Anaphylaxis and the release of active substances in the lungs

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Prostaglandins: Their Disappearance from and Release into the Circulation

1967 • 898 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

Prostaglandins, Aspirin-like Drugs and Analgesia

1972 • 871 citations

The physiological action of β‐iminazolylethylamine

1910 • 867 citations

BRADYKININ, A HYPOTENSIVE AND SMOOTH MUSCLE STIMULATING FACTOR RELEASED FROM PLASMA GLOBULIN BY SNAKE VENOMS AND BY TRYPSIN

1949 • 815 citations

THE RELEASE OF PROSTAGLANDINS FROM LUNG AND OTHER TISSUES

1971 • 658 citations

The release and fate of vaso‐active hormones in the circulation

1969 • 639 citations

The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shock

1960 • 638 citations

Advances in Drug Research

1964 • 615 citations

The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones.

1966 • 573 citations

Inactivation of Prostaglandins by the Lungs

1970 • 517 citations

Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation

1973 • 485 citations

IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG

1972 • 462 citations

Histamine Release in vitro: Inhibition by Catecholamines and Methylxanthines

1968 • 458 citations

Selective Inhibitor of Slow Reacting Substance of Anaphylaxis

1973 • 443 citations

THE LIBERATION OF A SLOW‐REACTING SMOOTH MUSCLE‐STIMULATING SUBSTANCE IN ANAPHYLAXIS

1940 • 416 citations

Inhibition of prostaglandin biosynthesis

1974 • 402 citations

Hypotheses on physiological roles of prostaglandins.

1969 • 400 citations

The Distribution and Properties of a Histamine-methylating Enzyme

1959 • 371 citations

The action of peptides on the adrenal medulla. Release of adrenaline by bradykinin and angiotensin

1964 • 361 citations

IMMUNOLOGICAL RELEASE OF HISTAMINE AND SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM HUMAN LUNG

1971 • 338 citations

EFFECT OF A β-ADRENERGIC-BLOCKING AGENT, PROPRANOLOL, ON ASTHMATICS

1964 • 309 citations

Regulation of Tracheobronchial Smooth Muscle

1963 • 302 citations

Prostaglandins, peptides and amines,

1969 • 295 citations

The quantitative estimation of histamine in the blood

1937 • 283 citations

SIGNIFICANCE OF PHOSPHOLIPASE A FOR PROSTAGLANDIN FORMATION

1971 • 282 citations

Activity of lung irritant receptors in pulmonary micro‐embolism, anaphylaxis and drug‐induced bronchoconstrictions

1969 • 275 citations

AN EOSINOPHIL LEUKOCYTE CHEMOTACTIC FACTOR OF ANAPHYLAXIS

1971 • 266 citations

Actions of pure bradykinin

1960 • 252 citations

THE ACTION OF HISTAMINE ON THE RESPIRATORY TRACT IN NORMAL AND ASTHMATIC SUBJECTS 1

1946 • 252 citations

Effects of Prostaglandins on Human Bronchial Muscle

1968 • 240 citations

Selective Passage of Prostaglandins across the Lung

1969 • 236 citations

Slow Reacting Substance of Anaphylaxis

1969 • 230 citations

Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea‐pig lungs

1973 • 223 citations

REACTIONS OF ISOLATED HUMAN ASTHMATIC LUNG AND BRONCHIAL TISSUE TO A SPECIFIC ANTIGEN HISTAMINE RELEASE AND MUSCULAR CONTRACTION

1951 • 222 citations

PROSTAGLANDIN SYNTHETASE INHIBITORS

1979 • 220 citations

Pharmacokinetic function of the pulmonary circulation.

1974 • 216 citations

THE DISAPPEARANCE OF BRADYKININ AND ELEDOISIN IN THE CIRCULATION AND VASCULAR BEDS OF THE CAT

1967 • 212 citations

Inhibition by Sympathomimetic Amines of Histamine Release induced by Antigen in Passively Sensitized Human Lung

1969 • 201 citations

Biosynthesis of Prostaglandins from Arachidonic Acid in Guinea Pig Lung

1965 • 201 citations

Cyclic AMP, ATP, and Reversed Anaphylactic Histamine Release from Rat Mast Cells

1974 • 195 citations

Biological Effects of an Unsaturated Trihydroxy Acid (PGF_2α) from Normal Swine Lung Prostaglandin and Related Factors 13:

1963 • 172 citations

Metabolism of Prostaglandins

1977 • 170 citations

Immunologic release of histamine and slow reacting substance of anaphylaxis from human lung. V. Effects of prostaglandins on release of histamine.

1973 • 168 citations

The physicochemical characteristics and purification of slow-reacting substance of anaphylaxis.

1973 • 167 citations

The effect of calcium and pH on the anaphylactic reaction

1958 • 162 citations

Immunologic Release of Chemical Mediators from Human Nasal Polyps

1973 • 158 citations

Prostaglandin Regulation of Airway Smooth Muscle Tone

1973 • 158 citations

The Capacity of Human Immunoglobulin E to Mediate the Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) from Monkey Lung

1970 • 154 citations

Role of the vagus nerves in anaphylaxis and histamine‐induced bronchoconstrictions in guinea‐pigs

1970 • 147 citations

Pharmacologic Inhibition of the Antigen-Induced Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) from Monkey Lung Tissues Mediated by Human IgE

1971 • 141 citations

HISTAMINE RELEASE AND ANAPHYLACTIC SHOCK IN ISOLATED LUNGS OF GUINEA‐PIGS

1936 • 132 citations

Asthma: Physiology, immunopharmacology and treatment

1985 • 128 citations

Inactivation of bradykinin in the pulmonary circulation

1968 • 127 citations

Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) by IgE-Anti-IgE Reactions on Monkey Mast Cells

1972 • 127 citations

STUDIES ON THE ANALYSIS AND METABOLISM OF THE PROSTAGLANDINS

1971 • 126 citations

THE INHIBITORY ACTIONS OF PROSTAGLANDINS ON RESPIRATORY SMOOTH MUSCLE

1964 • 124 citations

THE BRONCHOCONSTRICTOR ACTION OF BRADYKININ IN THE GUINEA‐PIG

1960 • 122 citations

Studies on the mechanism of the hypertensive effect of prostaglandin F2-alpha.

1968 • 121 citations

ANTIBODIES INVOLVED IN ANTIGEN-INDUCED RELEASE OF SLOW REACTING SUBSTANCE OF ANAPHYLAXIS (SRS-A) IN THE GUINEA PIG AND RAT

1967 • 117 citations

Antigen Induced Release of Histamine and SRS-A from Human Lung passively sensitized with Reaginic Serum

1967 • 116 citations

THE PHYSIOLOGY OF THE IMMEDIATE REACTION OF ANAPHYLAXIS IN THE GUINEA-PIG

1910 • 115 citations

Effects of Anaphylactic Shock and Compound 48/80 on the Mast Cells of the Guinea Pig Lung

1956 • 115 citations

A COMPARISON OF THE BIOLOGICAL ACTIVITIES OF FOUR PROSTAGLANDINS

1963 • 114 citations

Inhibition of Allergic Reactions in Man and Other Species by Cromoglycate

1970 • 113 citations

The release of spasmogenic substances from human chopped lung tissue and its inhibition

1973 • 111 citations

HUMORAL FACTORS AFFECTING PULMONARY INFLATION DURING ACUTE ANAPHYLAXIS IN THE GUINEA‐PIG IN VIVO

1967 • 110 citations

Inactivation of slow reacting substance of anaphylaxins (SRS-A) by arylsulfatases.

1974 • 109 citations

Preformed eosinophil chemotactic factor of anaphylaxis (ECF-A).

1974 • 107 citations

INCREASED PLASMA LEVELS OF 15-KETO- 13,14-DIHYDRO-PROSTAGLANDIN F2α AFTER ALLERGEN-PROVOKED ASTHMA IN MAN

1974 • 107 citations

DISODIUM CROMOGLYCATE (INTAL)

1971 • 104 citations

Pulmonary Alveolar Hypoxia: Release of Prostaglandins and Other Humoral Mediators

1974 • 100 citations

THE RELEASE OF CATECHOLAMINES FROM THE ADRENAL MEDULLA PEPTIDES

1967 • 100 citations

Half-lives of Peptides and Amines in the Circulation

1967 • 99 citations

Inactivation of Slow Reacting Substance of Anaphylaxis (SRS-A) by Arylsulfatases

1974 • 95 citations

Cyclic nucleotides and modulation of effector systems of inflammation

1974 • 95 citations

Antagonism of some smooth muscle actions of prostaglandins by polyphloretin phosphate

1970 • 94 citations

Generation of prostaglandin E-like material by the guinea-pig trachea contracted by histamine

1975 • 90 citations

Circulating plasma kinin in patients with bronchial asthma

1967 • 89 citations

Effects of Bradykinin and Indomethacin on Cyclic GMP and Cyclic AMP in Lung Slices

1973 • 84 citations

Release of Catecholamines in the Guinea-pig by Substances involved in Anaphylaxis

1967 • 84 citations

Antihistamines in Bronchial Asthma

1949 • 82 citations

THE DETECTION AND ESTIMATION OF BRADYKININ IN THE CIRCULATING BLOOD

1967 • 77 citations

Disodium Cromoglycate

1970 • 74 citations

The relationship of histamine and 5‐hydroxytryptamine to anaphylactic shock in different species

1958 • 72 citations

Disodium cromoglycate. Activity in three in vitro models of the immediate hypersensitivity reaction in lung.

1970 • 71 citations

Acute systemic anaphylaxis in the calf

1973 • 71 citations

Release of prostaglandins, a prostaglandin metabolite, slow-reacting substance and histamine from anaphylactic lungs, and its modification by catecholamines

1974 • 68 citations

Potent bronchoconstrictor activity of 15-keto prostaglandin F2α

1974 • 68 citations

Observations on the ganglion-stimulating action of angiotensin and bradykinin.

1966 • 68 citations

Inhibition of the Release of Slow-Reacting Substance of Anaphylaxis in the Rat with Diethylcarbamazine

1968 • 66 citations

The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins

1972 • 66 citations

PHARMACOLOGICAL PROPERTIES OF SENSORY RECEPTORS AND THEIR RELATION TO THOSE OF THE AUTONOMIC NERVOUS SYSTEM

1957 • 65 citations

RELEASE OF KALLIKREIN FROM GUINEA PIG LUNG DURING ANAPHYLAXIS

1966 • 65 citations

Release of Histamine and Slow Reacting Substance with Mast Cell Changes after Challenge of Human Lung sensitized passively with Reagin in vitro

1967 • 65 citations

Effects histamine on pulmonary ventilation in man

1959 • 65 citations

Injury, Inflammation and Immunity

1962 • 64 citations

DISODIUM CROMOGLYCATE (INTAL)

1971 • 64 citations

Blockade by Polyphloretin Phosphate of the Prostaglandin F2α, Action on Isolated Human Bronchi

1971 • 63 citations

Inactivation of Bradykinin in Rat Lung

1970 • 62 citations

The use of the in vivo trachea preparation of the guinea-pig to assess drug action on lung

1969 • 61 citations

New Light on How Aspirin Works

1969 • 57 citations

The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat

1972 • 53 citations

Inactivation of bradykinin in rat lung

1969 • 53 citations

Release of prostaglandins and metabolites from guinea-pig lung: Inhibition by catecholamines

1973 • 52 citations

The molecular basis for the storage and release of histamine in rat mast cell granules

1974 • 52 citations

PROSTAGLANDIN INHIBITION WITH A DIBENZOXAZEPINE HYDRAZIDE DERIVATIVE AND MORPHINE

1971 • 50 citations

Antagonism by fenamates and like‐acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea‐pig

1968 • 48 citations

A rapid, simple method for isolating pinocytotic vesicles and plasma membrane of lung

1971 • 48 citations

Biologically Active Principles Occurring on Histamine Release from Cat Paw, Guinea Pig Lung and Isolated Rat Mast Cells

1963 • 48 citations

The continuous bioassay of the release and disappearance of histamine in the circulation

1973 • 47 citations

Bronchodilator activity of prostaglandin E2 when administered by aerosol to three species

1970 • 47 citations

ANTAGONISM BY MEFENAMIC AND FLUFENAMIC ACIDS OF THE BRONCHOCONSTRICTOR ACTION OF KININS IN THE GUINEA‐PIG

1963 • 47 citations

The Passive Transfer of Immediate Type Hypersensitivity from Man to Other Primates *

1965 • 44 citations

COMPARATIVE BIOASSAY OF PROSTAGLANDIN E₂ AND ITS THREE PULMONARY METABOLITES

1975 • 44 citations

ANAPHYLAXIS IN CHOPPED GUINEA PIG LUNG

1961 • 43 citations

Weitere Versuche über das Freiwerden eines histaminähnlichen Stoffes aus der durchströmten Lunge sensibilisierter Meerschweinchen beim Auslösen einer anaphylaktischen Lungenstarre

1933 • 41 citations

PROSTAGLANDIN INACTIVATION IN GUINEA‐PIG LUNG AND ITS INHIBITION

1974 • 41 citations

A dual action of histamine on guinea‐pig lung vessels

1972 • 40 citations

Production of kinins in bovine anaphylactic shock

1972 • 39 citations

Respiratory responses in subhuman primates with immediate type hypersensitivity.

1969 • 38 citations

Identification of asthma

1971 • 36 citations

Novel transformations of prostaglandin endoperoxides: formation of thromboxanes.

1976 • 36 citations

The inactivation of bradykinin in the pulmonary circulation of isolated lungs

1972 • 36 citations

Stimulation médullo-surrénalienne par la bradykinine

1961 • 35 citations

Inhibition of the Anaphylactic Release of Histamine from Chopped Guinea Pig Lung by Chymotrypsin Substrates and Inhibitors

1960 • 33 citations

The role of lung irritant receptors in respiratory responses to multiple pulmonary embolism, anaphylaxis and histamine-induced bronchoconstriction.

1969 • 33 citations

Pulmonary fate of vasoactive peptides in fetal, newborn, and adult sheep

1972 • 32 citations

Presence of Histamine H<sub>2</sub> -Receptors in the Guinea-Pig Pulmonary Vascular Bed

1973 • 32 citations

Glycogen, lipid, and high energy phosphate stores in hearts from conditioned rats.

1970 • 31 citations

Observations on the anti-anaphylactic activity of hydrocortisone and related steroids

1964 • 29 citations

Treatment of intractable asthma with diethylcarbamazine citrate.

1965 • 29 citations

Some effects of burimamide on the isolated perfused pulmonary circulation of the guinea‐pig

1973 • 28 citations

Formation and destruction of C14 histamine in human lung tissue in vitro

1960 • 28 citations

The Immunological Release of Slow-Reacting Substance of Anaphylaxis from Bovine Lung

1974 • 28 citations

Über die Stimulierung der Atmung durch Bradykinin und Kallidin

1964 • 27 citations

Anti-anaphylactic Action of Acetylsalicylate in Guinea Pig Lung

1963 • 26 citations

A Review of Immunological, Biochemical and Pharmacological Factors in the Release of Chemical Mediators from Human Lung

1973 • 26 citations

Vergleichende Untersuchungen über die bronchoconstrictorische und gefäßconstrictorische Wirkung des Bradykinins, Histamins und Serotonins an isolierten Lungenpräparaten

1964 • 26 citations

Photoconductivity in Black Lipid and Thin Lipid Membranes

1969 • 25 citations

Pulmonary fate of histamine, isoproterenol, physalaemin, and substance P

1970 • 24 citations

Detection of slow reacting substance of anaphylaxis (SRS-A) in plasma of guinea pigs during anaphylaxis.

1973 • 23 citations

Increased excretion of 5α,7α-dihydroxy-11-ketotetranor-prostanoic acid on anaphylaxis in the guinea-pig

1974 • 23 citations

METABOLISM OF [¹⁴C]‐HISTAMINE IN HEART‐LUNG‐LIVER PREPARATIONS OF CATS

1961 • 22 citations

Converting enzyme and bradykininase in the lung.

1972 • 22 citations

Release of spasmogenic substances induced by vasoactive amines from isolated lungs.

1972 • 22 citations

A COMPARISON OF THE EFFECTS OF PROSTAGLANDIN E₂ AND SALBUTAMOL BY INTRAVENOUS INFUSION ON THE AIRWAYS OBSTRUCTION OF PATIENTS WITH ASTHMA

1974 • 21 citations

CORTISONE AND ANAPHYLAXIS

1958 • 21 citations

Kinins and Ventilation of the Lungs

1970 • 21 citations

Release and metabolism of prostaglandins in lung tissue.

1974 • 20 citations

PROSTAGLANDINS AND ASTHMA

1975 • 20 citations

Modulation of the immunological release of the eosinophil chemotactic factor of anaphylaxis from human lung.

1974 • 19 citations

A comparison of immediate-type respiratory reactions to immunologic and pharmacologic agents in rhesus monkeys

1972 • 16 citations

Effect of diethylcarbamazine pamoate upon exercise-induced obstruction in asthmatic children.

1974 • 16 citations

Modification of acute systemic anaphylaxis in cattle by drugs and by vagotomy

1972 • 15 citations

THE EFFECT OF BUTAZOLIDINE ON THE ANAPHYLACTIC LUNG

1957 • 15 citations

INHIBITION OF THE PULMONARY INACTIVATION OF PROSTAGLANDINS in vivo BY DI‐4‐PHLORETIN PHOSPHATE

1975 • 14 citations

Asthma bronchiale und Histaminempfindlichkeit

1933 • 14 citations

Inhibition of Histamine and SRS-A from Monkey Lung Tissue by Chlorophenesin

1971 • 11 citations

PHYSIOLOGICAL STUDIES IN ANAPHYLAXIS: III. A MICROSCOPIC STUDY OF THE ANAPHYLACTIC LUNG OF THE GUINEA-PIG AND MOUSE

1911 • 11 citations

The role of slow-reacting substance in asthma.

1970 • 11 citations

Immunoglobulin E-mediated respiratory responses of subhuman primates. Reproducibility and effect of certain pharmacologic agents.

1970 • 11 citations

Endogenous broncho-active substances and their antagonism.

1970 • 9 citations

The immunologic release of chemical mediators from human nasal polyps

1973 • 8 citations

Inhibitory effects of aprotinin on kallikrein and kininases in dog's blood

1971 • 8 citations

Zur Frage der bronchoconstrictorischen Wirkung des Bradykinins, Kallidins und Eledoisins

1963 • 8 citations

Histamine release from the mast cells of guinea-pig lung

1967 • 7 citations

A preliminary investigation of prostaglandin synthetase activity in normal, sensitized and challenged sensitized guinea-pig lung.

1975 • 6 citations

Inhibition of Histamine Release and Formation of Slow Reacting Substance by Polyphloretin Phosphate

1973 • 5 citations

Treatment of anaphylaxis

1973 • 5 citations

Cellular and Physiologic Studies of Immediate-Type Respiratory Reactions

1973 • 5 citations

The release of 35-S-labelled material and SRS-A from immunologically challenged guinea-pig lungs.

1975 • 4 citations

BRONCHOGRAPHIC DEMONSTRATION OF THE BRONCHOCONSTRICTOR EFFECT OF BRADYKININ IN THE GUINEA-PIG.

1963 • 4 citations

Post-mortem findings in anaphylactic shock.

1971 • 4 citations

THE PROBABLE ROLE OF KNOWN MEDIATORS IN HYPERSENSITIVITY REACTIONS

1968 • 3 citations