Mutational Analysis of the P-Glycoprotein First Intracellular Loop and Flanking Transmembrane Domains

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Inorganic and organic phosphate measurements in the nanomolar range

1987 • 726 citations

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1993 • 496 citations

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

1990 • 386 citations

A simple and efficient method for direct cloning of PCR products using ddT-tailed vectors

1991 • 381 citations

A mouse model for the cystic fibrosis delta F508 mutation.

1995 • 234 citations

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12

1993 • 194 citations

Transmembrane Organization of Mouse P-glycoprotein Determined by Epitope Insertion and Immunofluorescence

1996 • 142 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Functional expression of P-glycoproteins in secretory vesicles.

1994 • 134 citations

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.

1992 • 114 citations

Effect of Cystic Fibrosis-associated Mutations in the Fourth Intracellular Loop of Cystic Fibrosis Transmembrane Conductance Regulator

1996 • 98 citations

Defective H+-ATPase of Hygromycin B-resistant pma1 Mutants from Saccharomyces cerevisiae

1989 • 93 citations

P-glycoprotein-mediated multidrug resistance in tumor cells: Biochemistry, clinical relevance and modulation

1995 • 81 citations

Functional Dissection of P-glycoprotein Nucleotide-binding Domains in Chimeric and Mutant Proteins

1995 • 78 citations

Residues in TAP2 peptide transporters controlling substrate specificity.

1996 • 77 citations

Functional Expression of the Multidrug Resistance-associated Protein in the Yeast Saccharomyces cerevisiae

1996 • 36 citations