Determination of cross tolerance in rat spinal cord using intrathecal infusion via sequential mini-osmotic pumps

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

A method for measurement of analgesic activity on inflamed tissue.

1957 • 1,558 citations

Analgesia Mediated by a Direct Spinal Action of Narcotics

1976 • 945 citations

Pain Relief by Intrathecally Applied Morphine in Man

1979 • 944 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

EPIDURAL MORPHINE IN TREATMENT OF PAIN

1979 • 637 citations

Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing

1985 • 586 citations

Spinal opiate analgesia: Characteristics and principles of action

1981 • 552 citations

Studies in the Primate on the Analgetic Effects Associated with Intrathecal Actions of Opiates,α-Adrenergic Agonists and Baclofen

1981 • 533 citations

Spinal serotonin terminal system mediates antinociception

1981 • 504 citations

MOLECULAR BASIS FOR MILD FORMS OF HOMOZYGOUS BETA-THALASSAEMIA

1981 • 487 citations

Spinal cord pharmacology of adrenergic agonist-mediated antinociception.

1980 • 428 citations

Spinal noradrenergic terminal system mediates antinociception

1980 • 317 citations

The Physiology and Pharmacology of Spinal Opiates

1985 • 303 citations

Modification of Morphine Withdrawal by Drugs interacting with Humoral Mechanisms: Some Contradictions and their Interpretation

1972 • 233 citations

Subarachnoid Distribution of Drugs after Lumbar Injection

1962 • 217 citations

Microelectrometric titration measurement of the pKa's and partition and drug distribution coefficients of narcotics and narcotic antagonists and their pH and temperature dependence

1975 • 208 citations

DEVELOPMENT AND LOSS OF TOLERANCE TO MORPHINE IN THE RAT AFTER SINGLE AND MULTIPLE INJECTIONS.

1964 • 200 citations

Induction of tolerance and withdrawal in rats receiving morphine in the spinal subarachnoid space

1977 • 143 citations

Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens

1980 • 129 citations

Benefit from and tolerance to continuous intrathecal infusion of morphine for intractable cancer pain

1982 • 98 citations

Pharmacokinetic aspects of spinal morphine analgesia

1984 • 84 citations

Role of spinal mu opioid receptors in the development of morphine tolerance and dependence.

1984 • 71 citations

Spinal antagonism of tolerance and dependence induced by systemically administered morphine

1983 • 53 citations

Absence of Cross-Tolerance to Heroin in Morphine-Tolerant Mice

1980 • 49 citations

Intrathecal Clonidine

1985 • 49 citations

Time course of dependence and tolerance development in rats treated with "slow release" morphine suspensions.

1973 • 49 citations

Tolerance to the antinociceptive effect of morphine in the spinal rat

1981 • 43 citations

Tolerance and cross tolerance to morphine after chronic spinal D-Ala2-D-Leu5-enkephalin infusion

1982 • 41 citations

Withdrawal tolerance and unidirectional non-cross-tolerance in narcotic pellet-implanted mice.

1983 • 40 citations

Analgesia and tolerance to intrathecal morphine and norepinephrine infusion via implanted mini-osmotic pumps in the rat

1985 • 40 citations

Continuous intrathecal administration of morphine via an osmotic minipump in the rat

1982 • 32 citations

Analgesia and autonomic function following intrathecal administration of morphine and norepinephrine to the rat

1985 • 29 citations

Effect of depletion of spinal cord norepinephrine on morphine-induced antinociception

1986 • 27 citations

Morphine Tolerance and Dependence Induced by Intraventricular Injection

1971 • 23 citations

Partial cross tolerance to D-Ala2-D-Leu5-enkephalin after chronic spinal morphine infusion

1983 • 19 citations

A New Method for Studying the Distribution of Drugs in Spinal Cord after Intrathecal Injection

1984 • 12 citations