Human and animal studies of schizophrenia-related gating deficits

Dementia Praecox and Paraphrenia.

1972 • 3,028 citations

Dementia Praecox oder Gruppe der Schizophrenien

1911 • 1,368 citations

Sensorimotor Gating and Schizophrenia

1990 • 1,307 citations

Disorders of attention and perception in early schizophrenia

1961 • 1,198 citations

Prestimulus Effects on Human Startle Reflex in Normals and Schizophrenics

1978 • 1,173 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

The More or Less Startling Effects of Weak Prestimulation

1975 • 1,113 citations

Prevalence of smoking among psychiatric outpatients

1986 • 1,059 citations

A primary acoustic startle circuit: lesion and stimulation studies

1982 • 947 citations

Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.

1982 • 888 citations

Assessing the Validity of an Animal Model of Deficient Sensorimotor Gating in Schizophrenic Patients

1994 • 702 citations

Schizophrenia, Sensory Gating, and Nicotinic Receptors

1998 • 697 citations

Normalization of auditory physiology by cigarette smoking in schizophrenic patients

1993 • 689 citations

Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

1987 • 682 citations

Dopaminergic stimulation disrupts sensorimotor gating in the rat

1988 • 609 citations

Using an Animal Model of Deficient Sensorimotor Gating to Study the Pathophysiology and New Treatments of Schizophrenia

1998 • 608 citations

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in alzheimer's disease

1992 • 478 citations

The slow response of the human cortex to auditory stimuli: Recovery process

1966 • 463 citations

Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease.

1995 • 445 citations

Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics

1992 • 417 citations

Startle Habituation and Sensorimotor Gating in Schizophrenia and Related Animal Models

1987 • 411 citations

DEMENTIA PRAECOX AND PARAPHRENIA

1921 • 397 citations

Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results

1996 • 396 citations

Deficits in Sensory Gating in Schizophrenic Patients and Their Relatives

1984 • 381 citations

Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia

1993 • 376 citations

Symptom Correlates of Prepulse Inhibition Deficits in Male Schizophrenic Patients

1999 • 372 citations

A preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder

1993 • 355 citations

Startle gating deficits occur across prepulse intensities in schizophrenic patients

1992 • 332 citations

Information-processing deficits and thought disorder in schizophrenia

1994 • 312 citations

Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder

1993 • 310 citations

Poor P50 Suppression Among Schizophrenia Patients and Their First-Degree Biological Relatives

1998 • 272 citations

Cholinergic gating of response to auditory stimuli in rat hippocampus

1992 • 264 citations

Sensory gating deficits in schizophrenia: new results

1992 • 263 citations

The neural substrates for the motor-activating properties of psychostimulants: A review of recent findings

1986 • 262 citations

Sensory gating in schizophrenics and normal controls: Effects of changing stimulation interval

1989 • 258 citations

Autoradiographic distribution of nicotine receptors in rat brain

1984 • 253 citations

Acoustic and Temporal Factors in the Evocation of Startle

1968 • 247 citations

Normalization of Information Processing Deficits in Schizophrenia With Clozapine

1999 • 244 citations

Neurophysiological studies of sensory gating in rats: Effects of amphetamine, phencyclidine, and haloperidol

1986 • 243 citations

Sensorimotor Gating and Thought Disturbance Measured in Close Temporal Proximity in Schizophrenic Patients

1999 • 241 citations

Inhibitory Gating of an Evoked Response to Repeated Auditory Stimuli in Schizophrenic and Normal Subjects

1996 • 241 citations

The Inhibitory Pathways of the Central Nervous System

1969 • 235 citations

Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine

1990 • 233 citations

Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs

1995 • 231 citations

Auditory sensory gating in hippocampal neurons: A model system in the rat

1990 • 225 citations

Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia

1993 • 213 citations

Normal P50 Suppression in Schizophrenia Patients Treated With Atypical Antipsychotic Medications

2000 • 209 citations

Neurophysiological studies of sensory gating in mania: comparison with schizophrenia.

1983 • 207 citations

Gating of auditory P50 in schizophrenics: Unique effects of clozapine

1996 • 203 citations

Genetic Correlation of Inhibitory Gating of Hippocampal Auditory Evoked Response and α-Bungarotoxin-Binding Nicotinic Cholinergic Receptors in Inbred Mouse Strains

1996 • 202 citations

Sensory Gating Deficits Assessed by the P50 Event-Related Potential in Subjects With Schizotypal Personality Disorder

2000 • 200 citations

Prepulse inhibition and latent inhibition: the role of dopamine in the medial prefrontal cortex

1996 • 194 citations

Replication and Extension of P50 Findings in Schizophrenia

1991 • 190 citations

The Dopamine D₂, but not D₃or D₄, Receptor Subtype is Essential for the Disruption of Prepulse Inhibition Produced by Amphetamine in Mice

1999 • 179 citations

Latency and amplitude changes in the acoustic startle reflex of the rat produced by variation in auditory prestimulation☆

1973 • 176 citations

P50 Suppression among schizophrenia and normal comparison subjects: A methodological analysis

1997 • 169 citations

Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats

1992 • 160 citations

Cross‐species Studies of Sensorimotor Gating of the Startle Reflex

1999 • 156 citations

P50 abnormalities in schizophrenia: relationship to clinical and neuropsychological indices of attention

1998 • 149 citations

Sensorimotor gating and habituation evoked by electro-cutaneous stimulation in schizophrenia

1994 • 149 citations

The effects of low dose ketamine on sensory gating, neuroendocrine secretion and behavior in healthy human subjects

1998 • 145 citations

Prestimulation‐Induced Startle Modulation in Attention‐Deficit Hyperactivity Disorder and Nocturnal Enuresis

1992 • 137 citations

Elementary phenotypes in the neurobiological and genetic study of schizophrenia

1999 • 136 citations

Reversal of Isolation Rearing-Induced Deficits in Prepulse Inhibition by Seroquel and Olanzapine

1998 • 136 citations

Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis

1996 • 136 citations

Codistribution of a sensory gating deficit and schizophrenia in multi-affected families

1991 • 131 citations

Normalizing Effects of Nicotine and a Novel Nicotinic Agonist on Hippocampal Auditory Gating in Two Animal Models

1997 • 129 citations

Effect of cigarette smoking on prepulse inhibition of the acoustic startle reflex in healthy male smokers

1996 • 124 citations

Prepulse inhibition of startle and the neurobiology of primary nocturnal enuresis

1999 • 124 citations

P50 suppression in recent-onset schizophrenia: Clinical correlates and risperidone effects.

1998 • 121 citations

Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects

1998 • 114 citations

Effects of P50 temporal variability on sensory gating in schizophrenia

1997 • 114 citations

Sensory gating deficits in psychiatric impatients: Relation to catecholamine metabolites in different diagnostic groups

1990 • 114 citations

Midlatency auditory evoked responses in schizophrenia

1991 • 113 citations

Nicotinic receptor desensitization and sensory gating deficits in schizophrenia

1998 • 106 citations

Auditory P50 in Schizophrenics on Clozapine: Improved Gating Parallels Clinical Improvement and Changes in Plasma 3-Methoxy-4-Hydroxyphenylglycol

1999 • 103 citations

Effect of acute subcutaneous nicotine on prepulse inhibition of the acoustic startle reflex in healthy male non-smokers

1997 • 97 citations

Dopaminergic and noradrenergic modulation of amphetamine-induced changes in auditory gating

1991 • 96 citations

Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population

1999 • 96 citations

P50 suppression in recent-onset schizophrenia: Clinical correlates and risperidone effects.

1998 • 96 citations

Differential effects of ketamine on gating of auditory evoked potentials and prepulse inhibition in rats

1999 • 96 citations

Modulation of the gating of auditory evoked potentials by norepinephrine: Pharmacological evidence obtained using a selective neurotoxin

1988 • 86 citations

The Inhibitory Pathways of the Central Nervous System

1970 • 84 citations

Amphetamine disrupts P50 suppression in normal subjects

1999 • 82 citations

Behavioral Studies of Hallucinogenic Drugs in Animals: Implications for Schizophrenia Research

1998 • 81 citations

Sensory gating deficits in parents of schizophrenics

1995 • 73 citations

Replication of a P50 auditory gating deficit in Australian patients with schizophrenia

1996 • 60 citations

Prepulse inhibition of the acoustic startle reflex using visual and auditory prepulses: disruption by apomorphine

1995 • 58 citations

Towards a cross-species pharmacology of sensorimotor gating: effects of amantadine, bromocriptine, pergolide and ropinirole on prepulse inhibition of acoustic startle in rats

1998 • 56 citations

Effects of bromocriptine and haloperidol on prepulse inhibition: comparison of the acoustic startle eyeblink response and the N1/P2 auditory-evoked response in man

1999 • 54 citations

Restoration of sensory gating of auditory evoked response by nicotine in fimbria-fornix lesioned rats

1995 • 54 citations

Rats Reared in Social Isolation Show Schizophrenia-Like Changes in Auditory Gating

1997 • 52 citations

Disruption of sensory gating by the α2 selective noradrenergic antagonist yohimbine

1993 • 50 citations

5-Hydroxytryptamine2 receptors modulate auditory filtering in the rat.

1998 • 42 citations

Lack of sensitization to the effects of d -amphetamine and apomorphine on sensorimotor gating in rats

1998 • 36 citations

Effects of neonatal dopamine depletion on sensory inhibition in the rat

1996 • 32 citations

Kainic acid lesions in adult rats as a model of schizophrenia: changes in auditory information processing

1997 • 30 citations

Inhibition of nitric oxide synthase prevents α7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus

2000 • 30 citations

Inhibition of nitric oxide synthase disrupts inhibitory gating of auditory responses in rat hippocampus.

1998 • 16 citations