Urokinase-type plasminogen activator and its receptor in colorectal cancer: Independent prognostic factors of metastasis and cancer-specific survival and potential therapeutic targets

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Heterogeneity of malignant cells from a human colonic carcinoma.

1981 • 468 citations

Requirement for Specific Proteases in Cancer Cell Intravasation as Revealed by a Novel Semiquantitative PCR-Based Assay

1998 • 459 citations

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

1993 • 396 citations

Clinical Impact of the Plasminogen Activation System in Tumor Invasion and Metastasis: Prognostic Relevance and Target for Therapy

1997 • 391 citations

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

1989 • 341 citations

A new in vitro assay for quantitating tumor cell invasion.

1989 • 297 citations

Directed Plasminogen Activation at the Surface of Normal and Malignant Cells

1991 • 291 citations

Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to Prognosis

1999 • 287 citations

Urokinase overproduction results in increased skeletal metastasis by prostate cancer cells in vivo.

1994 • 225 citations

Urokinase plasminogen activator: A prognostic marker in multiple types of cancer

1999 • 199 citations

Mechanisms of tumour metastasis

1998 • 185 citations

The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy.

1994 • 171 citations

Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer.

1994 • 167 citations

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

1998 • 157 citations

Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer

1995 • 150 citations

Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer

1994 • 134 citations

Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice.

1995 • 131 citations

Survival in patients with large-bowel cancer

1990 • 127 citations

Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice

1998 • 126 citations

Interaction of Plasminogen Activators and Inhibitors with Plasminogen and Fibrin

1982 • 111 citations

Clinical and pathologic prognostic indicators in colorectal cancer. A population-based study.

1992 • 111 citations

In vitro inhibition of human glioblastoma cell line invasiveness by antisense uPA receptor

1997 • 102 citations

Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth.

1999 • 97 citations

Overexpression of urokinase receptor in breast cancer cells results in increased tumor invasion, growth and metastasis

1996 • 95 citations

Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patients

1996 • 82 citations

Association between plasma concentrations of plasminogen activator inhibitor-1 and survival in patients with colorectal cancer

1998 • 81 citations

Inhibition of invasion of HT1080 sarcoma cells expressing recombinant plasminogen activator inhibitor 2.

1993 • 78 citations

Increased plasminogen binding is associated with metastatic breast cancer cells: differential expression of plasminogen binding proteins

1998 • 72 citations

Antigen levels of urokinase plasminogen activator and its receptor at the tumor-host interface of colorectal adenocarcinomas are related to tumor aggressiveness

1995 • 67 citations

Management strategies for colorectal liver metastases — Part I

1997 • 56 citations

Clinicopathological Characteristics of Skipping Lymph Node Metastases in Patients with Colorectal Cancer

1998 • 50 citations

Higher expression of oncoproteins c-myc, c-erbB-2/neu, PCNA, and p53 in metastasizing colorectal cancer than in nonmetastasizing tumors

1996 • 49 citations

The plasmin system in human colonic tumors: An immunofluorescence study

1985 • 48 citations

The Plasminogen Activation System in Tumour Invasion and Metastasis

1996 • 45 citations

Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes' stage B and C colorectal cancer

1997 • 40 citations

Urokinase type plasminogen activator receptor expression in colorectal neoplasms

1998 • 37 citations

Tear fluid plasmin activity after excimer laser photorefractive keratectomy.

1994 • 31 citations

Association of Immunohistochemical Detection of Urokinase-Type Plasminogen Activator with Metastasis and Prognosis in Colorectal Cancer

1995 • 29 citations

Regulation of plasminogen activation by human U937 promonocytic cells.

1994 • 28 citations

Fibrinolysis components as prognostic markers in breast cancer and colorectal carcinoma.

1996 • 25 citations

The expression of p53, Ki‐67 and urokinase plasminogen activator receptor in colorectal adenomas with true invasion and pseudoinvasion

1999 • 17 citations

Pharmacokinetics and biodistribution of recombinant human plasminogen activator inhibitor type 2 (PAI-2) in control and tumour xenograft-bearing mice

1998 • 17 citations

Levels of plasminogen activator inhibitor type 1 and urokinase plasminogen activator receptor in non-small cell lung cancer as measured by quantitative ELISA and semiquantitative immunohistochemistry

1997 • 15 citations

In vivo overexpression of c-erbB-2 oncoprotein in xenografts of mice implanted with human colon cancer lines.

1997 • 11 citations

Elevation of Tear Fluid Plasmin Activity of Contact Lens Wearers Studied with a Rapid Fluorometric Assay

1994 • 10 citations

Blood and tissue fibrinolytic profiles in patients with colorectal carcinoma

1995 • 9 citations

Presence of urokinase plasminogen activator, its inhibitor and receptor in small cell lung cancer and non-small cell lung cancer

1997 • 6 citations