L.H. Gray medal lecture: Cell kinetics and radiation oncology

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

Cell population kinetics in the intestinal epithelium of the mouse

1959 • 1,446 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Control of proliferation in animal cells

1974 • 1,177 citations

Dynamics of Tumor Growth

1964 • 815 citations

Radiation Biology in Cancer Research

1980 • 782 citations

Observations on growth rates of human tumors.

1956 • 759 citations

Growth Kinetics of Tumours

1978 • 691 citations

Clonal origin of human tumors

1976 • 662 citations

Cancer of the breast: Size of neoplasm and prognosis

1969 • 491 citations

Ten year follow-up results of patients with carcinoma of the breast in a co-operative clinical trial evaluating surgical adjuvant chemotherapy.

1975 • 367 citations

Radiation biology in cancer research

1978 • 340 citations

Relation between the pathological nature and the growth rate of human tumors

1971 • 310 citations

Nuclear incorporation of P as demonstrated by autoradiographs

1951 • 302 citations

The influence of the number of fractions and of overall treatment time on local control and late complication rate in squamous cell carcinoma of the larynx

1983 • 289 citations

The metastatic patterns of osteosarcoma

1975 • 264 citations

Experimental radiotherapy of a rat rhabdomyosarcoma with 15 MeV neutrons and 300 kV X-rays

1970 • 260 citations

A re-evaluation of split-course technique for squamous cell carcinoma of the head and neck

1980 • 258 citations

Natural History of Untreated Breast Cancer (1805-1933)

1962 • 252 citations

Changes in the rate of repopulation during multifraction irradiation of mouse skin

1973 • 247 citations

Growth Kinetics and Biochemical Regulation of Normal and Malignant Cells

1978 • 246 citations

Cell kinetics and chemotherapy: a critical review.

1978 • 224 citations

Kinetics of tumor growth and regression in IgG multiple myeloma

1972 • 217 citations

Growth Kinetics of Tumours: Cell Population Kinetics in Relation to the Growth and Treatment of Cancer

1978 • 207 citations

Growth rate of 147 mammary carcinomas

1980 • 200 citations

The gross rates of growth of human mammary carcinoma

1972 • 198 citations

Growth Rate Patterns of Solid Tumors and Their Relation to Responsiveness to Therapy

1978 • 195 citations

Repair of Potentially Lethal Radiation DamageIn VitroandIn Vivo

1973 • 194 citations

Rates of Growth of Pulmonary Metastases and Host Survival

1964 • 188 citations

Prognostic significance of tumor doubling time in evaluating operability in pulmonary metastatic disease

1971 • 186 citations

The relationship between growth rate, labelling index and histological type of human solid tumours

1973 • 160 citations

Growth rates of primary breast cancers

1979 • 152 citations

Kinetics of cell proliferation of an experimental tumor.

1967 • 145 citations

Surgical Resection and Adjunctive lmmunotherapy for Selected Patients with Multiple Pulmonary Metastases

1973 • 142 citations

Labeling Index as a Prognostic Marker in Non-Hodgkin's Lymphomas<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>, <xref ref-type="fn" rid="fn4">4</xref>

1981 • 139 citations

Growth rate and radiosensitivity of human tumours—I

1966 • 139 citations

Kinetic parameters and the course of the disease in breast cancer

1981 • 135 citations

The kinetics of tumour cell proliferation and radiotherapy

1971 • 130 citations

Synchronization and recruitment in acute leukemia

1971 • 129 citations

Inhibition of CFU entry into cycle by a bone marrow extract.

1977 • 120 citations

Kinetic Parameters of Bone Marrow Stem Cells Using In Vivo Suicide by Tritiated Thymidine or by Hydroxyurea

1973 • 120 citations

Advanced stage and early relapse of breast carcinomas associated with high thymidine labeling indices.

1979 • 118 citations

On a Law of Growth of Jensen's Rat Sarcoma

1932 • 115 citations

Prognostic significance of pretreatment proliferative activity in adult acute leukemia

1977 • 115 citations

Asymptomatic solitary pulmonary nodules. Host survival, tumor size, and growth rate.

1973 • 112 citations

REGULATION OF HAEMOPOIETIC STEM CELL TURNOVER IN PARTIALLY IRRADIATED MICE

1972 • 108 citations

Classification of patients with disseminated cancer of the breast

1969 • 108 citations

Smoking and Health Now

1971 • 107 citations

A stimulator of stem cell proliferation in regenerating bone marrow.

1977 • 105 citations

The cell cycle and its significance for cancer treatment

1975 • 104 citations

Expansion of the growth fraction in multiple myeloma with alkylating agents

1975 • 96 citations

Asymptomatic solitary pulmonary nodules

1973 • 95 citations

Dependence of response of a C3H mammary carcinoma to fractionated irradiation on fractionation number and intertreatment interval.

1977 • 87 citations

Tumor size dependency in the radiation response of the Lewis lung carcinoma.

1975 • 86 citations

Proliferative Activity of the Stem Cells in the Bone-marrow of Mice after Single and Multiple Irradiations (Total-or Partial-body Exposure)

1970 • 85 citations

Timed sequential therapy of human leukemia based upon the response of leukemic cells to humoral growth factors.

1977 • 85 citations

The radiosensitivity of malignant melanomas part II: Clinical studies

1981 • 85 citations

Growth rate and radiosensitivity of human tumours—II

1966 • 81 citations

Breast cancfr–-influence of growth rate on prognosis and treatment evaluation.A study based on mastectomy scar recurrences

1976 • 81 citations

A pathobiologic overview of metastasis.

1977 • 79 citations

Stimulating factors liberated by treated bone marrow: in vitro effect on CFU kinetics.

1976 • 79 citations

Emotional and Behavioural Disorders--II

1965 • 77 citations

Effects of single doses of radiation on lung metastases in man and experimental animals

1972 • 77 citations

Dependence of Response of a C3H Mammary Carcinoma to Fractionated Irradiation on Fractionation Number and Intertreatment Interval

1977 • 76 citations

Tumor Doubling Time and Survival of Men with Bronchogenic Carcinoma

1974 • 74 citations

Irradiation of the lungs as an adjuvant therapy in the treatment of osteosarcoma of the limbs

1978 • 69 citations

Long-term results of the E.O.R.T.C. randomized study of irradiation and vinblastine in clinical stages I and II of Hodgkin's disease

1979 • 66 citations

An evaluation of split-course irradiation for pelvic malignancies

1980 • 66 citations

A Quantitative Study of the Growth of the Walker Rat Tumor and the Flexner-Jobling Rat Carcinoma

1935 • 66 citations

The Influence of Delay on the Natural History and Prognosis of Breast Cancer

1965 • 65 citations

Growth of seventy-eight recurrent mammary cancers:Quantitative study

1968 • 65 citations

Correlation of cell kinetic and clinical response to chemotherapy in disseminated neuroblastoma.

1977 • 57 citations

Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis of acute lymphoblastic leukaemia of childhood

1980 • 57 citations

Autoregulation of ascites tumour growth by inhibition of the G-1 and the G-2 phase

1971 • 56 citations

The Proliferative Status And Clonogenic Capacity Of Tumour Cells In A Transplantable Rhabdomyosarcoma Of The Rat Before And After Irradiation With 800 Rad Of X‐Rays

1978 • 55 citations

CHANGES IN THE PROLIFERATION RATE OF MOUSE EPIDERMIS AFTER IRRADIATION: CONTINUOUS LABELLING STUDIES

1976 • 54 citations

Comparison of cell proliferation kinetics in human and experimental tumors: response to irradiation.

1976 • 53 citations

Growth rate versus prognosis in resected primary bronchogenic carcinomas

1973 • 52 citations

EFFECTS OF HYDROXYUREA ON THE KINETICS OF COLONY FORMING UNITS OF BONE MARROW IN THE MOUSE

1971 • 50 citations

Production of stem cell proliferation regulators by fractionated haemopoietic cell suspensions

1979 • 50 citations

Relationship between the growth rate of human metastases, survival and pathological type

1974 • 49 citations

Post-irradiation proliferation kinetics of a serially transplanted murine adenocarcinoma

1975 • 49 citations

Characteristic Species Dependent Growth Patterns of Mammalian Neoplasms

1978 • 44 citations

Differences in Inducing Activity for Human Bone Marrow Colonies in Normal Serum and Serum From Patients With Leukemia

1973 • 44 citations

A comparison of the effects of radiation on tumour growth delay and cell survival (The effect of oxygen)

1973 • 44 citations

Effect of chemotherapy on the labelling index of myeloma cells

1974 • 44 citations

Production of colony-stimulating factor by leukemic leukocytes

1976 • 43 citations

Change in Volume of Irradiated Human Metastases. Investigation of Repair of Sublethal Damage and Tumour Repopulation

1972 • 43 citations

The Relation of Radiosensitivity and Radiocurability to the Histology of Tumour Tissue

1948 • 41 citations

The cell proliferation kinetics of four experimental tumors after acute X-irradiation.

1971 • 41 citations

Radiation response of artificial pulmonary metastases of the EMT6 tumor

1976 • 39 citations

Relation between mammary cancer growth kinetics and the intervals between screenings

1979 • 38 citations

Clonogenic Capacity of Proliferating and Nonproliferating Cells of a Transplantable Rat Rhabdomyosarcoma in Relation to its Radiosensitivity

1973 • 38 citations

Stimulating Factors and Cell Recruitment In Murine Bone Marrow Stem Cells and Emt6 Tumours

1978 • 37 citations

A CRITICAL REVIEW OF THE USE OF VINCRISTINE (VCR) AS A TUMOUR CELL SYNCHRONIZING AGENT IN CANCER THERAPY

1980 • 37 citations

Perturbation of Cell Cycle of Human Leukaemic Myeloblasts in vivo by Cytosine Arabinoside

1973 • 35 citations

Cell Proliferation In Emt6 Tumors Treated With Single Doses of X‐Rays Or Hydroxyurea. I. Experimental Results

1978 • 35 citations

[Growth rate and natural history of breast cancer].

1975 • 34 citations

Biological Aspects of Radiation Protection

1971 • 33 citations

The determination of time-dose relationships from clinical data

1971 • 31 citations

Effects of radiations on bone marrow.

1979 • 30 citations

Actions of the haemopoietic stem cell proliferation inhibitor

1979 • 30 citations

Studies of the processes occurring between two fractions in experimental mouse tumors

1976 • 29 citations

Local control and reduced complications in split course irradiation of prostatic cancer

1981 • 28 citations

AN IN VIVO DOUBLE LABELLING STUDY OF THE SUBSEQUENT FATE OF CELLS ARRESTED IN METAPHASE BY VINCRISTINE IN THE JB‐1 MOUSE ASCITES TUMOUR

1980 • 28 citations

Abscopal Effect of Irradiation on Haemopoietic Stem Cells of Shielded Bone Marrow—Role of Migration

1976 • 28 citations

THE EFFECT OF PARTIAL BODY IRRADIATION ON HAEMOPOIETIC STEM CELL MIGRATION

1980 • 27 citations

Chalone-induced mitotic inhibition in the Hewitt keratinising epidermal carcinoma of the mouse

1971 • 27 citations

Changes in labeling indices of human tumors after irradiation

1980 • 27 citations

Response of EMT-6 Tumors to Single Fractions of X Rays and Cyclotron Neutrons: Evaluation and Comparison of Multiple Endpoints

1977 • 26 citations

Variations in the cell kinetics and the growth rate in an experimental tumour during natural growth and after irradiation

1973 • 25 citations

A TECHNIQUE FOR DETERMINING THE PROPORTION OF THE CLONOGENIC CELLS IN S PHASE IN EMT6 CELL CULTURES AND TUMORS

1976 • 25 citations

Effects of CFU-S inhibitors on murine bone marrow during Ara-C treatment—I. Effects on stem cells

1980 • 25 citations

Induction of serum stimulation and plasma cell proliferation during chemotherapy of multiple myeloma

1977 • 24 citations

New Frontiers in Mammary Pathology

1982 • 24 citations

CELL KINETICS OF IRRADIATED EXPERIMENTAL TUMORS: CELL TRANSITION FROM THE NON‐PROLIFERATING TO THE PROLIFERATING POOL

1980 • 24 citations

Biological Aspects of Radiation Protection

1972 • 22 citations

HYDROXYUREA EFFECTS IN THE C3H MOUSE II. MAMMARY TUMOR CELL KINETICS

1973 • 22 citations

Cell kinetics in leukemia. Correlation with clinical features and response to chemotherapy

1975 • 22 citations

[The radiosensitivity of malignant melanomas].

1966 • 21 citations

Evaluation of Screening Programs for the Early Diagnosis of Breast Cancer

1978 • 21 citations

Croissance des cellules d'un fibrosarcome experimemtal irradie chez la souris c3h.

1966 • 20 citations

Clinical assessment of growth-rate in human tumours

1968 • 20 citations

On the Correlation Between Malignancy and the Rate of Growth of Tar Warts in Mice

1934 • 20 citations

The influence of cell proliferation in tumours and normal tissues during fractionated radiotherapy

1971 • 19 citations

A study of relapse and course of 153 cases of Hodgkin's disease (clinical stages I and II) treated at the institute gustave-roussy from 1963 to 1970 with radiotherapy alone or with adjuvant monochemotherapy

1980 • 19 citations

Partial synchronization of three solid animal tumours by X-rays

1980 • 19 citations

Study of a CFUs stimulating factor liberated by bone marrow cells after total and partial body irradiation.

1980 • 18 citations

Cellularity and Deoxyribonucleic Acid Synthesis in Bone Marrow after Total- and Partial-Body Irradiation

1961 • 18 citations

Critical Survey of Experimental Data on in vivo Synchronization by Hydroxyurea

1975 • 18 citations

Response and recovery kinetics of a solid tumour after irradiation

1980 • 18 citations

A comparison of the effects of radiation on tumour growth delay and cell survival. The effect of radiation quality

1975 • 18 citations

Further studies on the self-limitation of growth of JB-1 ascites tumours

1973 • 17 citations

CELL PROLIFERATION IN EMT6 TUMOURS TREATED WITH SINGLE DOSES OF X‐RAYS OR HYDROXYUREA II. COMPUTER SIMULATIONS

1980 • 16 citations

[Data on the rate of growth of human tumors].

1968 • 15 citations

CELL KINETIC ALTERATIONS IN NORMAL AND NEOPLASTIC CELL POPULATIONS IN VITRO AND IN VIVO FOLLOWING VINCRISTINE*. A REPLY TO DR CAMPLEJOHN'S REVIEW ARTICLE^†

1980 • 15 citations

Solid tumor models for the assessment of different treatment modalities:XVI. Sequential combined modality (cyclophosphamide–radiation) therapy

1981 • 14 citations

Kinetically directed combination therapy with adriamycin and X-irradiation in a mammary tumor model

1981 • 14 citations

Radiation-induced synchronization of the Walker carcinoma in vivo

1975 • 13 citations

DYNAMIC HISTOLOGY OF A RAT HEPATOMA AND THE RESPONSE TO 5-FLUOROURACIL

1980 • 12 citations

New Frontiers in Mammary Pathology

1981 • 12 citations

GROWTH CURVES AND THEIR FUNCTIONAL FORM

1960 • 11 citations

Cell Kinetics in Leukemia

1975 • 10 citations

The Natural History of Human Breast Cancer

1981 • 10 citations

Cell kinetics and the management of malignant disease

1981 • 10 citations

The Influence of Tumor Growth Kinetics on the Response to Radiation Therapy and Drug Therapy in Man

2015 • 9 citations

RECYCLING OF RESTING CELLS IN THE JB‐1 ASCITES TUMOUR AFTER TREATMENT WITH 1‐β‐D‐ARABINOFURANOSYLCYTOSINE (Ara‐C)

1976 • 9 citations

Influence of factors derived from EMT6 tumors and from bone marrow of tumor-bearing mice on tumor and bone marrow stem cell kinetics.

1979 • 8 citations

[Growth rate of pulmonary metastases (author's transl)].

1979 • 7 citations

THE CELL POPULATION KINETICS AND RESPONSE TO AN S‐PHASE SPECIFIC AGENT OF THREE TRANSPLANTABLE COLON TUMOR LINES

1980 • 6 citations

S-phase fractions of breast carcinomas. Relationships to morphology, estrogen and progesterone receptors, and early recurrence.

1978 • 5 citations

Pilot studies of the cell population kinetics in irradiated tumours

1967 • 5 citations

Hematological Effects of Partial Body Irradiation: Clinical and Experimental Data

1971 • 4 citations

Minimal criteria for synchronization in clinical trials.

1981 • 4 citations

[Inhibitors of bone marrow stem cells proliferation. Possible applications during chemotherapy (author's transl)].

1981 • 2 citations