Insulin analogues and their potential in the management of diabetes mellitus

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

The Effect of Long-Term Intensified Insulin Treatment on the Development of Microvascular Complications of Diabetes Mellitus

1993 • 1,215 citations

Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by

1972 • 831 citations

Monomeric insulins obtained by protein engineering and their medical implications

1988 • 493 citations

[Lys(B28), Pro(B29)]-Human Insulin: A Rapidly Absorbed Analogue of Human Insulin

1994 • 453 citations

Monomeric Insulins and Their Experimental and Clinical Implications

1990 • 374 citations

Insulin Pharmacokinetics

1984 • 336 citations

Reduction of Postprandial Hyperglycemia and Frequency of Hypoglycemia in IDDM Patients on Insulin-Analog Treatment

1997 • 325 citations

Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo

1995 • 313 citations

Decreased Epinephrine Responses to Hypoglycemia during Sleep

1998 • 294 citations

Absorption of Injected Insulin

1969 • 288 citations

Control of Blood Sugar in Insulin-Dependent Diabetes: Comparison of an Artificial Endocrine Pancreas, Continuous Subcutaneous Insulin Infusion, and Intensified Conventional Insulin Therapy

1980 • 279 citations

Role of zinc in insulin biosynthesis

1980 • 251 citations

Metabolic and immunologic effects of insulin lispro in gestational diabetes.

1999 • 237 citations

Insulin Lispro in CSII: Results of a Double-Blind Crossover Study

1997 • 232 citations

Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs

1996 • 225 citations

Meta-Analysis of the Effect of Insulin Lispro on Severe Hypoglycemia in Patients With Type 1 Diabetes

1998 • 222 citations

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term complications in Insulin-Dependent Diabetes Mellitus

1994 • 219 citations

Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM

1994 • 209 citations

Induction of Hypoglycemia Unawareness by Asymptomatic Nocturnal Hypoglycemia

1993 • 202 citations

Long-term intensive treatment of type 1 diabetes with the short-acting insulin analog lispro in variable combination with NPH insulin at mealtime.

1999 • 199 citations

Altering the association properties of insulin by amino acid replacement

1992 • 198 citations

Insulin analogs with improved pharmacokinetic profiles

1999 • 192 citations

Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

1996 • 187 citations

Intensified insulin therapy and the risk of severe hypoglycaemia

1997 • 184 citations

The emerging role of post-prandial hyperglycaemic spikes in the pathogenesis of diabetic complications

1998 • 179 citations

Mealtime treatment with insulin analog improves postprandial hyperglycemia and hypoglycemia in patients with non-insulin-dependent diabetes mellitus. Multicenter Insulin Lispro Study Group

1997 • 177 citations

Improved postprandial glycemic control with insulin aspart. A randomized double-blind cross-over trial in type 1 diabetes.

1999 • 176 citations

Use of insulin lispro in continuous subcutaneous insulin infusion treatment. Results of a multicenter trial. German Humalog-CSII Study Group.

1999 • 171 citations

Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients.

1999 • 171 citations

Time‐action profile of the soluble, fatty acid acylated, long‐acting insulin analogue NN304

1999 • 161 citations

Variability of the metabolic effect of soluble insulin and the rapid-acting insulin analog insulin aspart.

1998 • 161 citations

Importance of Timing of Preprandial Subcutaneous Insulin Administration in the Management of Diabetes Mellitus

1983 • 154 citations

Injection Site Effects on the Pharmacokinetics and Glucodynamics of Insulin Lispro and Regular Insulin

1996 • 147 citations

The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake

1992 • 144 citations

Improvement of HbA1c and Blood Glucose Stability in IDDM Patients Treated With Lispro Insulin Analog in External Pumps

1998 • 143 citations

Modifications in the B10 and B26-30 regions of the B chain of human insulin alter affinity for the human IGF-I receptor more than for the insulin receptor

1997 • 142 citations

Comparative pharmacokinetics and pharmacodynamics of the novel rapid-acting insulin analogue, insulin aspart, in healthy volunteers

1999 • 137 citations

Reduced Frequency of Severe Hypoglycemia and Coma in Well-Controlled IDDM Patients Treated With Insulin Lispro

1997 • 136 citations

Biosynthetic Human Proinsulin: Review of Chemistry, in Vitro and in Vivo Receptor Binding, Animal and Human Pharmacology Studies, and Clinical Trial Experience

1992 • 132 citations

Mealtime Treatment With Insulin Analog Improves Postprandial Hyperglycemia and Hypoglycemia in Patients With Non-Insulin-Dependent Diabetes Mellitus

1997 • 130 citations

Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM

1994 • 129 citations

Subcutaneous Insulin Absorption Explained by Insulin's Physicochemical Properties: Evidence From Absorption Studies of Soluble Human Insulin and Insulin Analogues in Humans

1991 • 126 citations

Insulin Aspart in a 30/70 Premixed Formulation: Pharmacodynamic properties of a rapid-acting insulin analog in stable mixture

1997 • 125 citations

Health-Related Quality-of-Life Results From Multinational Clinical Trials of Insulin Lispro: Assessing benefits of a new diabetes therapy

1997 • 125 citations

Prandial Glycaemia After a Carbohydrate-rich Meal in Type I Diabetic Patients: Using the Rapid Acting Insulin Analogue [Lys(B28), Pro(B29)] Human Insulin

1996 • 123 citations

[Lys(B28), Pro(B29)]-human insulin. A rapidly absorbed analogue of human insulin

1994 • 122 citations

Improved mealtime treatment of diabetes mellitus using an insulin analogue

1997 • 120 citations

Effect of Fatty Acids and Selected Drugs on the Albumin Binding of a Long-Acting, Acylated Insulin Analogue

1997 • 119 citations

Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes.

1998 • 117 citations

Risk factors of severe hypoglycaemia in adult patients with Type I diabetes - a prospective population based study

1998 • 117 citations

Exercise-induced hypoglycaemia in IDDM patients treated with a short-acting insulin analogue

1995 • 112 citations

Improved postprandial glycemic control during treatment with Humalog Mix25, a novel protamine-based insulin lispro formulation. Humalog Mix25 Study Group.

1999 • 112 citations

Growth promoting and metabolic activity of the human insulin analogue [GlyA21,ArgB31,ArgB32]insulin (HOE 901) in muscle cells

1997 • 110 citations

Time-Action Profiles of Novel Premixed Preparations of Insulin Lispro and NPL Insulin

1998 • 109 citations

Nocturnal hypoglycaemia in patients receiving conventional treatment with insulin.

1985 • 109 citations

The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model

1994 • 106 citations

Contribution of postprandial versus interprandial blood glucose to HbA1c in type 1 diabetes on physiologic intensive therapy with lispro insulin at mealtime.

1999 • 101 citations

Comparison of Human Regular and Lispro Insulins After Interruption of Continuous Subcutaneous Insulin Infusion and in the Treatment of Acutely Decompensated IDDM

1998 • 99 citations

Insulin lispro in CSII: results of a double-blind crossover study

1997 • 99 citations

Use of the short-acting insulin analogue lispro in intensive treatment of Type 1 diabetes mellitus: importance of appropriate replacement of basal insulin and time-interval injection-meal

1998 • 98 citations

Severe Antibody-Mediated Human Insulin Resistance: Successful Treatment With the Insulin Analog Lispro: A case report

1997 • 96 citations

Factors influencing the magnitude, duration, and rate of fall of B-cell function in Type 1 (insulin-dependent) diabetic children followed for two years from their clinical diagnosis

1988 • 95 citations

The Long Acting Human Insulin Analog HOE 901: Characteristics of Insulin Signalling in Comparison to Asp(B10) and Regular Insulin

1998 • 95 citations

Receptor Binding and Tyrosine Kinase Activation by Insulin Analogues With Extreme Affinities Studied in Human Hepatoma HepG2 Cells

1991 • 94 citations

Effectiveness of Postprandial Humalog in Toddlers With Diabetes

1997 • 93 citations

Intensive insulin therapy with insulin lispro in patients with type 1 diabetes reduces the frequency of hypoglycemic episodes

2009 • 91 citations

Comparison of Subcutaneous Soluble Human Insulin and Insulin Analogues (AspB9, GluB27; AspB10; AspB28) on Meal-Related Plasma Glucose Excursions in Type I Diabetic Subjects

1991 • 90 citations

Nocturnal spikes of growth hormone secretion cause the dawn phenomenon in Type 1 (insulin-dependent) diabetes mellitus by decreasing hepatic (and extrahepatic) sensitivity to insulin in the absence of insulin waning

1990 • 89 citations

Action Profile of the Rapid Acting Insulin Analogue: Human Insulin B28Asp

1993 • 87 citations

The dawn phenomenon in Type 1 (insulin-dependent) diabetes mellitus: magnitude, frequency, variability, and dependency on glucose counterregulation and insulin sensitivity

1991 • 84 citations

Strategies Toward Improved Control During Insulin Lispro Therapy in IDDM: Importance of basal insulin

1997 • 79 citations

Pathogenesis and Prevention of the Dawn Phenomenon in Diabetic Patients Treated with CSII

1986 • 78 citations

Modification of Postprandial Hyperglycemia With Insulin Lispro Improves Glucose Control in Patients With Type 2 Diabetes

1997 • 77 citations

Effects of the Short-Acting Insulin Analog [Lys(B28),Pro(B29)] on Postprandial Blood Glucose Control in IDDM

1996 • 77 citations

Preparation of an Insulin with Improved Pharmacokinetics Relative to Human Insulin through Consideration of Structural Homology with Insulin-Like Growth Factor I

1994 • 76 citations

Metabolic Efficacy of Preprandial Administration of Lys(B28), Pro(B29) Human Insulin Analog in IDDM Patients: A comparison with human regular insulin during a three-meal test period

1997 • 76 citations

Postprandial Insulin Lispro: A new therapeutic option for type 1 diabetic patients

1998 • 76 citations

Immunologic Effects of Insulin Lispro [Lys (B28), Pro (B29) Human Insulin] in IDDM and NIDDM Patients Previously Treated With Insulin

1996 • 75 citations

In Vitro and In Vivo Potency of Insulin Analogues Designed for Clinical Use

1991 • 74 citations

Lispro Mix25 insulin as premeal therapy in type 2 diabetic patients.

1999 • 72 citations

Glycemic control in patients with diabetes in Finland.

1999 • 70 citations

Meal Composition is a Determinant of Lispro-Induced Hypoglycemia in IDDM

1997 • 69 citations

The physiological basis of insulin treatment ? clinical aspects

1986 • 66 citations

Substitution of night-time continuous subcutaneous insulin infusion therapy for bedtime NPH insulin in a multiple injection regimen improves counterregulatory hormonal responses and warning symptoms of hypoglycaemia in IDDM

1998 • 65 citations

The Effect of the Insulin Analog Lispro on Nighttime Blood Glucose Control in Type 1 Diabetic Patients

1998 • 62 citations

The Absorption of Subcutaneously Injected Short-Acting Soluble Insulin: Influence of Injection Technique and Concentration

1983 • 61 citations

Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia

1996 • 59 citations

NovoSol Basal: pharmacokinetics of a novel soluble long acting insulin analogue.

1989 • 59 citations

Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia

1993 • 58 citations

Lispro Analog for Treatment of Generalized Allergy to Human Insulin

1997 • 58 citations

Comparison of Metabolic Deterioration between Insulin Analog and Regular Insulin after a 5-Hour Interruption of a Continuous Subcutaneous Insulin Infusion in Type 1 Diabetic Patients1

1999 • 58 citations

Acylation of Human Insulin With Palmitic Acid Extends the Time Action of Human Insulin in Diabetic Dogs

1997 • 56 citations

Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells

1998 • 50 citations

Soluble, prolonged-acting insulin derivatives. I. Degree of protraction and crystallizability of insulins substituted in the termini of the B-chain

1987 • 50 citations

Improvement of blood glucose control in Type 1 diabetic patients treated with lispro and multiple NPH injections

1999 • 46 citations

Long-term comparison of human insulin analogue B10Asp and soluble human insulin in IDDM patients on a basal/bolus insulin regimen

1995 • 40 citations

The Effect of Long-term Intensified Insulin Treatment on the Development of Microvascular Complications of Diabetes Mellitus

1994 • 35 citations

The Effect of Asymptomatic Nocturnal Hypoglycemia on Glycemic Control in Diabetes Mellitus

1988 • 34 citations

Insulin glargine: the first clinically useful extended-acting insulin in half a century?

1999 • 33 citations

Comparison of LysB28, ProB29-Human Insulin Analog and Regular Human Insulin in the Correction of Incidental Hyperglycemia

1996 • 32 citations

Effectiveness of human ultralente versus NPH insulin in providing basal insulin replacement for an insulin lispro multiple daily injection regimen. A double-blind randomized prospective trial. The Canadian Lispro Study Group.

1999 • 31 citations

Nighttime Insulin Kinetics and Glycemic Control in Type 1 Diabetes Patients Following Administration of an Intermediate-Acting Lispro Preparation

1997 • 29 citations

Optimal Provision of Daytime NPH Insulin in Patients Using the Insulin Analog Lispro

1998 • 27 citations

Symptomatic and physiological responses to hypoglycaemia induced by human soluble insulin and the analogue Lispro human insulin

1997 • 25 citations

A Reproductive and Developmental Toxicity Study in CD Rats of LY275585, [Lys(B28),Pro(B29)]-Human Insulin

1994 • 25 citations

Long‐term efficacy of Humalogã in subjects with Type 1 diabetes mellitus

1999 • 24 citations

The Action Profile of Lispro Is Not Blunted by Mixing in the Syringe With NPH Insulin

1998 • 24 citations

Acylation of human insulin with palmitic acid extends the time action of human insulin in diabetic dogs

1997 • 22 citations

Basal activity profiles of NPH and [N ε -palmitoyl Lys (B29)] human insulins in subjects with IDDM

1998 • 22 citations

Reducing snacks when switching from conventional soluble to lispro insulin treatment: effects on glycaemic control and hypoglycaemia

1998 • 20 citations

Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs

1996 • 20 citations

Receptor binding and tyrosine kinase activation by insulin analogues with extreme affinities studied in human hepatoma HepG2 cells

1991 • 19 citations

Optimization of Evening Insulin Dose in Patients Using the Short-Acting Insulin Analog Lispro

1998 • 18 citations

Immunogenicity of biosynthetic human LysPro insulin compared to native-sequence human and purified porcine insulins in rhesus monkeys immunized over a 6-week period.

1995 • 18 citations

Bioavailability and Bioeffectiveness of Subcutaneous Human Insulin and Two of its Analogs—LysB28ProB29-Human Insulin and AspB10LysB28ProB29-Human Insulin—Assessed in a Conscious Pig Model

1997 • 17 citations

Apoptotic Effects of Hexadecylphosphocholine on Resistent and Non-Resistant Cells Monitored by NMR Spectroscopy

1998 • 15 citations

12-Month Chronic Toxicity Study of LY275585 (Human Insulin Analog) Administered Subcutaneously to Fischer 344 Rats

1997 • 12 citations

Effect of Continuous Subcutaneous Insulin Infusion With Lispro on Hepatic Responsiveness to Glucagon in Type 1 Diabetes

1998 • 10 citations

Postprandial Hyperglycaemia Following a Morning Hypoglycaemia in Type 1 Diabetes Mellitus

1990 • 10 citations

Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM

1994 • 8 citations

Bioavailability and bioeffectiveness of subcutaneous human insulin and two of its analogs--LysB28ProB29-human insulin and AspB10LysB28ProB29-human insulin--assessed in a conscious pig model

1997 • 6 citations

Time-action profiles of the intermediate-acting insulin analogue des(64,65)-human proinsulin.

1995 • 5 citations

Successful Treatment With Insulin Analog Lispro in IDDM With Delayed Absorption of Subcutaneously Applied Human Regular Insulin and Complicated Intraperitoneal Insulin Infusion: A case report

1998 • 4 citations

Effects of surface hydrophobicity on the structural properties of insulin

1997 • 3 citations

Decreased Epinephrine Response to Hypoglycemia During Sleep.

1998 • 3 citations

Long-term intensive insulin therapy in IDDM: effects on HbA1 c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia

1996 • 2 citations

Deleted Work

1955 • 0 citations