Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Methods of enzymatic analysis

1964 • 5,230 citations

The determination of enzyme inhibitor constants

1953 • 4,050 citations

Carnitine--metabolism and functions

1983 • 1,620 citations

Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

1980 • 1,430 citations

THE SUBMITOCHONDRIAL LOCALIZATION OF MONOAMINE OXIDASE

1967 • 840 citations

CARNITINE

1988 • 610 citations

Regulation of gene expression by insulin

1996 • 543 citations

Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin.

1984 • 436 citations

CHARACTERISTICS OF ISOLATED AND PURIFIED PREPARATIONS OF THE OUTER AND INNER MEMBRANES OF MITOCHONDRIA*

1966 • 366 citations

Regulation of gene expression by insulin

1991 • 278 citations

The genes of hepatic glucose metabolism.

1990 • 271 citations

The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA

1981 • 250 citations

Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane.

1987 • 242 citations

Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function.

1993 • 219 citations

Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).

1993 • 190 citations

Insulin Regulates Transcription of the CCAAT/Enhancer Binding Protein (C/EBP) α , β , and δ Genes in Fully-differentiated 3T3-L1 Adipocytes

1995 • 157 citations

Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II.

1990 • 144 citations

Regulation of carnitine palmitoyltransferase by insulin results in decreased activity and decreased apparent Ki values for malonyl-CoA.

1987 • 128 citations

Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values.

1984 • 115 citations

Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat

1994 • 95 citations

Some differences in the properties of carnitine palmitoyltransferase activities of the mitochondrial outer and inner membranes

1987 • 94 citations

Phosphorylation of carnitine palmitoyltransferase and activation by glucagon in isolated rat hepatocytes

1985 • 91 citations

Peroxisomal fatty acid β-oxidation in HepG2 cells

1991 • 83 citations

<scp>l</scp>-carnitine acyltransferase in intact peroxisomes is inhibited by malonyl-CoA

1989 • 79 citations

Changes in Carnitine Palmitoyltransferase-I mRNA Abundance Produced by Hyperthyroidism and Hypothyroidism Parallel Changes in Activity

1994 • 77 citations

Alteration of the apparent Ki of carnitine palmitoyltransferase for malonyl-CoA by the diabetic state and reversal by insulin.

1985 • 72 citations

Evidence that the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA is an important site of regulation of hepatic fatty acid oxidation in the fetal and newborn rabbit. Perinatal development and effects of pancreatic hormones in cultured rabbit hepatocytes

1990 • 70 citations

Regulation of ketogenesis, gluconeogenesis and the mitochondrial redox state by dexamethasone in hepatocyte monolayer cultures

1986 • 61 citations

Malonyl-CoA-sensitive and -insensitive carnitine palmitoyltransferase activities of microsomes are due to different proteins

1994 • 53 citations

Re-evaluation of the interaction of malonyl-CoA with the rat liver mitochondrial carnitine palmitoyltransferase system by using purified outer membranes

1990 • 48 citations

The medium-chain carnitine acyltransferase activity associated with rat liver microsomes is malonyl-CoA sensitive

1990 • 47 citations

Activity of carnitine palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Selective modulation of mitochondrial enzyme activity by okadaic acid

1992 • 42 citations

Evidence for an impaired long‐chain fatty acid oxidation and ketogenesis in Fao hepatoma cells

1992 • 39 citations

Regulation of Ketogenesis, Gluconeogenesis, and Glycogen Synthesis by Insulin and Proinsulin in Rat Hepatocyte Monolayer Cultures

1986 • 37 citations

Regulatory Mechanism of Ketogenesis by Glucagon and Insulin in Isolated and Cultured Hepatocytes1

1982 • 37 citations

Proteinase treatment of intact hepatic mitochondria has differential effects on inhibition of carnitine palmitoyltransferase by different inhibitors

1992 • 36 citations

Evidence against direct involvement of phosphorylation in the activation of carnitine palmitoyltransferase by okadaic acid in rat hepatocytes

1994 • 34 citations

Dietary lipids coinduce xenobiotic metabolizing enzymes in rat liver

1993 • 31 citations

Myocardial carnitine palmitoyltransferase of the mitochondrial outer membrane is not altered by fasting

1992 • 29 citations

Cholate extracts of mitochondrial outer membranes increase inhibition by malonyl-CoA of carnitine palmitoyltransferase-I by a mechanism involving phospholipids

1994 • 28 citations

Okadaic acid stimulates carnitine palmitoyltransferase I activity and palmitate oxidation in isolated rat hepatocytes

1991 • 21 citations

Involvement of microsomal vesicles in part of the sensitivity of carnitine palmitoyltransferase I to malonyl-CoA inhibition in mitochondrial fractions of rat liver

1994 • 17 citations

Effects of starvation on the carnitine palmitoyltransferase of hepatic peroxisomes

1990 • 7 citations