Foundations of the use of an enzyme-kinetic analogy in cell-mediated cytotoxicity

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

A Note on the Kinetics of Enzyme Action

1925 • 1,279 citations

Natural Cell-mediated Immunity Against Tumors

1980 • 666 citations

Contactual lysis of antibody-coated chicken erythrocytes by purified lymphocytes

1970 • 363 citations

Destruction of Human Lymphoid Tissue-Culture Cell Lines by Human Peripheral Lymphocytes in 51Cr-Release Cellular Cytotoxicity Assays2

1974 • 183 citations

Quantitative analysis of the 51Cr release cytotoxicity assay for cytotoxic lymphocytes

1974 • 134 citations

Kinetic analysis of target cell destruction by effector T cells. I. Delineation of parameters related to the frequency and lytic efficiency of killer cells.

1976 • 117 citations

Mechanism of cell-mediated cytotoxicity at the single cell level. II. Evidence for first-order kinetics of T cell-mediated cytolysis and for heterogeneity of lytic rate.

1979 • 103 citations

Kinetic Analysis of Target Cell Destruction by Effector T Cells

1976 • 75 citations

Spontaneous cytotoxicity of cultured human cell lines mediated by normal peripheral blood lymphocytes. III. Kinetic parameters.

1978 • 58 citations

Cytotoxic activity of human lymphocytes: quanitative analysis of T cell and K cell cytotoxicity, revealing enzyme-like kinetics.

1977 • 58 citations

Modeling and Control in the Biomedical Sciences

1975 • 53 citations

Cytotoxic Activity of Human Lymphocytes: Quantitative Analysis of T Cell and K Cell Cytotoxicity, Revealing Enzyme-Like Kinetics

1977 • 51 citations

Mechanism of Cell-Mediated Cytotoxicity at the Single Cell Level

1979 • 47 citations

Spontaneous Cytotoxicity of Cultured Human Cell Lines Mediated by Normal Peripheral Blood Lymphocytes

1978 • 37 citations

Kinetic Analysis of Human Spontaneous Cell-Mediated Cytotoxicity

1979 • 34 citations

The Kinetics of Target Cell Lysis by Cytotoxic T Lymphocytes: A Description by Poisson Statistics

1978 • 21 citations

KINETIC ANALYSIS OF SPECIFICITY IN HUMAN NATURAL CELL-MEDIATED CYTOTOXICITY

1980 • 9 citations

QUANTITATION OF HUMAN NATURAL AND ANTIBODY-DEPENDENT CYTOTOXICITY11This work was supported in part by United States Public Health Service Grant AI-12766 from the National Institutes of Health.

1980 • 7 citations