Protection of atrial natriuretic factor against degradation: diuretic and natriuretic responses after in vivo inhibition of enkephalinase (EC 3.4.24.11) by acetorphan.

Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.

1986 • 711 citations

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

1978 • 652 citations

Atrial Natriuretic Hormone, the Renin–Aldosterone Axis, and Blood Pressure–Electrolyte Homeostasis

1985 • 517 citations

The hydrolysis of α-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11

1987 • 280 citations

Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues.

1984 • 263 citations

Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)

1988 • 207 citations

Binding of angiotensin and atrial natriuretic peptide in brain of hypertensive rats

1986 • 175 citations

Role of renal endopeptidase 24.11 in kinin metabolism in vitro and in vivo

1987 • 164 citations

Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney

1988 • 158 citations

Pharmacological properties of acetorphan, a parenterally active "enkephalinase" inhibitor.

1986 • 143 citations

Effects of alpha-human atrial natriuretic peptide in essential hypertension.

1985 • 123 citations

Distribution of enkephalinase (membrane metalloendopeptidase, E.C. 3.4.24.11) in rat organs. Detection using a monoclonal antibody.

1988 • 120 citations

Effect of Chronic Infusion of Synthetic Atrial Natriuretic Factor (ANF 8-33) in Conscious Two-Kidney, One-Clip Hypertensive Rats

1985 • 119 citations

Degradation of atrial natriuretic factor by kidney cortex membranes. Isolation and characterization of the primary proteolytic product.

1987 • 101 citations

Inactivation of atrial natriuretic factor by the renal brush border

1987 • 87 citations

Atriopeptin III kinetics and pharmacodynamics in normal and anephric rats.

1986 • 86 citations

Disappearance of atrial natriuretic factor from circulation in the rat

1986 • 81 citations

Atriopeptin turnover: quantitative relationship between in vivo changes in plasma levels and atrial content.

1986 • 71 citations

Atrial natriuretic factor receptors in rat kidney, adrenal gland, and brain: Autoradiographic localization and fluid balance dependent changes

1986 • 57 citations

Enantiomers of thiorphan and acetorphan: correlation between enkephalinase inhibition, protection of endogenous enkephalins and behavioral effects.

1987 • 36 citations

Clearance and early hydrolysis of atrial natriuretic factor in vivo. Structural analysis of cleavage sites and design of an analogue that inhibits hormone cleavage.

1988 • 33 citations

Enkephalinase and angiotensin converting enzyme activities in human venous and arterial plasma

1986 • 23 citations

Degradation of atrial natriuretic peptides by an enzyme in rat kidney resembling neutral endopeptidase 24.11

1988 • 19 citations

Binding and functional effects of atrial natriuretic factor in isolated rat kidney

1987 • 19 citations

Dynorphin A-(1–10) amide stimulates the release of atrial natriuretic polypeptide (ANP) from rat atrium

1987 • 19 citations

Evaluation of enkephalinase inhibition in the living mouse, using [3H]acetorphan as a probe.

1988 • 17 citations

Effects and Pharmacokinetics of Bolus Injections of Atrial Natriuretic Factor in Normal Volunteers

1988 • 13 citations

Atriopeptin 2 is hydrolysed by cardiac but not pulmonary isozyme of angiotensin-converting enzyme

1988 • 12 citations

Degradation of [125I]-atrial natriuretic peptide by a soluble metallopeptidase isolated from rat ventricular myocytes

1988 • 12 citations

Therapeutic actions of α-human atrial natriuretic polypeptide in 16 clinical cases

1987 • 10 citations

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