Function and regulation of hepatic and intestinal fatty acid binding proteins

A Binding Protein for Fatty Acids in Cytosol of Intestinal Mucosa, Liver, Myocardium, and Other Tissues

1972 • 713 citations

Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions

1969 • 589 citations

Fatty Acid-Binding Protein in Small Intestine IDENTIFICATION, ISOLATION, AND EVIDENCE FOR ITS ROLE IN CELLULAR FATTY ACID TRANSPORT

1974 • 458 citations

Effect of unsaturated acids on membrane structure and enzyme kinetics

1984 • 382 citations

Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein.

1984 • 287 citations

Fatty acid binding protein. Isolation from rat liver, characterization, and immunochemical quantification.

1982 • 286 citations

Delineation of the Dimensions and Permeability Characteristics of the Two Major Diffusion Barriers to Passive Mucosal Uptake in the Rabbit Intestine

1974 • 268 citations

A radiochemical procedure for the assay of fatty acid binding by proteins

1983 • 260 citations

The binding of fatty acids to cytoplasmic proteins: Binding to Z protein in liver and other tissues of the rat

1972 • 260 citations

Purification and properties of sterol carrier protein2.

1980 • 237 citations

The nucleotide sequence of rat liver fatty acid binding protein mRNA.

1983 • 235 citations

Review of the hepatic response to hypolipidaemic drugs in rodents and assessment of its toxicological significance to man

1981 • 233 citations

Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes.

1985 • 227 citations

Regulation of the biosynthesis of two distinct fatty acid-binding proteins in rat liver and intestine. Influences of sex difference and of clofibrate.

1985 • 213 citations

Mechanism and kinetics of transfer of a fluorescent fatty acid between single-walled phosphatidylcholine vesicles

1980 • 185 citations

Tissue specific expression and developmental regulation of two genes coding for rat fatty acid binding proteins.

1985 • 182 citations

Activation of fast skeletal muscle: contributions of studies on skinned fibers

1981 • 180 citations

Synthesis of very low density lipoproteins in the cockerel. Effects of estrogen.

1976 • 166 citations

The isolation of carcinogen-binding protein from livers of rats given 4-dimethylaminoazobenzene

1967 • 159 citations

A low-molecular-weight protein from rat liver that resembles ligandin in its binding properties

1976 • 158 citations

Intestinal metabolism of plasma free fatty acids. Intracellular compartmentation and mechanisms of control.

1975 • 140 citations

Diurnal variation of cytosolic fatty acid-binding protein content and of palmitate oxidation in rat liver and heart.

1984 • 131 citations

Fatty-Acid-Binding Proteins. Occurrence of Two Fatty-Acid-Binding Proteins in Bovine Liver Cytosol and Their Binding of Fatty Acids, Cholesterol, and Other Lipophilic Ligands

1984 • 130 citations

Sex Steroid Modulation of Fatty Acid Utilization and Fatty Acid Binding Protein Concentration in Rat Liver

1980 • 124 citations

Large scale purification and structural characterization of squalene and sterol carrier protein.

1981 • 122 citations

The influence of soluble binding proteins on lipophile transport and metabolism in hepatocytes

1981 • 121 citations

Fatty acid binding protein. Role in esterification of absorbed long chain fatty acid in rat intestine.

1976 • 121 citations

Sex Differences in Long Chain Fatty Acid Utilization and Fatty Acid Binding Protein Concentration in Rat Liver

1979 • 116 citations

Utilization of long chain fatty acids by rat liver: Studies of the role of fatty acid binding protein

1979 • 116 citations

Mechanism of oestrogen and progesterone effects on lipid and carbohydrate metabolism: alteration in the insulin: glucagon molar ratio and hepatic enzyme activity

1977 • 112 citations

Inhibition of rat liver acetyl coenzyme A carboxylase by long chain acyl coenzyme A and fatty acid. Modulation by fatty acid-binding protein.

1977 • 111 citations

Sterol carrier protein 2 and fatty acid-binding protein. Separate and distinct physiological functions.

1985 • 109 citations

Isolation and characterization of the three fractions (DE‐I, DE‐II and DE‐III) of rat‐liver Z‐protein and the complete primary structure of DE‐II

1983 • 107 citations

Fatty acid binding proteins from heart

1985 • 100 citations

The binding of long chain fatty acid CoA to Z, a cytoplasmic protein present in liver and other tissues of the rat

1974 • 94 citations

Purification and characterization of a long chain, fatty-acid-binding protein supplying the mitochondrial β-oxidative system in the heart

1978 • 94 citations

Fatty acid transfer between multilamellar liposomes and fatty acid-binding proteins.

1984 • 88 citations

Cytosolic modulators of activities of microsomal enzyme of cholesterol biosynthesis. Role of a cytosolic protein with properties similar to Z-protein (fatty acid-binding protein).

1980 • 88 citations

Possible involvement of fatty acid binding protein in peroxisomal β-oxidation of fatty acids

1980 • 84 citations

Modulation of membrane transport by free fatty acids: inhibition of synaptosomal sodium-dependent amino acid uptake

1983 • 84 citations

Increased uptake of fatty acids by the isolated rat liver after raising the fatty acid binding protein concentration with clofibrate

1978 • 84 citations

Stimulation of monoacylglycerophosphate formation

1974 • 82 citations

Stimulation of triacylglycerol synthesis by Z protein in rat liver and intestinal mucosa

1975 • 80 citations

Adaptive changes of the rat small intestine in response to a high fat diet

1972 • 79 citations

Z protein: Isolation and characterization of multiple forms in rat liver cytosol

1981 • 78 citations

The role of fatty acid binding protein on the metabolism of fatty acids in isolated rat hepatocytes

1976 • 75 citations

Z protein in hepatic uptake and esterification of long-chain fatty acids

1975 • 74 citations

Fatty acid binding protein from rat heart. The fatty acid binding proteins from rat heart and liver are different proteins.

1984 • 73 citations

Effects of peroxisome proliferators on fatty acid-binding protein in rat liver

1983 • 70 citations

Sex differences in hepatic uptake of long chain fatty acids in single-pass perfused rat liver

1981 • 69 citations

Effects of Free Fatty Acids on Synaptosomal Amino Acid Uptake Systems

1982 • 66 citations

Partial purification of molecular-weight-12,000 fatty acid-binding proteins from rat brain and their effect on synaptosomal sodium-dependent amino acid uptake

1984 • 65 citations

Stimulation of Biosynthesis of Glyceride

1967 • 62 citations

Cytosolic modulators of activities of microsomal enzymes of cholesterol biosynthesis effects of acyl-CoA inhibition and cytosolic Z-protein

1983 • 61 citations

Effect of hypolipidemic drugs, nafenopin and clofibrate, on the concentration of ligandin and Z protein in rat liver

1975 • 57 citations

Characterization and purification of fatty acid-binding protein in rat and human adipose tissue

1982 • 53 citations

Hepatic lipid metabolism: Effect of spermine, albumin, and Z protein on microsomal lipid formation

1979 • 53 citations

Regulation of Lipid Metabolism by a Lipid-Carrying Protein

1984 • 51 citations

Uptake of long-chain fatty acid methyl esters by mammalian cells

1970 • 49 citations

The interactions of haem with ligandin and aminoazo-dye-binding protein A.

1976 • 47 citations

Translational control of the circadian rhythm of liver sterol carrier protein.

1984 • 43 citations

Regulation of palmitoyl-CoA inhibition of mitochondrial adenine nucleotide transport by cytosolic fatty acid binding protein

1979 • 43 citations

Immunocytochemical localization of hepatic legandin and Z protein utilizing frozen sections for light and electron microscopy.

1979 • 37 citations

Studies on Z-Fraction. I. Isolation and Partial Characterization of Low Molecular Weight Ligand-Binding Protein from Rat Hepatic Cytosol

1975 • 34 citations

Does Z-Protein Have a Role in Transport of Bilirubin and Bromosulfophthalein by Isolated Perfused Rat Liver?

1984 • 33 citations

Circular dichroism analysis of the secondary structure of Z protein and its complexes with bilirubin and other organic anions

1975 • 33 citations

Ligandin and Z protein in binding of thyroid hormones by the liver

1976 • 31 citations

Effects of some hypolipidemic drugs and phthalic acid esters on fatty acid binding protein in rat liver.

1982 • 29 citations

Effect of dietary fat content on the site of fat absorption in hamster small intestine in vitro

1969 • 28 citations

A possible role of Z protein in dietary control of hepatic triacylglycerol synthesis.

1980 • 27 citations

Regulation of Fatty Acid and Glycerolipid Metabolism

1978 • 26 citations

A low molecular weight binding protein for organic anions (Z protein) from human hepatic cytosol: Purification and quantitation

1981 • 26 citations

Liver cytosolic fatty acid-binding proteins

1983 • 26 citations

Concomitant increase in hepatic triacylglycerol biosynthesis and cytosolic fatty-acid-binding-protein content after feeding rats with a cholestyramine-containing diet

1983 • 25 citations

Specific binding of saturated and unsaturated fatty acids on the ‘Z’‐protein of rat liver cytosol

1978 • 22 citations

Dietary induction of rat liver fatty acid binding protein

1983 • 22 citations

Conversion of diglyceride to triglyceride by rat liver microsomes: A requirement for the 105,000 × g supernatant

1974 • 20 citations

Oleic acid transfer from microsomes to egg lecithin liposomes: Participation of fatty acid binding protein

1983 • 20 citations

Reduced concentrations of Z protein in Morris hepatomas. Possible role in abnormal regulation of lipid metabolism.

1977 • 18 citations

A fatty acid binding peptide of rat liver cytosol

1979 • 17 citations

Role for fatty acid binding protein in the regulation of hepatic lipogenesis by dietary linoleic acid

1981 • 17 citations

Purification of liver cytosolic proteins that stimulate triacylglycerol synthesis

1981 • 13 citations

Possible relationship of the hepatic microsomal ATP-dependent calcium pump to sex differences in triacylglycerol synthesis

1978 • 13 citations

Effect of clofibrate on the metabolism of oleate in the perfused rat liver

1983 • 11 citations

Postnatal development and sex difference in hepatic phosphatidate phosphohydrolase activity in the rat

1981 • 11 citations

Loss of Regulation of Lipid Metabolism in Morris Hepatomas: A Potential Role for Cytoplasmic Binding Proteins

1978 • 10 citations