Exonic MHC‐DRB Polymorphisms and Intronic Simple Repeat Sequenees: Janus’Faces of DNA Sequence Evolution

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

1986 • 4,940 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.

1989 • 2,011 citations

Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

1988 • 1,968 citations

Mutation of human short tandem repeats

1993 • 1,584 citations

Informativeness of human (dC-dA)n · (dG-dT)n polymorphisms

1990 • 1,371 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

1989 • 893 citations

Mammalian phytogeny: shaking the tree

1992 • 656 citations

The natural history of the major histocompatibility complex

1987 • 500 citations

Origin of major histocompatibility complex polymorphism: The trans-species hypothesis

1987 • 450 citations

Conservation of polymorphic simple sequence loci in cetacean species

1991 • 371 citations

The Molecular Descent of the Major Histocompatibility Complex

1993 • 334 citations

The sequence (dC-dA)n X (dG-dT)n forms left-handed Z-DNA in negatively supercoiled plasmids.

1983 • 314 citations

Gene organization and recombinational hotspots in the murine major histocompatibility complex

1986 • 312 citations

HUMAN CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX GENES AND PROTEINS

1988 • 277 citations

Evolution of MHC genetic diversity: a tale of incest, pestilence and sexual preference

1993 • 259 citations

Evolution of diversity at the major histocompatibility complex

1990 • 214 citations

Notes on the definition and nomenclature of tandemly repetitive DNA sequences

1993 • 204 citations

HLA class II nucleotide sequences, 1992

1992 • 185 citations

On Simple Repeated GATCA Sequences in Animal Genomes: A Critical Reappraisal

1988 • 179 citations

Mining Treasures from 'Junk DNA'

1994 • 159 citations

The evolutionarily conserved repetitive sequence d(TG.AC)n promotes reciprocal exchange and generates unusual recombinant tetrads during yeast meiosis.

1986 • 146 citations

Characterization of an HLA DR beta pseudogene.

1985 • 138 citations

Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant.

1984 • 126 citations

Allelic diversity is generated by intraexon sequence exchange at the DRB1 locus of primates.

1991 • 124 citations

Genetic diversity at class II DRB loci of the primate MHC.

1991 • 115 citations

The synonymous substitution rate of the major histocompatibility complex loci in primates.

1993 • 81 citations

Exonic polymorphism vs intronic simple repeat hypervariability in MHC-DRB genes

1992 • 77 citations

Interdependent MHC-DRB exon-plus-intron evolution in artiodactyls.

1994 • 72 citations

Amplification of major histocompatibility complex class II gene diversity by intraexonic recombination.

1991 • 71 citations

His and hers recombinational hotspots

1991 • 68 citations

Evolution ofMHC polymorphism: Extensive sharing of polymorphic sequence motifs between human and bovine DRB alleles

1991 • 61 citations

Hypervariability of intronic simple (gt)n(ga)m repeats in HLA-DRB genes

1990 • 60 citations

Nucleotide sequence and Northern analysis of a bovine major histocompatibility class II DRß‐like cDNA

1991 • 60 citations

Molecular characterization of the recombination region of six murine major histocompatibility complex (MHC) I-region recombinants.

1984 • 59 citations

The paradox of MHC-DRB exon/intron evolution: ?-helix and ?-sheet encoding regions diverge while hypervariable intronic simple repeats coevolve with ?-sheet codons

1993 • 57 citations

Trans-species evolution of Mhc-DRB haplotype polymorphism in primates: Organization of DRB genes in the chimpanzee

1992 • 57 citations

The Generation and Maintenance of MHC Class II Gene Polymorphism in Rodents

1990 • 48 citations

Identification of genetic variation in the bovine major histocompatibility complex DRß-like genes using sequenced bovine genomic probes

1988 • 45 citations

Evolution of the Class II Major Histocompatibility Complex Alleles in Higher Primates

1990 • 45 citations

HLA class II nucleotide sequences, 1992

1993 • 45 citations

Nonhuman primate Mhc-DRB sequences: a compilation

1993 • 43 citations

Concordant evolution of coding and noncoding regions of DNA made possible by the universal rule of TA/CG deficiency-TG/CT excess.

1989 • 42 citations

Expression and characterization of ovine major histocompatibility complex class II (OLA‐DR) genes

1992 • 41 citations

The mouse E beta 2 gene: a class II MHC beta gene with limited intraspecies polymorphism and an unusual pattern of transcription.

1986 • 36 citations

Analysis of Recombinational Hot Spots Associated with the p Haplotype of the Mouse MHC

1994 • 33 citations

DNA sequences near a meiotic recombinational breakpoint within the human HLA-DQ region

1992 • 31 citations

A complex composed of at least two HeLa nuclear proteins protects preferentially one DNA strand of the simple (gt)_n(ga)_m containing region of intron 2 in HLA‐DRB‐genes

1994 • 18 citations

Genetic exchange in the evolution of the human MHC class II loci

1992 • 14 citations

A gel retardation assay system for studying protein binding to simple repetitive DNA sequences

1992 • 13 citations

Vb6 T-cell receptor elements in artiodactyls: conservation and germline polymorphisms

1993 • 13 citations

Human DNA sequences isolated with an immunoglobulin switch region probe: sequence, chromosomal localization, and restriction fragment length polymorphisms

1986 • 8 citations

Nomenclature for Factors of the HLA System, 1990

1991 • 5 citations