The immunogenetics of rheumatoid arthritis

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Update on Key Emerging Challenges in Cystic Fibrosis

2014 • 3,606 citations

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

1989 • 3,458 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis

1978 • 1,170 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG

1985 • 1,136 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

HLA and Disease Associations

1985 • 893 citations

A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16

1985 • 715 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Assessing the role of HLA-linked and unlinked determinants of disease.

1987 • 548 citations

Isolation of CD4-CD8-mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid

1989 • 543 citations

OSTEOGENESIS IMPERFECTA IS LINKED TO BOTH TYPE I COLLAGEN STRUCTURAL GENES

1986 • 445 citations

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy

1989 • 394 citations

Molecular diversity of HLA-DR4 haplotypes.

1986 • 385 citations

HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

1989 • 376 citations

HLA Genes associated with rheumatoid Arthritis. Identification of susceptibility alleles using specific oligonucleotide probes

1989 • 345 citations

Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

1989 • 336 citations

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

1986 • 312 citations

SYNOVIAL FLUID T CELL REACTIVITY AGAINST 65 kD HEAT SHOCK PROTEIN OF MYCOBACTERIA IN EARLY CHRONIC ARTHRITIS

1988 • 311 citations

Occurrence of rheumatoid arthritis in a nationwide series of twins.

1986 • 308 citations

Three Recessive Loci Required for Insulin-Dependent Diabetes in Nonobese Diabetic Mice

1987 • 293 citations

Disease Associations with Complotypes, Supratypes and Haplotypes

1983 • 276 citations

Clonal dominance among T-lymphocyte infiltrates in arthritis.

1988 • 268 citations

Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.

1987 • 237 citations

Allelic variation in the DR subregion of the human major histocompatibility complex.

1987 • 220 citations

A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex

1989 • 219 citations

Heberden Oration, 1969. Rheumatoid arthritis--nature or nurture?

1970 • 189 citations

Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis

1986 • 184 citations

Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.

1989 • 183 citations

Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.

1982 • 168 citations

T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis.

1989 • 158 citations

IDENTIFICATION OF HLA-Dw14 GENES IN DR4+ RHEUMATOID ARTHRITIS

1986 • 150 citations

Increased Frequency of HLA‐Cw3 and HLA‐Dw4 in Rheumatoid Arthritis

1977 • 149 citations

Association between HLA and Japanese patients with rheumatoid arthritis

1982 • 138 citations

Association of HLA‐DR4/Dw4 and DR2/Dw2 with radiologic changes in a prospective study of patients with rheumatoid arthritis

1984 • 132 citations

Specific HLA-DR4-associated histocompatibility molecules characterize patients with seropositive juvenile rheumatoid arthritis.

1984 • 130 citations

DR antigens and rheumatoid arthritis: a study of two populations.

1981 • 128 citations

HLA and rheumatoid arthritis: a combined analysis of 440 British patients.

1986 • 110 citations

Measuring the genetic contribution of a single locus to a multilocus disease

1984 • 108 citations

Mixed Lymphocyte Culture Typing Cells from Patients with Rheumatoid Arthritis

1974 • 95 citations

Putative amino acid sequence of HLA-DRB chain contributing to rheumatoid arthritis susceptibility.

1989 • 95 citations

Nco I Restriction Fragment Length Polymorphism (RFLP) of the Tumor Necrosis Factor (TNFα) region in four autoimmune diseases

1989 • 89 citations

THE FAMILIAL AGGREGATION OF RHEUMATOID ARTHRITIS AND ITS RELATIONSHIP TO THE HLA-DR4 ASSOCIATION

1984 • 88 citations

Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease.

1983 • 84 citations

HLA-DQ BETA-CHAIN POLYMORPHISM IN HLA-DR4 HAPLOTYPES ASSOCIATED WITH RHEUMATOID ARTHRITIS

1987 • 77 citations

Serological and cellular definition of a new HLA-DR associated determinant, MC1, and its association with rheumatoid arthritis

1984 • 75 citations

Shared T cell recognition sites on human histocompatibility leukocyte antigen class II molecules of patients with seropositive rheumatoid arthritis.

1986 • 72 citations

HLA DR4 and rheumatoid arthritis in Japanese people.

1981 • 59 citations

HLA DQα and DQβ restriction fragment length polymorphisms associated with Felty's syndrome and DR4-positive rheumatoid arthritis

1987 • 56 citations

High-resolution linkage mapping for susceptibility genes in human polygenic disease: insulin-dependent diabetes mellitus and chromosome 11q.

1991 • 55 citations

The Molecular Basis of HLA—Disease Association

1989 • 55 citations

Dw subtypes of DR4 in rheumatoid arthritis: Evidence for a preferential association with Dw4

1986 • 53 citations

Immunogenetic heterogeneity of rheumatoid arthritis.

1986 • 53 citations

A locus telomeric toHLA-DPB encodes susceptibility to coeliac disease

1989 • 53 citations

A variant of HLA–DR4 determines susceptibility to rheumatoid arthritis in a subset of Israeli Jews

1991 • 49 citations

Genetics of rheumatoid arthritis

1986 • 47 citations

An analysis of variation in the long-range genomic organization of the human major histocompatibility complex class II region by pulsed-field gel electrophoresis

1989 • 47 citations

Hla antigens in yakima indians with rheumatoid arthritis. lack of association with hla–dw4 and hla–dr4

1982 • 45 citations

Genetic aspects of rheumatoid arthritis

1981 • 44 citations

Southern analysis of DNA polymorphism among Dw subtypes of DR4

1985 • 43 citations

Prevalence of Familial Occurrence in Patients with Rheumatoid Arthritis

1988 • 42 citations

Immunogenetics of rheumatoid arthritis in Israel

1986 • 41 citations

A dr4‐associated dr‐dq haplotype is significantly associated with rheumatoid arthritis

1988 • 37 citations

Strong association of rheumatoid arthritis with the presence of a polymorphic Ia epitope defined by a monoclonal antibody: comparison with the allodeterminant DR4

1984 • 36 citations

Simultaneous genetic mapping of multiple human minisatellite sequences using DNA fingerprinting

1989 • 32 citations

HLA and rheumatoid arthritis: an analysis of multicase families.

1986 • 32 citations

HL-A ANTIGENS IN RHEUMATOID ARTHRITIS

1974 • 31 citations

HLA‐DP in rheumatoid arthritis

1988 • 28 citations

A comparison of clinical and immunogenetic features in familial and sporadic rheumatoid arthritis.

1987 • 26 citations

HLA-DQ-RELATED RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN RHEUMATOID ARTHRITIS: EVIDENCE FOR A LINK WITH DISEASE EXPRESSION

1989 • 26 citations

Linkage studies of hla and rheumatoid arthritis in multicase families

1987 • 23 citations

Heterogeneity of HLA-DR4 in the rheumatoid arthritis of a Chippewa band.

1981 • 20 citations

Association of rheumatoid arthritis with HLA in three South African populations--whites, blacks and a population of mixed ancestry.

1989 • 19 citations

Chromosome 14 markers in rheumatoid arthritis.

1988 • 18 citations

A multicase family study of rheumatoid arthritis in south west Ireland.

1986 • 18 citations

Analysis of genetic interrelationship among HLA-associated diseases.

1987 • 17 citations

alpha 1 Antitrypsin (PI) allotypes in rheumatoid arthritis.

1986 • 17 citations

RHEUMATOLOGY EDUCATION IN THE LATE 20TH CENTURY

1989 • 14 citations

HLA-DR4 in Negro and Mexican rheumatoid arthritis patients.

1981 • 13 citations

HLA class III haplotypes in multicase rheumatoid arthritis families

1989 • 13 citations

HLA‐DR4 genotype frequency and gender effect in familial rheumatoid arthritis

1988 • 13 citations

Haplotypes bearing HLA‐A, ‐B, and ‐DR: Bf and C4 genes in rheumatoid arthritis families

1989 • 12 citations

T Cell receptor genes and disease susceptibility

1989 • 8 citations

Antigens of HLA-DR Locus in Rheumatoid Arthritis

1988 • 8 citations

HLA‐linked susceptibility to rheumatoid arthritis in North India

1988 • 5 citations

HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss Federal Commission for the Rheumatic Diseases, Subcommission for Research.

1986 • 5 citations