The major transcriptional regulatory protein of herpes simplex virus type 1 includes a protease resistant DNA binding domain

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1

1988 • 1,618 citations

Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild-type virus or the temperature-sensitive mutant tsK

1979 • 496 citations

Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175

1980 • 436 citations

Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4

1981 • 436 citations

Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity.

1984 • 396 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1

1986 • 335 citations

Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation

1985 • 285 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Activation of Immediate-Early, Early, and Late Promoters by Temperature-Sensitive and Wild-Type Forms of Herpes Simplex Virus Type 1 Protein ICP4

1985 • 273 citations

Regulation of herpesvirus macromolecular synthesis V. Properties of α polypeptides made in HSV-1 and HSV-2 infected cells

1977 • 253 citations

Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4

1988 • 225 citations

Control of Protein Synthesis in Herpesvirus-infected Cells: Analysis of the Polypeptides Induced by Wild Type and Sixteen Temperature-sensitive Mutants of HSV strain 17

1976 • 211 citations

Enhancing the efficiency of DNA-mediated gene transfer in mammalian cells

1981 • 208 citations

Characterization of the IE110 Gene of Herpes Simplex Virus Type 1

1986 • 192 citations

Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides

1987 • 183 citations

Association of the herpes simplex virus regulatory protein ICP4 with specific nucleotide sequences in DNA

1986 • 165 citations

Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site

1987 • 158 citations

Direct correlation between a negative autoregulatory response element at the cap site of the herpes simplex virus type 1 IE175 (alpha 4) promoter and a specific binding site for the IE175 (ICP4) protein

1988 • 149 citations

The DNA-Binding Properties of the Major Regulatory Protein α4 of Herpes Simplex Viruses

1988 • 144 citations

Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression

1984 • 122 citations

Isolation and characterization of a large molecular-weight polypeptide of herpes simplex virus type 1

1974 • 119 citations

A detailed analysis of an HSV-1 early promoter: sequences involved in trans-activation by viral immediate-early gene products are not early-gene specific

1984 • 117 citations

Separation of primary structural components conferring autoregulation, transactivation, and DNA-binding properties to the herpes simplex virus transcriptional regulatory protein ICP4

1989 • 108 citations

The regulation of transcription of viral and cellular genes by herpesvirus immediate-early gene products (review).

1987 • 102 citations

DNA sequence and comparative analyses of the equine herpesvirus type 1 immediate early gene

1989 • 100 citations

Mutational dissection of the HSV-1 immediate-early protein Vmw175 involved in transcriptional transactivation and repression

1988 • 88 citations

The regions of the herpes simplex virus type 1 immediate early protein Vmwl75 required for site specific DNA binding closely correspond to those involved in transcriptional regulation

1988 • 87 citations

Herpes simplex virus immediate early infected-cell polypeptide 4 binds to DNA and promotes transcription.

1986 • 82 citations

DNA sequence elements required for regulated expression of the HSV-1 glycoprotein D gene lie within 83 bp of the RNA capsites

1983 • 82 citations

Fine-structure mapping of herpes simplex virus type 1 temperature-sensitive mutations within the short repeat region of the genome

1981 • 79 citations

Determination of the Sequence Alteration in the DNA of the Herpes Simplex Virus Type 1 Temperature-sensitive Mutant ts K

1984 • 75 citations

Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4

1989 • 49 citations

ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4

1989 • 49 citations

Poly(ADP-ribosyl)ation of a herpes simplex virus immediate early polypeptide

1983 • 45 citations

Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein

1990 • 39 citations

Nucleotide sequence of the pseudorabies virus immediate early gene, encoding a strong transactivator protein

1989 • 36 citations

Role for DNA-protein interaction in activation of the herpes simplex virus glycoprotein D gene

1988 • 29 citations

How different DNA sequences are recognized by a DNA-binding protein: effects of partial proteolysis

1989 • 17 citations