Mutational analysis of the angiotensin type 2 receptor: contribution of conserved amino acids in the region of the sixth transmembrane domain

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

Renin-angiotensin system: biochemistry and mechanisms of action.

1977 • 1,373 citations

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

1991 • 1,247 citations

Identification of angiotensin II receptor subtypes

1989 • 825 citations

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

1993 • 767 citations

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

1993 • 713 citations

[17]Gene splicing by overlap extension

1993 • 463 citations

Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research.

1991 • 393 citations

Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome

1992 • 299 citations

Cloning and expression of a novel angiotensin II receptor subtype.

1992 • 270 citations

Tetrazole and Carboxylate Groups of Angiotensin Receptor Antagonists Bind to the Same Subsite by Different Mechanisms

1995 • 172 citations

Identification of peptide binding residues in the extracellular domains of the AT1 receptor.

1994 • 168 citations

The Docking of Arg2 of Angiotensin II with Asp281 of AT1 Receptor Is Essential for Full Agonism

1995 • 156 citations

Quantitative Autoradiography Reveals Different Angiotensin II Receptor Subtypes in Selected Rat Brain Nuclei

1991 • 134 citations

Cloning of cDNA and Analysis of the Gene for Mouse Angiotensin II Type 2 Receptor

1993 • 127 citations

Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan

1994 • 127 citations

Mutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1)

1995 • 118 citations

Differentiation between binding sites for angiotensin II and nonpeptide antagonists on the angiotensin II type 1 receptors.

1994 • 117 citations

The ligand binding site of the angiotensin AT1 receptor

1996 • 103 citations

Biochemical Characterization of Two Angiotensin II Receptor Subtypes in the Rat

1990 • 94 citations

Synthesis of some analogs of angiotensin II as specific antagonists of the parent hormone

1972 • 76 citations

A computer modeling postulated mechanism for angiotensin II receptor activation

1995 • 70 citations

Molecular Cloning, Sequencing and Functional Expression of an Amphibian Angiotensin II Receptor

1993 • 63 citations

Disulfide bridges in extracellular domains of angiotensin II receptor type IA

1995 • 53 citations

Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor

1994 • 48 citations

Characterization of Binding Sites for the Angiotensin II Antagonist ¹²⁵I‐[Sarc¹,Ile⁸]‐Angiotensin II on Murine Neuroblastoma N1E‐115 Cells

1989 • 41 citations

Isolation and expression of a novel angiotensin II receptor from Xenopus laevis heart.

1993 • 41 citations

Mutational analysis of the angiotensin II type 2 receptor: contribution of conserved extracellular amino acids

1997 • 24 citations

Mutations in transmembrane segment VIJ of the AT₁ receptor differentiate between closely related insurmountable and competitive angiotensin antagonists

1994 • 24 citations

Factors that influence the antagonistic properties of angiotensin II antagonists

1973 • 23 citations

Role of the amino terminus in ligand binding for the angiotensin II type 2 receptor

1998 • 14 citations

Cloning and expression of angiotensin II type 2 (AT2) receptors from murine neuroblastoma N1E-115 cells: evidence for AT2 receptor heterogeneity

1997 • 14 citations

Mutation of a conserved fifth transmembrane domain lysine residue (Lys215) attenuates ligand binding in the angiotensin II type 2 receptor

1997 • 10 citations