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Bronchial reactivity to inhaled histamine: a method and clinical survey

1977 • 1,884 citations

Mechanics of Airway Narrowing1–3

2015 • 501 citations

Analysis of Dose-Response Curves to Methacholine: An Approach Suitable for Population Studies

1987 • 484 citations

A Comparison of Bronchodilator Therapy with or without Inhaled Corticosteroid Therapy for Obstructive Airways Disease

1992 • 354 citations

The Normative Aging Study: An Interdisciplinary and Longitudinal Study of Health and Aging

1972 • 350 citations

Prevalence of bronchial hyperresponsiveness and asthma in a rural adult population.

1987 • 288 citations

The host factor in bronchitis

1961 • 254 citations

The Role of Allergy and Nonspecific Airway Hyperresponsiveness in the Pathogenesis of Chronic Obstructive Pulmonary Disease

1989 • 219 citations

Reference Values of the Provocative Concentrations of Methacholine that Cause 6% and 20% Changes in Forced Expiratory Volume in One Second in a Normal Population^1–3

1983 • 215 citations

The Relationship of Nonspecific Bronchial Responsiveness to the Occurrence of Respiratory Symptoms and Decreased Levels of Pulmonary Function

1987 • 175 citations

Bronchial reactivity to inhaled histamine and annual rate of decline in FEV1 in male smokers and ex-smokers.

1985 • 172 citations

Prevalence and nature of bronchial hyperresponsiveness in subjects with chronic obstructive pulmonary disease.

1985 • 161 citations

A Screening Test for Airways Reactivity

1982 • 148 citations

Bronchial hyperreactivity in chronic obstructive bronchitis.

1982 • 129 citations

Host Factors Affecting Longitudinal Decline in Lung Spirometry Among Grain Elevator Workers

1984 • 114 citations

The Relationship between Airway Responsiveness to Histamine and Pulmonary Function Level in a Random Population Sample

1988 • 114 citations

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1984 • 98 citations

The Relationship of Nonspecific Airway Responsiveness and Atopy to the Rate of Decline of Lung function: The Normative Aging Study

1990 • 80 citations

Measurement of bronchial reactivity: a question of interpretation.

1981 • 60 citations

Methacholine Responsiveness, Smoking, and Atopy as Risk Factors for Accelerated FEV₁Decline in Male Working Populations

1992 • 57 citations

Relation Between Bronchial Reactivity to Inhaled Histamine and Annual Decline in FEV 1 in Male Smokers and Exsmokers

1984 • 46 citations

Prognostic value of acetylcholine challenge test: a prospective study.

1984 • 40 citations

Histamine dose-response curves in asthma: relevance of the distinction between PC20 and reactivity in characterising clinical state.

1981 • 39 citations

The Influence of Age and Level of Pulmonary Function on Nonspecific Airway Responsiveness: The Normative Aging Study

1991 • 34 citations

The relevance of hyperresponsiveness but not of atopy to FEV1 decline. Preliminary results in a working population.

1987 • 34 citations

Inhibition of Methacholine-induced Bronchoconstriction in Patients with Chronic Obstructive Pulmonary Disease

1988 • 16 citations