Genetically Epilepsy‐Prone Rats (GEPRs) in Drug Research

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

1990 • 647 citations

Locus Coeruleus Lesions Suppress the Seizure‐Attenuating Effects of Vagus Nerve Stimulation

1998 • 534 citations

Epilepsy: A Comprehensive Textbook

1998 • 506 citations

Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy

1998 • 497 citations

Role of brain norepinephrine in audiogenic seizure in the rat.

1973 • 363 citations

Subcortical Structures and Pathways Involved in Convulsive Seizure Generation

1992 • 306 citations

Regional induction of fos immunoreactivity in the brain by anticonvulsant stimulation of the vagus nerve

1995 • 293 citations

A Review of the Preclinical Pharmacology of Tiagabine: A Potent and Selective Anticonvulsant GABA Uptake Inhibitor

1995 • 277 citations

Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats

1993 • 272 citations

Modification of seizure activity by electrical stimulation: III. Mechanisms

1972 • 270 citations

Exacerbation of Seizures in Children by Carbamazepine

1985 • 238 citations

Idiopathic generalized epilepsies : clinical, experimental and genetic aspects

1994 • 233 citations

ucb L059, a novel anti-convulsant drug: pharmacological profile in animais

1992 • 208 citations

Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy

1995 • 193 citations

A Noradrenergic and Serotonergic Hypothesis of the Linkage Between Epilepsy and Affective Disorders

1999 • 191 citations

Progress report on new antiepileptic drugs: a summary of the fourth Eilat conference (EILAT IV)

1999 • 178 citations

I. The genetically epilepsy-phone rat: An overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs

1986 • 166 citations

Kindling model of epilepsy.

1986 • 166 citations

Sound-induced seizures in serotonin 5-HT2c receptor mutant mice

1997 • 161 citations

Neurobiology of seizure predisposition in the genetically epilepsy-prone rat

1989 • 153 citations

EFFECT ON THE ELECTRO-ENCEPHALOGRAM OF DRUGS AND CONDITIONS WHICH INFLUENCE SEIZURES

1936 • 116 citations

Diphenylhydantoin activated seizures

1965 • 115 citations

Tricyclic antidepressant-induced seizures and plasma drug concentration.

1992 • 115 citations

Drugs for the Control of Epilepsy : Actions on Neuronal Networks Involved in Seizure Disorders

2019 • 109 citations

Regional Effects of Sodium Valproate on Extracellular Concentrations of 5‐Hydroxytryptamine, Dopamine, and Their Metabolites in the Rat Brain: An In Vivo Microdialysis Study

1992 • 100 citations

Global Increases in Seizure Susceptibility in Mice Lacking 5-HT2CReceptors: A Behavioral Analysis

1998 • 100 citations

Antidepressants and seizures: Clinical anecdotes overshadow neuroscience

1996 • 96 citations

A new drug for petit mal epilepsy

1958 • 94 citations

Anticonvulsant drugs and the genetically epilepsy-prone rat.

1985 • 94 citations

Evidence that carbamazepine and antiepilepsirine may produce a component of their anticonvulsant effects by activating serotonergic neurons in genetically epilepsy-prone rats.

1992 • 87 citations

Biphasic effects of zonisamide on serotonergic system in rat hippocampus

1999 • 86 citations

Neurochemical correlates of antiepileptic drugs in the genetically epilepsy-prone rat (GEPR)

1995 • 83 citations

Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.

1985 • 82 citations

Scope and contribution of genetic models to an understanding of the epilepsies.

1991 • 80 citations

GABA in the inferior colliculus plays a critical role in control of audiogenic seizures

1994 • 79 citations

Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats

1997 • 79 citations

Carbamazepine increases extracellular serotonin concentration: lack of antagonism by tetrodotoxin or zero Ca2+

1997 • 78 citations

Noradrenergic abnormalities in the genetically epilepsy-prone rat

1994 • 73 citations

Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: dose response relationships

1997 • 72 citations

Developing Genetically Epilepsy‐Prone Rats Have an Abnormal Seizure Response to Flurothyl

1989 • 70 citations

Idiopathic generalized epilepsies

1995 • 70 citations

Electroshock- and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats (GEPRs): differences in threshold and pattern

1990 • 68 citations

Periaqueductal gray neurons exhibit increased responsiveness associated with audiogenic seizures in the genetically epilepsy-prone rat

1998 • 68 citations

Reduction of gaba and glutamate transporter messenger rnas in the severe-seizure genetically epilepsy-prone rat

1998 • 67 citations

The role of the inferior colliculus in a genetic model of audiogenic seizures

1995 • 67 citations

Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response

1995 • 66 citations

Injections of noradrenergic and GABAergic agonists into the inferior colliculus: effects on audiogenic seizures in genetically epilepsy-prone rats

1989 • 66 citations

The Genetically Epilepsy-Prone Rat (GEPR)

1995 • 65 citations

Enhancement of the anticonvulsant effect of fluoxetine following blockade of 5-HT1A receptors

1997 • 62 citations

The effect of valproic acid on 5-hydroxytiyptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates In vivo

1991 • 62 citations

Blockade of GABA Uptake with Tiagabine Inhibits Audiogenic Seizures and Reduces Neuronal Firing in the Inferior Colliculus of the Genetically Epilepsy-Prone Rat

1994 • 60 citations

Angular bundle kindling is accelerated in rats with a genetic predisposition to acoustic stimulus-induced seizures

1986 • 58 citations

In situ hybridization for c-fos mRNA reveals the involvement of the superior colliculus in the propagation of seizure activity in genetically epilepsy-prone rats

1997 • 58 citations

Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study

1998 • 55 citations

Pontine reticular formation neurons exhibit a premature and precipitous increase in acoustic responses prior to audiogenic seizures in genetically epilepsy-prone rats

1995 • 53 citations

Effect of Precollicular Transection on Audiogenic Seizures in Genetically Epilepsy-Prone Rats

1999 • 51 citations

Anticonvulsant role of nigrotectal projection in the maximal electroshock model of epilepsy—II. Pathways from substantia nigra pars lateralis and adjacent peripeduncular area to the dorsal midbrain

1992 • 50 citations

Evaluation of the 5-hydroxytryptamine receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin in different rodent models of epilepsy

1985 • 49 citations

The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABAA, NMDA and opioid receptors

1999 • 48 citations

Amygdala Kindling of Forebrain Seizures and the Occurrence of Brainstem Seizures in Genetically Epilepsy‐Prone Rats

1996 • 47 citations

5‐Hydroxyindoleacetic Acid and Homovanillic Acid in Cerebrospinal Fluid of Children with Febrile Convulsions

1990 • 46 citations

Anatomy of epileptogenesis

1989 • 45 citations

Ictal epileptiform events induced by removal of extracellular magnesium in slices of entorhinal cortex are blocked by baclofen

1989 • 44 citations

Anticonvulsant properties of some calcium antagonists on sound-induced seizures in genetically epilepsy prone rats

1990 • 44 citations

The American Psychiatric Press Textbook of Psychopharmacology

1996 • 42 citations

Seizures and Proto-Oncogene Expression offosin the Brain of Adult Genetically Epilepsy-Prone Rats

1997 • 41 citations

Effects of zonisamide on K+ and Ca2+ evoked release of monoamine as well as K+ evoked intracellular Ca2+ mobilization in rat hippocampus

1999 • 39 citations

Sex-specific distinctions in audiogenic convulsions exhibited by severe seizure genetically epilepsy-prone rats (GEPR-9S) 1

1988 • 38 citations

Genetics of Focal Epilepsies

1999 • 38 citations

Differential Roles in the Neuronal Network for Audiogenic Seizures Are Observed among the Inferior Colliculus Subnuclei and the Amygdala

1999 • 37 citations

Audiogenic convulsions in moderate seizure genetically epilepsy-prone rats (GEPR-3s)

1989 • 36 citations

Effect of acute administration of various 5-HT receptor agonists on focal hippocampal seizures in freely moving rats

1998 • 36 citations

Modulation of the audiogenic seizure network by noradrenergic and glutamatergic receptors of the deep layers of superior colliculus

1999 • 35 citations

Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice

1999 • 33 citations

A microdialysis study of amino acid concentrations in the extracellular fluid of the substantia nigra of freely behaving GEPR-9s: relationship to seizure predisposition

1994 • 33 citations

Audiogenic kindling increases neuronal responses to acoustic stimuli in neurons of the medial geniculate body of the genetically epilepsy-prone rat

1997 • 31 citations

Responsiveness of genetically epilepsy-prone rats to aminophylline-induced seizures and interactions with quinolones

1991 • 28 citations

Neurotransmitter Systems and the Epilepsy Models

1987 • 26 citations

Effects of some AMPA receptor antagonists on the development of tolerance in epilepsy-prone rats and in pentylenetetrazole kindled rats

1999 • 25 citations

The dorsal midbrain anticonvulsant zone—II. Efferent connections revealed by the anterograde transport of wheatgerm agglutinin-horseradish peroxidase from injections centred on the intercollicular area in the rat

1995 • 25 citations

Morphological Deficits in Noradrenergic Neurons in GEPR-9s Stem from Abnormalities in both the Locus Coeruleus and Its Target Tissues

1999 • 23 citations

Mapping of Cerebral Blood Flow Changes during Audiogenic Seizures in Wistar Rats: Effect of Kindling

1995 • 22 citations

Effects of loreclezole on epileptic activity and on EEG and behaviour in rats with absence seizures

1992 • 22 citations

Changes in Simple and Complex Behaviors Following Kindled Seizures in Rats: Opioid and Nonopioid Mediation

1983 • 20 citations

Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus.

1996 • 19 citations

Blockade of GABAB receptors accelerates amygdala kindling development

1992 • 19 citations

Baclofen prevents rapid amygdala kindling in adult rats

1994 • 17 citations

A double-blind, placebo-controlled evaluation of the efficacy and safety of loreclezole as add-on therapy in patients with uncontrolled partial seizures

1991 • 17 citations

The anticonvulsant effect of the broad spectrum anticonvulsant loreclezole may be mediated in part by serotonin in rats: a microdialysis study

1994 • 17 citations

Blockade of the Tonic Hindlimb Extensor Component of Maximal Electroshock and Pentylenetetrazol‐Induced Seizures by Drugs Acting on Muscle and Muscle Spindle Systems: A Perspective on Method

1976 • 16 citations

Comprehensive Epileptology

1992 • 15 citations

The high pressure neurological syndrome in genetically epilepsy prone rats: Protective effect of 2-amino-7-phosphono heptanoate

1991 • 15 citations

Evidence of increased excitability in GEPR hippocampus preceding development of seizure susceptibility

1998 • 14 citations

Genetic and environmental models of stress-induced depression in rats

1998 • 14 citations

Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats

1996 • 11 citations

The Syndromes of Generalized Epilepsy

1990 • 9 citations

Protective effect of ucb L059 against postural stimulation-induced seizures in EL mice

1992 • 7 citations

Genetics of the Partial Epilepsies

1989 • 7 citations

Neurotransmitter Systems and the Epilepsy Models Distinguishing Features and Unifying Principles

2003 • 5 citations

Perspectives: Clues in Mapping Epilepsy Genes

1989 • 3 citations

Neural substrates correlated with the appearance of limbic seizures during repetitive acoustic stimulation of GEPR3

1998 • 3 citations

Alterations in brain and pituitary β-endorphin content in genetically epilepsy-prone rats

1998 • 2 citations

Interaction between Pefloxacin and Aminophylline in Genetically Epilepsy-prone Rats

1997 • 2 citations