Endothelium-accelerated hyporesponsiveness of norepinephrine-elicited contraction of rat aorta in the presence of bacterial lipopolysaccharide

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1990 • 700 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

1990 • 455 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Identification of arginine as a precursor of endothelium-derived relaxing factor.

1988 • 407 citations

Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor.

1986 • 381 citations

A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applications

1985 • 286 citations

Enhanced responsiveness of rat isolated aorta to clonidine after removal of the endothelial cells

1984 • 225 citations

Incubation with endotoxin activates the L-arginine pathway in vascular tissue

1990 • 193 citations

Enhancement of alpha-1 and alpha-2 adrenergic agonist-induced vasoconstriction by removal of endothelium in rat aorta.

1985 • 163 citations

Phasic and tonic components in 5-HT2 receptor-mediated rat aorta contraction: participation of Ca++ channels and phospholipase C.

1985 • 115 citations

L-arginine evokes both endothelium-dependent and -independent relaxations in L-arginine-depleted aortas of the rat.

1991 • 110 citations

Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility. Association with vascular cytokine release.

1990 • 102 citations

Role of endothelium in the contractile response of rat aorta to α-adrenoceptor agonists

1985 • 101 citations

Endothelial mediated inhibition of contraction and increase in cyclic GMP levels evoked by the α‐adrenoceptor agonist B‐HT 920 in rat isolated aorta

1984 • 73 citations

L-Arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation

1989 • 66 citations

Effect of removing the endothelial cells on the reactivity of rat aortic segments to different ?-adrenoceptor agonists

1984 • 65 citations

Stretch may enhance the release of endothelium-derived relaxing factor in rabbit aorta

1990 • 27 citations

Desensitization of α-Adrenergic Receptor-Mediated Smooth Muscle Contraction

1991 • 20 citations

Endotoxin induces chronic prostaglandin and thromboxane synthesis from ureter-obstructed kidneys: role of inflammatory cells.

1983 • 14 citations

Tension-Induced Release of Endothelium-Derived Relaxing Factor; Possible Role in Establishment of Desensitization of Norepinephrine-Induced Contraction in Rat Aorta

1990 • 11 citations

Effects of prostaglandin I2 synthesized in the endothelium and in the smooth muscle on mechanical properties of the canine thoracic aorta

1986 • 5 citations

Induction of polymorphonuclear leukocyte-derived hepatocyte stimulating factor and effects on alpha 2-macroglobulin synthesis.

1989 • 3 citations

ENDOTHELIUM-DEPENDENT DESENSITIZATION OF AGONIST-INDUCED CONTRACTION OF VASCULAR SMOOTH MUSCLES

1990 • 3 citations