Simvastatin

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

The Lipid Research Clinics Coronary Primary Prevention Trial Results

1984 • 2,673 citations

Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study.

1986 • 2,283 citations

Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults

1988 • 2,276 citations

Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with High Levels of Apolipoprotein B

1990 • 2,192 citations

Can lifestyle changes reverse coronary heart disease?

1990 • 2,122 citations

Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease

1971 • 2,055 citations

Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin

1986 • 1,857 citations

Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)

1986 • 1,758 citations

Clofibrate and Niacin in Coronary Heart Disease

1975 • 1,660 citations

Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts

1987 • 1,651 citations

A Prospective Study of Cholesterol, Apolipoproteins, and the Risk of Myocardial Infarction

1991 • 1,184 citations

SERUM CHOLESTEROL, BLOOD PRESSURE, AND MORTALITY: IMPLICATIONS FROM A COHORT OF 361 662 MEN

1986 • 1,142 citations

A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators.

1978 • 1,058 citations

Effect of Partial Ileal Bypass Surgery on Mortality and Morbidity from Coronary Heart Disease in Patients with Hypercholesterolemia

1990 • 999 citations

Regression of Coronary Atherosclerosis During Treatment of Familial Hypercholesterolemia With Combined Drug Regimens

1990 • 793 citations

HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia

1988 • 760 citations

Reduction of Mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by Combined Treatment with Clofibrate and Nicotinic Acid

1988 • 693 citations

Effects of therapy with cholestyramine on progression of coronary arteriosclerosis: results of the NHLBI Type II Coronary Intervention Study.

1984 • 685 citations

The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering

1984 • 631 citations

The Decline in Ischemic Heart Disease Mortality Rates

1984 • 561 citations

Lipoproteins and Atherogenesis

1990 • 549 citations

Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Panel

1988 • 536 citations

Diet, Lipoproteins, and the Progression of Coronary Atherosclerosis

1985 • 494 citations

Beneficial Effects of Colestipol-Niacin on Coronary Atherosclerosis

1990 • 492 citations

Changes in Risk Factors and the Decline in Mortality from Cardiovascular Disease

1990 • 482 citations

CONTROLLED TRIAL OF SOYA-BEAN OIL IN MYOCARDIAL INFARCTION

1968 • 473 citations

The Oslo Diet-Heart Study

1970 • 456 citations

Low-fat diet in myocardial infarction: A controlled trial.

1965 • 437 citations

The pathogenesis of atherosclerosis: An overview

1991 • 306 citations

The Coronary Drug Project

1972 • 306 citations

Cost-Effectiveness of Interventions to Prevent or Treat Coronary Heart Disease

1985 • 226 citations

Simvastatin

1990 • 219 citations

Trial of Clofibrate in the Treatment of Ischaemic Heart Disease: FIVE-YEAR STUDY BY A GROUP OF PHYSICIANS OF THE NEWCASTLE UPON TYNE REGION

1971 • 210 citations

Cost-effectiveness of Antihyperlipemic Therapy in the Prevention of Coronary Heart Disease

1987 • 176 citations

Long-term mortality after 5-year multifactorial primary prevention of cardiovascular diseases in middle-aged men.

1991 • 175 citations

Cutting into cholesterol. Cost-effective alternatives for treating hypercholesterolemia

1988 • 160 citations

Therapeutic Response to Lovastatin (Mevinolin) in Nonfamilial Hypercholesterolemia

1986 • 160 citations

Diet, Lipoproteins and the Progression of Coronary Atherosclerosis

1986 • 148 citations

Reducing High Blood Cholesterol Level With Drugs

1990 • 124 citations

Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up

1990 • 119 citations

Pravastatin

1991 • 117 citations

Cutting Into Cholesterol

1988 • 114 citations

Long-term safety and efficacy profile of simvastatin

1991 • 113 citations

Simvastatin: The clinical profile

1989 • 80 citations

Primary prevention and coronary heart disease: the economic benefits of lowering serum cholesterol.

1986 • 80 citations

Cost effectiveness of incremental programmes for lowering serum cholesterol concentration: is individual intervention worth while?

1991 • 77 citations

An economic evaluation of lovastatin for cholesterol lowering and coronary artery disease reduction

1991 • 73 citations

Cholesterol, Children, and Heart Disease: An Analysis of Alternatives

1981 • 70 citations

Effects of Simvastatin and Cholestyramine in Familial and Nonfamilial Hypercholesterolemia

1990 • 64 citations

The coronary drug project. Findings leading to further modifications of its protocol with respect to dextrothyroxine. The coronary drug project research group

1972 • 63 citations

Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits.

1989 • 58 citations

Cost effectiveness of cholesterol-lowering therapy in The Netherlands

1989 • 55 citations

Clinical benefits and cost-effectiveness of lowering serum cholesterol levels: The case of simvastatin and cholestyramine in The Netherlands

1990 • 53 citations

Effects of simvastatin and probucol in hypercholesterolemia (simvastatin multicenter study group II)

1989 • 50 citations

Comparison of low-dose simvastatin and gemfibrozil in the treatment of elevated plasma cholesterol

1989 • 48 citations

Simvastatin: A Review of its Pharmacology and Clinical Use

1991 • 46 citations

Comparison of different HMG-CoA reductase inhibitors

1991 • 37 citations

Comparative effects of simvastatin and cholestyramine in treatment of patients with hypercholesterolaemia

1989 • 36 citations

Current pharmacologic treatment of elevated serum cholesterol.

1987 • 36 citations

Simvastatin versus pravastatin: efficacy and tolerability in patients with primary hypercholesterolemia.

1991 • 34 citations

Clinical Implications of New Drugs for Lowering Plasma Cholesterol Concentrations

1991 • 34 citations

Safety, Tolerability, and Efficacy of Simvastatin and Fenofibrate - A Multicenter Study

1990 • 32 citations

Ischaemic heart disease: a secondary prevention trial using clofibrate. Report by a research committee of the Scottish Society of Physicians.

1971 • 31 citations

Medication compliance and serum lipid changes in the Helsinki Heart Study.

1991 • 29 citations

Long-Term Clinical Tolerance of Lovastatin and Simvastatin

1990 • 26 citations

The benefits of reducing cholesterol levels: the need to distinguish primary from secondary prevention: 1. A meta‐analysis of cholesterol‐lowering trials

1991 • 26 citations

Overview of clinical trials of cholesterol lowering in relationship to epidemiologie studies

1989 • 25 citations

Clinical Experience with Simvastatin Compared with Cholestyramine

1988 • 24 citations

Lovastatin and simvastatin prevention studies

1990 • 23 citations

Costs and benefits of risk factor reduction for coronary heart disease: Insights from screening and treatment of serum cholesterol

1990 • 23 citations

The epidemiology of hypercholesterolemia

1989 • 22 citations

Screening for hypercholesterolemia among Canadians: how much will it cost?

1991 • 20 citations

SIMVASTATIN (MK 733): AN EFFECTIVE TREATMENT FOR HYPERCHOLESTEROLEMIA

1989 • 20 citations

Epidemiology of Hypercholesterolemia and European Management Guidelines

1990 • 20 citations

Comparison of simvastatin and cholestyramine in the treatment of primary hypercholesterolemia

1990 • 18 citations

Cholesterol and coronary artery disease what do clinicians do now?

1986 • 17 citations

The Lipoprotein Receptor Concept

1988 • 17 citations

Simvastatin and cholestyramine in the long-term treatment of hypercholesterolaemia

1989 • 16 citations

Effects of simvastatin and fenofibrate on serum lipoproteins and apolipoproteins in primary hypercholesterolaemia

1989 • 16 citations

Combination Drug Therapy with HMG CoA Reductase Inhibitors and Bile Acid Sequestrants for Hypercholesterolemia

1990 • 14 citations

The Role of Plasma Lipids as Predictors of Risk for Coronary Heart Disease1

1990 • 14 citations

Managing Elevated Blood Lipid Concentrations

1990 • 13 citations

Management of hypercholesterolemia

1989 • 13 citations

12 The economics of cholesterol lowering

1990 • 12 citations

Effects of long-term treatment with simvastatin on plasma lipids and lipoproteins in patients with primary hypercholesterolemia

1990 • 12 citations

Cholesterol and coronary artery disease.

1949 • 11 citations

Comparison between low-dose simvastatin and cholestyramine in moderately severe hypercholesterolemia.

1989 • 9 citations

Hypercholesterolemia: the cost of treatment in perspective.

1990 • 7 citations

Effects of HMG CoA Reductase Inhibitors on Warfarin Binding

1991 • 7 citations

[The efficacy and tolerance of simvastatin and fenofibrate in primary hypercholesterolemia].

1990 • 6 citations

Lipoprotein Metabolism and Atherogenesis: Implications for Therapy

1991 • 5 citations

Normal and Pathological Lipoprotein Metabolism

1988 • 5 citations

Bezafibrate and simvastatin (MK-733) in the treatment of primary hypercholesterolaemia.

1990 • 5 citations

Drugs affecting lipid metabolism

1988 • 5 citations

[Evaluation of tolerance, efficacy and safety of 3-year simvastatin use in the treatment of primary hypercholesterolemia].

1990 • 4 citations

[Simvastatin versus gemfibrozil in the treatment of primary hypercholesterolemia in hypertensive patients treated with hydrochlorothiazide].

1990 • 3 citations

Bezafibrate and simvastatin (MK-733) in the treatment of primary hypercholesterolaemia.

1990 • 3 citations

EFFICACY OF SIMVASTATIN PLUS CHOLESTYRAMINE IN THE TWO-YEAR TREATMENT OF HETEROZYGOUS HYPERCHOLESTEROLEMIA

1990 • 3 citations

Hypercholesterolaemia in Aged Patients

1991 • 3 citations

[Cost-effectiveness of lowering of blood cholesterol using simvastatin and cholestyramine].

1991 • 3 citations

Interaction of Lipoproteins with the Artery Wall

1988 • 2 citations

National Cholesterol Education Program. Scientific rationale.

1989 • 1 citations

[Comparison of the lowering effect on blood cholesterol of clofibrate and simvastatin].

1990 • 1 citations

[HMG-CoA reductase inhibitors in familial hypercholesterolemia. Therapy with simvastatin alone and in combination with cholestyramine in low dosage; a report of 2 years experiences].

1990 • 1 citations

Deleted Work

1955 • 0 citations