Allogeneic transplantation of blood stem cells: Coming of age?

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

1998 • 1,984 citations

Treatment of High-Risk Acute Leukemia with T-Cell–Depleted Stem Cells from Related Donors with One Fully Mismatched HLA Haplotype

1998 • 1,200 citations

Engraftment of Allogeneic Hematopoietic Progenitor Cells With Purine Analog-Containing Chemotherapy: Harnessing Graft-Versus-Leukemia Without Myeloablative Therapy

1997 • 1,200 citations

T-cell depletion of HLA-identical transplants in leukemia

1991 • 771 citations

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

2000 • 679 citations

Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor [see comments]

1995 • 616 citations

Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells

2000 • 560 citations

Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts [see comments]

1995 • 557 citations

Engraftment Kinetics After Nonmyeloablative Allogeneic Peripheral Blood Stem Cell Transplantation: Full Donor T-Cell Chimerism Precedes Alloimmune Responses

1999 • 547 citations

Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease

1995 • 535 citations

Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1

2000 • 420 citations

Randomized Trial of Bone Marrow Versus Lenograstim-Primed Blood Cell Allogeneic Transplantation in Patients With Early-Stage Leukemia: A Report From the Société Française de Greffe de Moelle

2000 • 391 citations

Improved immune reconstitution after allotransplantation of peripheral blood stem cells instead of bone marrow

1996 • 374 citations

Epstein-Barr virus (EBV) load in bone marrow transplant recipients at risk to develop posttransplant lymphoproliferative disease: prophylactic infusion of EBV-specific cytotoxic T cells

2000 • 335 citations

G‐CSF‐mobilized peripheral blood progenitor cells for allogeneic transplantation: safety, kinetics of mobilization, and composition of the graft

1994 • 295 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 293 citations

Allogeneic bone marrow transplantation vs filgrastim-mobilised peripheral blood progenitor cell transplantation in patients with early leukaemia: first results of a randomised multicentre trial of the European Group for Blood and Marrow Transplantation

1998 • 276 citations

Allogeneic blood stem cell transplantation: peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy- 1dim) and lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease

1995 • 273 citations

Autologous progenitor cell transplantation: prior exposure to stem cell- toxic drugs determines yield and engraftment of peripheral blood progenitor cell but not of bone marrow grafts

1995 • 235 citations

Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts

1996 • 231 citations

A randomised, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of haematological malignancies

1998 • 213 citations

Suppression of Alloantigen-Induced T-Cell Proliferation by CD14+ Cells Derived From Granulocyte Colony-Stimulating Factor–Mobilized Peripheral Blood Mononuclear Cells

1997 • 202 citations

Allogeneic peripheral blood stem cell transplantation using a fludarabine-based low intensity conditioning regimen for malignant lymphoma

2000 • 192 citations

Peripheral Blood Stem Cell Transplantation From Unrelated Donors: A Comparison With Marrow Transplantation

1999 • 188 citations

Syngeneic transplantation with peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony-stimulating factor

1993 • 183 citations

Lymphoid Reconstitution After Autologous PBSC Transplantation With FACS-Sorted CD34+ Hematopoietic Progenitors

1998 • 183 citations

Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells.

1997 • 180 citations

Transplantation of allogeneic CD34+ peripheral blood stem cells in patients with advanced hematologic malignancy

1996 • 163 citations

T cell-depleted bone marrow transplantation and delayed T cell add-back to control acute GVHD and conserve a graft-versus-leukemia effect

1998 • 159 citations

Transplantation of allogeneic CD34+ blood cells

1996 • 156 citations

A randomised study of allogeneic transplantation with stem cells from blood or bone marrow

2000 • 140 citations

High incidence of chronic GVHD after primary allogeneic peripheral blood stem cell transplantation in patients with hematologic malignancies.

1996 • 125 citations

Rapid Engraftment Without Significant Graft-Versus-Host Disease After Allogeneic Transplantation of CD34+ Selected Cells From Peripheral Blood

1997 • 124 citations

Lymphocyte reconstitution after allogeneic blood stem cell transplantation for hematologic malignancies

1998 • 114 citations

Peripheral blood stem cell mobilization and apheresis: analysis of adverse events in 94 normal donors

1999 • 105 citations

The Risk of Residual Molecular and Cytogenetic Disease in Patients With Philadelphia-Chromosome Positive First Chronic Phase Chronic Myelogenous Leukemia Is Reduced After Transplantation of Allogeneic Peripheral Blood Stem Cells Compared With Bone Marrow

1999 • 103 citations

Natural Killer (NK) Cells Are Functionally Abnormal and NK Cell Progenitors Are Diminished in Granulocyte Colony-Stimulating Factor–Mobilized Peripheral Blood Progenitor Cell Collections

1997 • 103 citations

Preliminary Results of Treatment with Filgrastim for Relapse of Leukemia and Myelodysplasia after Allogeneic Bone Marrow Transplantation

1993 • 99 citations

Bone marrow transplantation for refractory acute leukemia in 34 patients with identical twins

1981 • 93 citations

Alloantigen presenting capacity, T cell alloreactivity and NK function of G-CSF-mobilized peripheral blood cells

1998 • 93 citations

Peripheral blood vs bone marrow as a source for allogeneic hematopoietic stem cell transplantation

1999 • 84 citations

Dose-reduced conditioning for allogeneic blood stem cell transplantation: durable engraftment without antithymocyte globulin

2000 • 81 citations

CD34+ cell dose predicts relapse and survival after T‐cell‐depleted HLA‐identical haematopoietic stem cell transplantation (HSCT) for haematological malignancies

2000 • 80 citations

Transplantation of Filgrastim-Mobilized Peripheral Blood Stem Cells From HLA-Identical Sibling or Alternative Family Donors in Patients With Hematologic Malignancies: A Prospective Comparison on Clinical Outcome, Immune Reconstitution, and Hematopoietic Chimerism

1997 • 78 citations

THE PLACE OF BLOOD STEM CELLS IN ALLOGENEIC TRANSPLANTATION

1996 • 76 citations

G-CSF-mobilized peripheral blood progenitor cells for allogeneic transplantation: comparison of T cell depletion strategies using different CD34+ selection systems or CAMPATH-1.

1995 • 76 citations

Preliminary experience of allogeneic stem cell transplantation for lymphoproliferative disorders using BEAM–CAMPATH conditioning: an effective regimen with low procedure‐related toxicity

2000 • 74 citations

The Role of Blood Stem Cells in Hematopoietic Cell Renewal

1998 • 64 citations

Allogeneic Peripheral Blood Progenitor Cell Transplantation in a Murine Model: Evidence for an Improved Graft-Versus-Leukemia Effect

1997 • 61 citations

Graft‐versus‐leukaemia activity can be predicted by natural cytotoxicity against leukaemia cells

1996 • 61 citations

Allogeneic MHC‐mismatched activated natural killer cells administered after bone marrow transplantation provide a strong graft‐versus‐leukaemia effect in mice

1997 • 56 citations

G-CSF-Induced Mobilization of Peripheral Blood Stem Cells from Healthy Adults for Allogeneic Transplantation

1996 • 55 citations

Autografting of highly purified peripheral blood progenitor cells following myeloablative therapy in patients with lymphoma: a prospective study of the long-term effects on tumor eradication, reconstitution of hematopoiesis and immune recovery

1999 • 50 citations

Improved Reconstitution of CD4 T Cells and B Cells But Worsened Reconstitution of Serum IgG Levels After Allogeneic Transplantation of Blood Stem Cells Instead of Marrow

1997 • 49 citations

Quantitative lymphocyte subset reconstitution after allogeneic hematopoietic transplantation from matched related donors with CD34+ selected PBPC grafts, unselected PBPC grafts or BM grafts

1999 • 48 citations

Definition of a critical T cell threshold for prevention of GVHD after HLA non-identical PBPC transplantation in children

1999 • 46 citations

Immunobiology of allogeneic peripheral blood mononuclear cells mobilized with granulocyte-colony stimulating factor

2000 • 46 citations

Allogeneic peripheral blood progenitor cells for treatment of relapse after bone marrow transplantation

1997 • 32 citations

The evolution of clinical peripheral blood stem cell transplantation.

1996 • 31 citations

Allogeneic peripheral stem cell transplantation using positively selected CD34+ cells from HLA-mismatched donors

1998 • 30 citations

Granulocyte colony-stimulating factor mobilizes into peripheral blood the complete clonal repertoire of hematopoietic precursors residing in the bone marrow of mice

1996 • 29 citations

SPECIFIC RECOGNITION OF HUMAN LEUKEMIC CELLS BY ALLOGENEIC T CELL LINES

1989 • 28 citations

Treatment of poor marrow graft function with allogeneic CD34+ cells immunoselected from G-CSF-mobilized peripheral blood progenitor cells of the marrow donor.

1994 • 24 citations

Administration of G-CSF to normal individuals diminishes L-selectin+ T cells in the peripheral blood that respond better to alloantigen stimulation than L-selectin− T cells

1999 • 22 citations

Single leukapheresis products collected from healthy donors after the administration of granulocyte colony-stimulating factor contain ten-fold higher numbers of long-term reconstituting hematopoietic progenitor cells than conventional bone marrow allografts

1999 • 22 citations

Treatment of normal donors with recombinant growth factors for transplantation of allogeneic blood stem cells.

1996 • 21 citations

The impact of the composition of the bone marrow graft on engraftment and graft-versus-host disease.

1983 • 18 citations

Transplantation of allogeneic peripheral blood stem cells

1995 • 17 citations

Granulocyte colony-stimulating factor-mobilized allogeneic peripheral blood stem cells for rescue graft failure after allogeneic bone marrow transplantation in two patients with acute myeloblastic leukemia in first complete remission [letter]

1995 • 17 citations

Successful engraftment after primary graft failure in aplastic anemia using G-CSF mobilized peripheral stem cell transfusions

1997 • 14 citations

A retrospective Dutch study comparing T cell-depleted allogeneic blood stem cell transplantation vs T cell-depleted allogeneic bone marrow transplantation.

1998 • 12 citations

Selection of CD34-Positive Blood Cells for Allogeneic Transplantation: Approaches to Optimize D34-Cell Recovery, Purity, Viability, and T-cell Depletion

2000 • 11 citations

Hematopoietic stem cell transplantation in Europe 1998

2000 • 10 citations

Superior antileukemic activity of murine peripheral blood progenitor cell (PBPC) grafts mobilized by G-CSF and stem cell factor (SCF) as compared to G-CSF alone.

1998 • 10 citations

Faster engraftment of peripheral blood progenitor cells compared to bone marrow from unrelated donors.

1998 • 9 citations

Transplantation of allogeneic peripheral blood stem cells.

1996 • 8 citations

Stem Cell Mobilization in Healthy Donors: Current Status

1999 • 6 citations