Brain Amino Acids During Hyponatremia In Vivo: Clinical Observations and Experimental Studies

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Osmotic Demyelination Syndrome Following Correction of Hyponatremia

1986 • 757 citations

Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures

1990 • 689 citations

NEUROLOGICAL MANIFESTATIONS AND MORBIDITY OF HYPONATREMIA: CORRELATION WITH BRAIN WATER AND ELECTROLYTES

1976 • 583 citations

Hyponatremia, Convulsions, Respiratory Arrest, and Permanent Brain Damage after Elective Surgery in Healthy Women

1986 • 573 citations

Rapid Correction of Hyponatremia Causes Demyelination: Relation to Central Pontine Myelinolysis

1981 • 320 citations

Central Pontine Myelinolysis

2002 • 302 citations

Epidemiology, Pathophysiology, and Management of Hyponatremic Encephalopathy

1997 • 290 citations

Study of brain electrolytes and organic osmolytes during correction of chronic hyponatremia. Implications for the pathogenesis of central pontine myelinolysis.

1991 • 274 citations

Volume regulation in astrocytes: A role for taurine as an osmoeffector

1988 • 260 citations

Central pontine myelinolysis following rapid correction of hyponatremia

1983 • 244 citations

Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats

1991 • 237 citations

Regional gamma-aminobutyric acid levels in rat brain determined after microwave fixation.

1975 • 235 citations

Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation

1988 • 216 citations

Osmolarity, ionic flux, and changes in brain excitability

1998 • 215 citations

Dissociation of Synchronization and Excitability in Furosemide Blockade of Epileptiform Activity

1995 • 202 citations

Treating hyponatremia: Damned if we do and damned if we don't

1990 • 189 citations

Does taurine act as an osmoregulatory substance in the rat brain?

1988 • 187 citations

HYPONATREMIA AND HYPERNATREMIA

1997 • 178 citations

Brain dehydration and neurologic deterioration after rapid correction of hyponatremia

1989 • 172 citations

Adaptation to chronic hypoosmolality in rats

1988 • 169 citations

FREE AMINO ACIDS AND RELATED COMPOUNDS IN DOG BRAIN: POST‐MORTEM AND ANOXIC CHANGES, EFFECTS OF AMMONIUM CHLORIDE INFUSION, AND LEVELS DURING SEIZURES INDUCED BY PICROTOXIN AND BY PENTYLENETETRAZOL*

1963 • 168 citations

Astrocytic Swelling Due to Hypotonic or High K⁺Medium Causes Inhibition of Glutamate and Aspartate Uptake and Increases Their Release

1995 • 161 citations

Swelling-activated Organic Osmolyte Channels

1997 • 155 citations

Changes in the Amino Acid Content of Nerve Endings (Synaptosomes) Induced by Drugs that Alter the Metabolism of Glutamate and γ‐Aminobutyric Acid

1984 • 131 citations

Taurine in Health and Disease

1994 • 129 citations

Hyponatraemic states following 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') ingestion

2002 • 121 citations

Hypotonic exposure enhances synaptic transmission and triggers spreading depression in rat hippocampal tissue slices

1995 • 121 citations

Volume regulatory loss of Na, Cl, and K from rat brain during acute hyponatremia

1987 • 120 citations

Seizure susceptibility and the osmotic state

1989 • 117 citations

Hyposmolarity-activated fluxes of taurine in astrocytes are mediated by diffusion

1991 • 106 citations

Regulatory volume decrease in cultured astrocytes. I. Potassium- and chloride-activated permeability

1994 • 103 citations

Inhibition of volume regulation and efflux of osmoregulatory amino acids by blockers of Cl− transport in cultured astrocytes

1993 • 101 citations

Volume regulation in brain cells: Cellular and molecular mechanisms

1996 • 98 citations

Regulatory volume decrease in cultured astrocytes. II. Permeability pathway to amino acids and polyols

1994 • 97 citations

Role of organic osmolytes in myelinolysis. A topographic study in rats after rapid correction of hyponatremia.

1995 • 94 citations

Osmotic effects upon excitability in rat neocortical slices

1990 • 89 citations

Organic osmolytes in acute hyponatremia

1993 • 88 citations

Role of taurine in osmoregulation in brain cells: Mechanisms and functional implications

1997 • 85 citations

Rapid correction of severe hyponatremia in the rat: histopathological changes in the brain

1985 • 84 citations

Rapid correction of hyponatremia produces differential effects on brain osmolyte and electrolyte reaccumulation in rats

1993 • 83 citations

Adaptive decreases in amino acids (taurine in particular), creatine, and electrolytes prevent cerebral edema in chronically hyponatremic mice: Rapid correction (experimental model of central pontine myelinolysis) causes dehydration and shrinkage of brain

1987 • 82 citations

Cell volume regulation in cultured cerebellar granule neurons

1993 • 68 citations

Taurine efflux and the regulation of cell volume in incubated slices of rat cerebral cortex

1994 • 67 citations

Effects of anion channel blockers on hyposmotically induced amino acid release from the in vivo rat cerebral cortex.

1999 • 62 citations

EFFECTS OF SALT AND WATER LOADING ON CARBOHYDRATE AND ENERGY METABOLISM AND LEVELS OF SELECTED AMINO ACIDS IN THE BRAINS OF YOUNG MICE¹

1975 • 53 citations

Symptomatic hyponatremia in rats: effect of treatment on mortality and brain lesions

1989 • 52 citations

Hyponatremia and hypernatremia

2000 • 46 citations

Brain amino acids decrease in chronic hyponatremia and rapid correction causes brain dehydration: Possible clinical significance

1987 • 45 citations

A new method for the determination of taurine in tissues

1960 • 45 citations

Effect of osmolality and anion channel inhibitors on myo-inositol efflux in cultured astrocytes

1999 • 38 citations

Response of tissues of the rat to anisosmolality in vivo

1993 • 37 citations

Properties of osmolyte fluxes activated during regulatory volume decrease in cultured cerebellar granule neurons

1994 • 36 citations

Swelling-activated amino acid efflux in the human neuroblastoma cell line CHP-100

1996 • 36 citations

Taurine levels, uptake and synthesizing enzyme activities in degenerated rat retinas

1979 • 23 citations

Osmotic Sensitivity of Taurine Release from Hippocampal Neuronal and Glial Cells

2002 • 23 citations

Correction of hyponatremia

2001 • 20 citations

Mechanisms of hypoosmotic volume regulation in glioma cells

1994 • 20 citations

Cell Volume Regulation in Taurine Deficient Cultured Astrocytes

1994 • 19 citations

Brain adaptation to acute hyponatremia in young rats

1999 • 17 citations