Regulation of secondary metabolism and cell differentiation in Streptomyces: A-factor as a microbial hormone and the AfsR protein as a component of a two-component regulatory system

Protein phosphorylation and regulation of adaptive responses in bacteria

1989 • 1,495 citations

Genetics of industrial microorganisms

1978 • 200 citations

Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor.

1982 • 186 citations

Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius

1992 • 167 citations

Gene cluster for streptomycin biosynthesis inStreptomyces griseus: nucleotide sequence of three genes and analysis of transcriptional activity

1987 • 165 citations

Cloning of a pleiotropic gene that positively controls biosynthesis of A-factor, actinorhodin, and prodigiosin in Streptomyces coelicolor A3(2) and Streptomyces lividans

1983 • 153 citations

Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2)

1990 • 137 citations

[The A-factor, responsible for streptomycin biosynthesis by mutant strains of Actinomyces streptomycini].

1967 • 132 citations

Unstable genetic determinant of A-factor biosynthesis in streptomycin-producing organisms: cloning and characterization

1984 • 132 citations

Mutations in a new Streptomyces coelicolor locus which globally block antibiotic biosynthesis but not sporulation

1990 • 106 citations

Streptomycin biosynthesis and its regulation in Streptomycetes

1992 • 102 citations

Detection and properties of A-factor-binding protein from Streptomyces griseus

1989 • 89 citations

The A-factor-binding protein of Streptomyces griseus negatively controls streptomycin production and sporulation

1990 • 89 citations

Identification of an A-factor-dependent promoter in the streptomycin biosynthetic gene cluster of Streptomyces griseus

1991 • 67 citations

Autoregulatory Factors of Secondary Metabolism and Morphogenesis in Actinomycetes

1990 • 66 citations

Phosphorylation of the AfsR product, a global regulatory protein for secondary-metabolite formation in Streptomyces coelicolor A3(2)

1991 • 62 citations

Nucleotide sequence and transcriptional analysis of the Streptomyces griseus gene (afsA) responsible for A-factor biosynthesis

1989 • 59 citations

afsB stimulates transcription of the actinorhodin biosynthetic pathway in Streptomyces coelicolor A3(2) and Streptomyces lividans

1989 • 57 citations

Production in large quantities of actinorhodin and undecylprodigiosin induced by afsB in Streptomyces lividans.

1984 • 41 citations

Production in Large Quantities of Actinorhodin and Undecyl-prodigiosin Induced by afsB in Streptomyces lividans

1984 • 40 citations

The cloned Streptomyces bikiniensis A-factor determinant.

1985 • 25 citations