Tumour necrosis factor α induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor κB and activator protein-1

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

AP-1: a double-edged sword in tumorigenesis

2003 • 2,077 citations

Regulation of hepatic glutathione synthesis: current concepts and controversies

1999 • 858 citations

Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.

1975 • 729 citations

AP-1 in mouse development and tumorigenesis

2001 • 727 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2

1999 • 584 citations

Constitutive and β-Naphthoflavone-induced Expression of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene Is Regulated by a Distal Antioxidant Response Element/TRE Sequence

1997 • 442 citations

Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens.

1990 • 383 citations

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 368 citations

A Dominant Negative to Activation Protein-1 (AP1) That Abolishes DNA Binding and Inhibits Oncogenesis

1997 • 285 citations

An Electrophile Responsive Element (EpRE) Regulates β-Naphthoflavone Induction of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene

1998 • 260 citations

Up-Regulation of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene Involves Binding of Nrf-2 to an Electrophile Responsive Element

1999 • 238 citations

Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase.

1993 • 235 citations

Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits.

1984 • 213 citations

Amino acid sequence of rat kidney gamma-glutamylcysteine synthetase.

1990 • 171 citations

De novo synthesis of glutathione is required for both entry into and progression through the cell cycle

1995 • 167 citations

Tumor Necrosis Factor Increases Hepatocellular Glutathione by Transcriptional Regulation of the Heavy Subunit Chain of γ-Glutamylcysteine Synthetase

1997 • 145 citations

Long Exposure to High Glucose Concentration Impairs the Responsive Expression of γ-Glutamylcysteine Synthetase by Interleukin-1β and Tumor Necrosis Factor-α in Mouse Endothelial Cells

1996 • 136 citations

Differential regulation of γ-glutamylcysteine synthetase heavy and light subunit gene expression

1997 • 118 citations

Identification of a Variant Antioxidant Response Element in the Promoter of the Human Glutamate-Cysteine Ligase Modifier Subunit Gene

2002 • 109 citations

Regulation of human γ-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells

1997 • 108 citations

Glutamate–cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress

2002 • 106 citations

Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.

1992 • 95 citations

Expression of Glutathione and γ-Glutamylcysteine Synthetase mRNA Is Jun Dependent

1997 • 92 citations

Nuclear Factor Kappa B Dependent Induction of Gamma Glutamylcysteine Synthetase by Ionizing Radiation in T98G Human Glioblastoma Cells

1998 • 91 citations

Changes in glutathione homeostasis during liver regeneration in the rat

1998 • 88 citations

Induced expression of dominant-negative c-jun downregulates NF?B and AP-1 target genes and suppresses tumor phenotype in human keratinocytes

2000 • 81 citations

An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis

2002 • 71 citations

Inducers of γ-glutamylcysteine synthetase and their effects on glutathione synthetase expression

2000 • 69 citations

Loss of suppression of GSH synthesis at low cell density in primary cultures of rat hepatocytes

1992 • 68 citations

Effect of ethanol and high-fat feeding on hepatic ?-glutamylcysteine synthetase subunit expression in the rat

1999 • 64 citations

An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis

2002 • 63 citations

Hormonal and cell density regulation of hepatic gamma-glutamylcysteine synthetase gene expression.

1995 • 63 citations

Effect of Thioacetamide on the Hepatic Expression of γ-Glutamylcysteine Synthetase Subunits in the Rat

1999 • 54 citations

Induction of Human Methionine Adenosyltransferase 2A Expression by Tumor Necrosis Factor α

2003 • 53 citations

Cloning and characterization of the 5′-flanking region of the rat glutamate-cysteine ligase catalytic subunit

2001 • 50 citations

Role of AP-1 in the Coordinate Induction of Rat Glutamate-cysteine Ligase and Glutathione Synthetase bytert-Butylhydroquinone

2002 • 41 citations

Inducible expression of the γ-glutamylcysteine synthetase light subunit by t-butylhydroquinone in HepG2 cells is not dependent on an antioxidant- responsive element

1998 • 40 citations

Cloning and characterization of the 5′-flanking region of the rat glutamate-cysteine ligase catalytic subunit

2001 • 28 citations

Mechanism of action of a dominant negative c‐jun mutant in inhibiting activator protein‐1 activation

2002 • 25 citations