Involvement of the gonococcal MtrE protein in the resistance of Neisseria gonorrhoeae to toxic hydrophobic agents

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

Prediction of Protein Secondary Structure at Better than 70% Accuracy

1993 • 2,958 citations

Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux

1994 • 1,518 citations

Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

1993 • 722 citations

Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon

1993 • 685 citations

ABC transporters: bacterial exporters

1993 • 607 citations

Lipoproteins in bacteria

1990 • 536 citations

Molecular cloning and characterization of acrA and acrE genes of Escherichia coli

1993 • 459 citations

Methods and algorithms for statistical analysis of protein sequences.

1992 • 390 citations

Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system

1995 • 364 citations

Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport

1994 • 360 citations

Identification and arrangement of the DNA sequence recognized in specific transformation of Neisseria gonorrhoeae.

1988 • 349 citations

Triple post‐transcriptional control

1990 • 217 citations

Transport Proteins in Bacteria: Common Themes in Their Design

1992 • 200 citations

The Rhizobium nodulation gene nodO encodes a Ca2(+)-binding protein that is exported without N-terminal cleavage and is homologous to haemolysin and related proteins.

1990 • 177 citations

Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae

1995 • 176 citations

Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae

1975 • 169 citations

Regulation of the permeability of the gonococcal cell envelope by the mtr system

1994 • 161 citations

Analysis of the membrane organization of an Escherichia coli protein translocator, HlyB, a member of a large family of prokaryote and eukaryote surface transport proteins

1991 • 132 citations

Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids

1995 • 131 citations

Opacity determinants of Neisseria gonorrhoeae: Gene expression and chromosomal linkage to the gonococcal pilus gene

1984 • 131 citations

Gonococcal strains from homosexual men have outer membranes with reduced permeability to hydrophobic molecules

1982 • 119 citations

A family of small repeated elements with some transposon-like properties in the genome of Neisseria gonorrhoeae.

1988 • 117 citations

Nucleotide sequence analysis of a gene from Burkholderia (Pseudomonas) cepacia encoding an outer membrane lipoprotein involved in multiple antibiotic resistance

1996 • 115 citations

Cell envelope alterations in antibiotic-sensitive and-resistant strains of Neisseria gonorrhoeae

1978 • 103 citations

Identification and characterization of the TolC protein, an outer membrane protein from Escherichia coli

1983 • 69 citations

Rifampin resistance in Neisseria meningitidis due to alterations in membrane permeability

1996 • 63 citations

Molecular characterization of the nodulation gene, nodT, from two biovars of Rhizobium leguminosarum

1990 • 61 citations

Additive effect of tolC and rfa mutations on the hydrophobic barrier of the outer membrane of Escherichia coli K-12

1994 • 61 citations

Importance of lipooligosaccharide structure in determining gonococcal resistance to hydrophobic antimicrobial agents resulting from the mtr efflux system

1995 • 50 citations

Identification of an envelope mutation (env-10) resulting in increased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae

1984 • 39 citations