Glial Cells for the Basal and Ca²⁺‐Dependent K⁺‐Evoked Release of Transmitter Amino Acids Investigated by Microdialysis

1989 • 152 citations

Fluoroacetate and fluorocitrate: Mechanism of action

1991 • 145 citations

α‐Ketoglutarate and Malate Uptake and Metabolism by Synaptosomes: Further Evidence for an Astrocyte‐to‐Neuron Metabolic Shuttle

1984 • 143 citations

Acetate and fluoroacetate as possible markers for glial metabolism in vivo

1986 • 139 citations

HIGH AFFINITY UPTAKE OF L‐GLUTAMATE AND L‐ASPARTATE BY GLIAL CELLS

1977 • 132 citations

Tricarboxylic acid-cycle metabolism in brain. Effect of fluoroacetate and fluorocitrate on the labelling of glutamate aspartate, glutamine and γ-amino butyrate

1970 • 117 citations

Astrocyte glutamate uptake during chemical hypoxia in vitro

1992 • 116 citations

Mechanism of the Toxicity of the Active Constituent of Dichapetalum Cymosum and Related Compounds

1957 • 109 citations

Influence of Pathological Concentrations of Ammonia on Metabolic Fate of ¹⁴C‐Labeled Glutamate in Astrocytes in Primary Cultures

1984 • 102 citations

Importance of Glutamine for γ‐Aminobutyric Acid Synthesis in Rat Neostriatum In Vivo

1988 • 87 citations

Energy metabolism at the cellular level of the CNS

1992 • 83 citations

Glucose Can Fuel Glutamate Uptake in Ischemic Brain

1994 • 81 citations

Carbon Dioxide Fixation in Neuronal and Astroglial Cells in Culture

1992 • 78 citations

Regulation of Glycogen Content in Primary Astrocyte Culture: Effects of Glucose Analogues, Phenobarbital, and Methionine Sulfoximine

1989 • 70 citations

Glutamate uptake and glutamate content in primary cultures of mouse astrocytes during anoxia, substrate deprivation and simulated ischemia under normothermic and hypothermic conditions

1993 • 64 citations

Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system

1992 • 64 citations

Increase in the stimulation-induced overflow of glutamate by fluoroacetate, a selective inhibitor of the glial tricarboxylic cycle

1987 • 62 citations

Dibutyryl Cyclic AMP Treatment of Astrocytes in Primary Cultures as a Substitute for Normal Morphogenic and ‘Functiogenic’ Transmitter Signals

1990 • 61 citations

Molecular Aspects of Development and Aging of the Nervous System

1989 • 58 citations

Changes in evoked potentials and amino acid content during fluorocitrate action studied in rat hippocampal cortex

1993 • 48 citations

Seizures induced by fluoroacetic acid and fluorocitric acid may involve chelation of divalent cations in the spinal cord

1990 • 47 citations

Glial localization of adenylate-cyclase-coupled β-adrenoreceptors in rat forebrain slices

1990 • 40 citations

Endogenous extracellular glutamate accumulation in rat neocortical cultures by reversal of the transmembrane sodium gradient

1992 • 40 citations

Effects of chronic exposure to ammonia on glutamate and glutamine interconversion and compartmentation in homogeneous primary cultures of mouse astrocytes

1994 • 38 citations

Enzymatic formation of glutathione-citryl thioester by a mitochondrial system and its inhibition by (-)erythrofluorocitrate

1977 • 36 citations

The effect of fluorocitrate on transmitter amino acid release from rat striatal slices

1988 • 29 citations

Control of aerobic glycolysis in the brain in vitro

1980 • 28 citations

Metabolism of Glutamate and Glutamine in Neurons and Astrocytes in Primary Cultures

2018 • 27 citations

Effects of fluoroacetate and fluorocitrate on the metabolic compartmentation of tricarboxylic acid cycle in rat brain slices

1972 • 25 citations

Gliotoxin-induced suppression of ocular dominance plasticity in kitten visual cortex

1993 • 25 citations

Glycolysis can prevent non-synaptic excitatory amino acid release during hypoxia

1994 • 23 citations

Studies on the cellular localization of biochemical responses to catecholamines in the brain

1992 • 22 citations

SOME NEUROCHEMICAL ASPECTS OF FLUOROCITRATE INTOXICATION

1971 • 16 citations

Astrocytes and the entry of circulating ammonia into the brain: Effect of fluoroacetate

1993 • 15 citations

Effect of pH on Glutamine Content Derived from Exogenous Glutamate in Astrocytes

1992 • 15 citations

Increase in the stimulation-induced overflow of excitatory amino acids from hippocampal slices: Interaction between low glucose concentration and fluoroacetate

1988 • 14 citations

Temporary impairment of Müller cell metabolism in the rat retina by intravitreal injection of fluorocitrate

1991 • 12 citations

Glucose-supported oxidative metabolism and evoked potentials are sensitive to fluoroacetate, an inhibitor of glial tricar☐ylic acid cycle in the olfactory cortex slice

1990 • 11 citations

Multiunits in the mesencephalic reticular formation: ontogenetic development of wakefulness and sleep cycle in the rat.

1980 • 7 citations