The interaction of 4-DAMP mustard with subtypes of the muscarinic receptor

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Pirenzepine distinguishes between different subclasses of muscarinic receptors

1980 • 1,299 citations

Psychopharmacology: The Fourth Generation of Progress

1996 • 755 citations

A COMPARISON OF AFFINITY CONSTANTS FOR MUSCARINE‐SENSITIVE ACETYLCHOLINE RECEPTORS IN GUINEA‐PIG ATRIAL PACEMAKER CELLS AT 29°C AND IN ILEUM AT 29°C AND 37°C

1976 • 292 citations

Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist

1986 • 283 citations

M2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine airway smooth muscle.

1992 • 117 citations

Differential coupling of subtypes of the muscarinic receptor to adenylate cyclase and phosphoinositide hydrolysis in the longitudinal muscle of the rat ileum.

1990 • 113 citations

An alkylating derivative of benzilylcholine with specific and long-lasting parasympatholytic activity.

1966 • 112 citations

Muscarinic receptor subtypes coupled to generation of different second messengers in isolated tracheal smooth muscle cells

1991 • 105 citations

Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum.

1993 • 102 citations

Muscarinic receptors in canine colonic circular smooth muscle. I. Coexistence of M2 and M3 subtypes.

1991 • 99 citations

Binding and functional characterization of the cardioselective muscarinic antagonist methoctramine.

1988 • 94 citations

Methoctramine reveals heterogeneity of M2 muscarinic receptors in longitudinal ileal smooth muscle membranes

1988 • 86 citations

Muscarinic receptors: relationships among phosphoinositide breakdown, adenylate cyclase inhibition, in vitro detrusor muscle contractions and in vivo cystometrogram studies in guinea pig bladder.

1989 • 72 citations

Muscarinic receptor heterogeneity in guinea pig intestinal smooth muscle: binding studies with AF-DX 116

1987 • 72 citations

Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways.

1991 • 65 citations

Characterization of the interaction between muscarinic M₂ receptors and β‐adrenoceptor subtypes in guinea‐pig isolated ileum

1995 • 60 citations

Effects of muscarinic M₂ and M₃ receptor stimulation and antagonism on responses to isoprenaline of guinea‐pig trachea in vitro

1994 • 49 citations

Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis.

1994 • 49 citations

Cloning of the rat m3, m4 and m5 muscarinic acetylcholine receptor genes by the Polymerase Chain Reaction (PCR) and the pharmacological characterization of the expressed genes

1992 • 47 citations

Specific inhibition of isoproterenol-stimulated cyclic AMP accumulation by M2 muscarinic receptors in rat intestinal smooth muscle.

1992 • 45 citations

Comparison of the muscarinic receptors of the guinea‐pig oesophageal muscularis mucosae and trachea in vitro

1988 • 45 citations

Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues.

1992 • 44 citations

Functional role of M2 muscarinic receptors in the guinea pig ileum

1995 • 42 citations

Selective and enantiospecific acylation of .kappa.-opioid receptors by (1S,2S)-trans-2-isothiocyanato-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide. Demonstration of .kappa. receptor heterogeneity

1989 • 40 citations

No evidence for a role of muscarinic M₂ receptors in functional antagonism in bovine trachea

1995 • 32 citations

Muscarinic M2 receptors do not participate in the functional antagonism between methacholine and isoprenaline in guinea pig tracheal smooth muscle

1993 • 30 citations

Coupling of muscarinic receptors to adenylate cyclase in the rabbit myocardium: effects of receptor inactivation.

1987 • 26 citations

Characterization of muscarinic receptors in dog tracheal smooth muscle cells

1991 • 25 citations

Tertiary (2-haloethyl)amine derivatives of the muscarinic agent McN-A-343, [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride

1990 • 23 citations

Role of muscarinic M2 and M3 receptors in guinea-pig trachea: effects of receptor alkylation

1995 • 21 citations

The binding of a 2-chloroethylamine derivative of oxotremorine (BM 123) to muscarinic receptors in the rat cerebral cortex.

1985 • 20 citations

THE IRREVERSIBLE BINDING OF ACETYLCHOLINE MUSTARD TO MUSCARINIC RECEPTORS IN INTESTINAL SMOOTH MUSCLE OF THE GUINEA‐PIG

1975 • 20 citations

The conversion of 2-chloroalkylamine analogues of oxotremorine to aziridinium ions and their interactions with muscarinic receptors in the guinea pig ileum.

1984 • 20 citations

Some Differential Effects of 4-Diphenylacetoxy-N-(2-chloroethyl)-piperidine Hydrochloride on Guinea-pig Atria and Ileum

1990 • 14 citations

Irreversible binding of acetylethylcholine mustard to cardiac cholinergic muscarinic receptors.

1986 • 8 citations

Blockade of muscarinic receptors by alkylating agonist analogues

1990 • 5 citations