Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

THE PHENOMENON OF THE ACUTE PHASE RESPONSE*

1982 • 1,498 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

pEMBL: a new family of single stranded plasmids

1983 • 1,231 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Altering gene expression with 5-azacytidine

1985 • 408 citations

Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro.

1986 • 398 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells

1984 • 365 citations

New versatile cloning and sequencing vectors based on bacteriophage M13

1983 • 263 citations

Tissue-specific expression is conferred by a sequence from the 5′ end of the rat albumin gene.

1984 • 202 citations

Cell-specific expression of a transfected human α1-antitrypsin gene

1985 • 188 citations

Molecular Biology of DNA Methylation

1985 • 186 citations

Structure and expression of the genes coding for human alpha 1-acid glycoprotein.

1987 • 182 citations

Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene.

1987 • 178 citations

Determinants of Rat Albumin Promoter Tissue Specificity Analyzed by an Improved Transient Expression System

1987 • 166 citations

α1-Acid Glycoprotein

1975 • 153 citations

Rat alpha 1-acid glycoprotein mRNA. Cloning of double-stranded cDNA and kinetics of induction of mRNA levels following acute inflammation.

1981 • 139 citations

Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells.

1987 • 138 citations

Regulation of major acute-phase plasma proteins by hepatocyte-stimulating factors of human squamous carcinoma cells.

1986 • 137 citations

The human haptoglobin gene: transcriptional regulation during development and acute phase induction.

1987 • 128 citations

Inducible and tissue-specific expression of human C-reactive protein in transgenic mice.

1987 • 127 citations

Species- and tissue-specific expression of human alpha 1-antitrypsin in transgenic mice.

1987 • 126 citations

Structure of the human α₁acid glycoprotein gene: sequence homology with other human acute phase protein genes

1985 • 118 citations

Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice

1987 • 117 citations

5-azacytidine permits gene activation in a previously noninducible cell type

1985 • 105 citations

Tissue-specific expression of the rat albumin gene: genetic control of its extinction in microcell hybrids.

1986 • 100 citations

Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5′-flanking region contains hepatoma specific transcriptional signals.

1985 • 93 citations

A genetic analysis of extinction: trans-regulation of 16 liver-specific genes in hepatoma-fibroblast hybrid cells.

1987 • 67 citations

The human alpha-1-antitrypsin gene is efficiently expressed from two tissue-specific promotors in transgenic mice

1987 • 56 citations

Integration and expression of genes introduced into mouse embryos

1987 • 16 citations