Recruitment of host CD8+ T cells by tumor-infiltrating lymphocytes and recombinant interleukin-2 during adoptive immunotherapy of cancer*

A generalized Wilcoxon test for comparing arbitrarily singly-censored samples

1965 • 3,333 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

The biology of interleukin-6

1989 • 1,964 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

Immunotherapy of patients with advanced cancer using tumor-infiltrating lymphocytes and recombinant interleukin-2: a pilot study.

1988 • 432 citations

Accurate Identification of Experimental Pulmonary Metastases2

1966 • 418 citations

Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes.

1991 • 402 citations

Successful immunotherapy of murine experimental hepatic metastases with lymphokine-activated killer cells and recombinant interleukin 2.

1985 • 376 citations

T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor.

1980 • 373 citations

Expansion of human tumor infiltrating lymphocytes for use in immunotherapy trials

1987 • 361 citations

The anti-tumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo.

1985 • 293 citations

In Vivo Antitumor Activity of Tumor-Infiltrating Lymphocytes Expanded in Recombinant Interleukin-2

1987 • 250 citations

"Anomalous" THY-1(+) killer cells in allogeneic and F1-anti-parental mixed leukocyte culture. Relation to natural killer cells and allospecific cytotoxic T lymphocytes

1982 • 237 citations

Identification of cellular mechanisms operational in vivo during the regression of established pulmonary metastases by the systemic administration of high-dose recombinant interleukin 2.

1987 • 211 citations

Lysis of Autologous Melanoma Cells by Tumor*Infiltrating Lymphocytes: Association With Clinical Response

1991 • 196 citations

Direct activation of human resting T cells by IL 2: the role of an IL 2 receptor distinct from the Tac protein.

1987 • 179 citations

Regression of an established tumor genetically modified to release granulocyte colony-stimulating factor requires granulocyte-T cell cooperation and T cell-produced interferon gamma.

1993 • 171 citations

Adoptive immunotherapy of newly induced murine sarcomas.

1985 • 137 citations

Synergistic antitumor activity of tumor-infiltrating lymphocytes, interleukin 2, and local tumor irradiation. Studies on the mechanism of action.

1990 • 118 citations

T cell-mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases.

1981 • 118 citations

Defective presentation of endogenous antigens by a murine sarcoma. Implications for the failure of an anti-tumor immune response.

1991 • 114 citations

Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice.

1992 • 111 citations

Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell-mediated suppression of immunity.

1984 • 86 citations

A comparative morphological study of the mammary gland in a high and a low tumor strain of mice.

1938 • 77 citations

Generation of T-Cells Reactive to the Poorly Immunogenic B16-BL6 Melanoma with Efficacy in the Treatment of Spontaneous Metastases

1993 • 59 citations

Serologic Identification of Multiple Tumor-Associated Antigens on Murine Sarcomas

1977 • 47 citations

A New Regimen of Interleukin 2 and Lymphokine-Activated Killer Cells

1988 • 41 citations

Solid-phase anti-CD3 antibody activation of murine tumor-infiltrating lymphocytes.

1990 • 38 citations

Reactivation of murine tumour-infiltrating lymphocytes with solid-phase anti-CD3 antibody: in vitro cytokine production is associated with in vivo efficacy

1994 • 35 citations

Immunomodulatory effects of systemic low-dose recombinant interleukin-2 and lymphokine-activated killer cells in humans

1989 • 17 citations

Generation of lymphokine-activated killer cells does not require DNA synthesis.

1987 • 14 citations

The biological effects of immunosuppression on cellular immunotherapy

1992 • 10 citations

Activation of CD8+ Murine T Cells from Tumor-Draining Lymph Nodes by Phorbol Dibutyrate plus Calcium Ionophore

1992 • 7 citations