Langerhans Cells: Antigen Presenting Cells of the Epidermis

An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo**From the Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3, and the Departments of Anatomy, and Dermatology, St. Mary's Hospital Medical School (University of London) London, W. 2, England.

1961 • 812 citations

Immunologic Functions of Ia-Bearing Epidermal Langerhans Cells

1978 • 732 citations

Ueber die Nerven der menschlichen Haut

1868 • 678 citations

Dendritic Cells: Features and Functions

1980 • 585 citations

Epidermal Langerhans cells bear Fc and C3 receptors

1977 • 541 citations

The Regulatory Role of Macrophages in Antigenic Stimulation Part Two: Symbiotic Relationship between Lymphocytes and Macrophages

1981 • 518 citations

Antigen presentation: comments on its regulation and mechanism.

1984 • 498 citations

ANTIGENS IN IMMUNITY

1968 • 497 citations

Epidermal Langerhans cells express Ia antigens

1977 • 493 citations

Antigenicity of Murine Skin Tumors Induced by Ultraviolet Light2

1974 • 484 citations

Ultraviolet Light Depletes Surface Markers of Langerhans Cells

1981 • 474 citations

Skin-Associated Lymphoid Tissues (SALT): Origins and Functions.

1983 • 319 citations

The role of langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs

1976 • 304 citations

Relative efficacy of human monocytes and dendritic cells as accessory cells for T cell replication.

1983 • 300 citations

Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis

1983 • 246 citations

Expression of Thy-1 Antigen by Murine Epidermal Cells

1983 • 240 citations

The Fine Structure of the Melanocyte and Melanin Granule**From the Division of Dermatology, (Dr. F. W. Lynch, Director) and the Department of Anatomy, University of Minnesota Medical School, Minneapolis 14, Minnesota.Aided by research grants M-388 and B-782 from the National Institute of Mental Health and the National Institute for Neurologic Diseases and Blindness, U. S. Public Health Service, and by the Graduate Medical Research Fund of the University of Minnesota.

1961 • 232 citations

Corneal allografts fail to express Ia antigens

1979 • 227 citations

Analogous Functions of Macrophages and Langerhans Cells in the Initiation of the Immune Response

1978 • 216 citations

Apposition of mononuclear cells to langerhans cells in contact allergic reactions. An ultrastructural study

1973 • 208 citations

Mouse epidermal Ia molecules have a bone marrow origin

1979 • 203 citations

Lymphocyte Traffic, T-Cell Malignancies and the Skin

1978 • 197 citations

Langerhans Cells as Macrophages in Skin and Lymhphoid Organs

1980 • 195 citations

Detection of Ia Antigens on Langerhans Cells in Guinea Pig Skin

1978 • 193 citations

Ia Antigens in Mouse Skin Are Predominantly Expressed on Langerhans Cells

1979 • 185 citations

Relationship between epidermal Langerhans cell density ATPase activity and the induction of contact hypersensitivity.

1981 • 180 citations

Role of antigen-presenting cells in the development and persistence of contact hypersensitivity.

1980 • 174 citations

Surface Densities of Langerhans Cells in Relation to Rodent Epidermal Sites with Special Immunologic Properties

1980 • 173 citations

Antigen Presentation by Vascular Endothelial Cells and Epidermal Langerhans Cells: The Role of HLA‐DR

1982 • 173 citations

The Langerhans Cell1

2015 • 172 citations

The langerhans cell.

1972 • 167 citations

Cytochemical identification of ATPase-positive Langerhans cells in EDTA-separated sheets of mouse epidermis

2006 • 158 citations

A study of the branched cells of the mammalian epidermis with special reference to the fate of their division products

1953 • 153 citations

Special Review Article

1969 • 148 citations

Effect of glucocorticosteroids on epidermal Langerhans cells.

1982 • 146 citations

Immunoelectron Microscopic Identification of Langerhans Cells Using a New Antigenic Marker

1982 • 144 citations

Depletion of epidermal langerhans cells and Ia immunogenicity from tape-stripped mouse skin.

1982 • 141 citations

Fine-structural identification and organization of the epidermal proliferative unit

1974 • 131 citations

Quantitative Studies on the Langerhans Cell Population of Guinea Pig Epidermis**From the Section of Dermatology Mayo Clinic and Mayo Foundation and the Mayo Graduate School of Medicine University of Minnesota, Rochester, Minnesota.

1967 • 124 citations

A DEVELOPMENTAL STUDY OF THE DISTRIBUTION AND FREQUENCY OF LANGERHANS CELLS IN RELATION TO FORMATION OF PATTERNING IN MOUSE TAIL EPIDERMIS

1977 • 123 citations

Tissue Distribution of Ia Antigens and their Expression on Lymphocyte Subpopulations

1976 • 116 citations

Inability of UV-Irradiated Lymphocytes to Stimulate Allogeneic Cells in Mixed Lymphocyte Culture

1971 • 114 citations

Epidermal antigen-presenting cells in activation of suppression: identification of a new functional type of ultraviolet radiation-resistant epidermal cell.

1984 • 109 citations

Specialized antigen-presenting cells. Splenic dendritic cells and peritoneal-exudate cells induced by mycobacteria activate effector T cells that are resistant to suppression.

1982 • 109 citations

Induction of tolerance to topically applied TNCB using TNP-conjugated ultraviolet light-irradiated epidermal cells.

1981 • 106 citations

Langerhans Cells in Mouse Skin Experimentally Deprived of its Neural Crest Component*

1968 • 106 citations

The fine structure and cell kinetics of mouse epidermis after wounding

1975 • 98 citations

The effects of ultraviolet light and certain drugs on Ia-bearing Langerhans cells in murine epidermis

1981 • 94 citations

The Langerhans cell.

1981 • 91 citations

Langerhans Cells: Uptake of Tritiated Thymidine

1967 • 91 citations

Modulation of Expression of Epidermal Langerhans Cell Properties Following in Situ Exposure to Glucocorticosteroids

1983 • 90 citations

The Role of Epidermal Cells in the Induction and Suppression of Contact Sensitivity

1981 • 87 citations

Malignant histiocytosis: A case of generalized histiocytosis with infiltration of Langerhans' granule-containing histiocytes

1971 • 86 citations

Pulmonary Langerhans' cells in patients with fibrotic lung disorders.

1981 • 81 citations

Expression of Ia antigen-like molecules on cells in the corneal epithelium.

1979 • 74 citations

Expression of ia antigens by murine keratinizing epithelial langerhans cells

1978 • 73 citations

The Effects of 8-Methoxypsoralen and Long-wave Ultraviolet Light on Langerhans Cell

1981 • 72 citations

Biology of Langerhans cells: Selective migration of Langerhans cells into allogeneic and xenogeneic grafts on nude mice

1983 • 71 citations

Thy-1 Antigen-Bearing Dendritic Cells in Murine Epidermis Are Derived from Bone Marrow Precursors

1984 • 69 citations

Langerhans Cell Function Dictates Induction of Contact Hypersensitivity or Unresponsiveness to DNFB in Syrian Hamsters

1981 • 66 citations

Macrophages containing langerhans cell granules in normal lymph nodes of the rabbit

1969 • 63 citations

The Effect of Ultraviolet Radiation on Experimental Cutaneous Sensitization in Guinea-Pigs**From the Department of Dermatology and the Kettering Laboratory, College of Medicine, University of Cincinnati, Cincinnati, Ohio.

1963 • 63 citations

Epidermal Cell-Induced Generation of Cytotoxic T-Lymphocyte Responses Against Alloantigens or TNP-Modified Syngeneic Cells: Requirement for Ia-Positive Langerhans Cells

1983 • 62 citations

Cells Containing Birbeck Granules (Langerhans Cell Granules) in the Human Thymus

1970 • 61 citations

The Disappearance and Regeneration of Langerhans Cells following Epidermal Injury**From the Mayo Clinic and Mayo Foundation: Section of Dermatology and the Mayo Graduate School of Medicine (University of Minnesota), Rochester.

1968 • 61 citations

Electron microscope observations on Langerhans cells in the cervix

1968 • 60 citations

Labelling of murine epidermal Langerhans cells with H³‐Thymidine

1975 • 60 citations

Langerhans Cells: Functional Aspects Revealed by in Vivo Grafting Studies

1980 • 52 citations

The influence of ultraviolet radiation on allergic contact dermatitis in the guinea-pig. I. UVB radiation

1981 • 46 citations

Langerhans Cells in Epidermoid Metaplasia

1971 • 42 citations

Electron microscopic study of the development of the mouse corneal epithelium.

1971 • 41 citations

Significant changes in epidermal Langerhans cells of guinea-pigs infested with ticks (Dermacentor andersoni).

1984 • 35 citations

On the Ia immunogenicity of mouse corneal allografts infiltrated with Langerhans cells.

1984 • 34 citations

STIMULATION OF ALLOGENEIC LYMPHOCYTES BY SKIN EPIDERMAL CELLS IN THE RAT

1979 • 34 citations

IMPAIRMENT OF ANTIGEN-PRESENTING CELL FUNCTION BY ULTRAVIOLET RADIATION II. EFFECT OF IN VITRO ULTRAVIOLET IRRADIATION ON ANTIGEN-PRESENTING CELLS

1981 • 32 citations

Interepithelial cells of the oral mucosa in mice

1979 • 29 citations

The Effects of Ultraviolet Radiation on the Immune System

1984 • 24 citations

Lymphocyte Activating Alloantigens on Human Epidermal Cells

1975 • 24 citations

Langerhans cells in the ruminal epithelium of the sheep

1973 • 22 citations

Effects of ultraviolet irradiation on the acquisition and expression of tick resistance in guinea-pigs.

1984 • 21 citations

INDUCTION OF H-2-RESTRICTED CONTACT HYPERSENSITIVITY BY HAPTEN-DERIVATIZED SKIN GRAFTS

1984 • 20 citations

Histochemical analysis of Langerhansʼ cells

1979 • 18 citations

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