Modifiers of steroid-hormone metabolism: a review of their chemistry, biochemistry and clinical applications

Inhibition of Adrenal Corticosteroid Synthesis by Aminoglutethimide: Studies of the Mechanism of Action¹

1967 • 282 citations

Adrenal cortical carcinoma

1966 • 276 citations

Review: The Use of Isotopic Steroids for the Measurement of Production Rates in Vivo1

1963 • 275 citations

Verhandlungen der Naturforschenden Gesellschaft in Basel

2015 • 266 citations

Aminoglutethimide (Elipten-Ciba) as an Inhibitor of Adrenal Steroidogenesis: Mechanism of Action and Therapeutic Trial

1967 • 259 citations

16-Unsaturated C19 steroids a review of their chemistry, biochemistry and possible physiological role

1972 • 258 citations

ALTERATIONS OF ADRENAL STEROID PATTERNS IN MAN RESULTING FROM TREATMENT WITH A CHEMICAL INHIBITOR OF 11 βHYDROXYLATION

1958 • 244 citations

Effect of an Adrenal Inhibitor in Hypertensive Patients With Suppressed Renin

1969 • 194 citations

Biological hydroxylation mechanisms

1973 • 186 citations

Steroidogenesis and cell structure

1973 • 162 citations

Effects of Amino-glutethimide on Adrenal Function in Man¹

1967 • 154 citations

PROGRESS IN ENDOCRINOLOGY

1938 • 146 citations

New Amphenone analogs as adrenocortical inhibitors

1958 • 131 citations

Cleavage of Cholesterol Side Chain by Adrenal Cortex

1961 • 130 citations

An Effect of o,p′-DDD on the Extra-adrenal Metabolism of Cortisol in Man

1964 • 112 citations

Preliminary trial of aminoglutethimide in breast cancer

1973 • 110 citations

Inhibitors of Adrenal Steroid Biosynthesis

1970 • 105 citations

A TEST OF PITUITARY RESERVE UTILIZING INTRAVENOUS SU-4885, WITH A NEW METHOD FOR EXTRACTION OF 11-DESOXYCORTICOSTEROIDS

1960 • 97 citations

Über die adrenale Steroid‐Biosynthese in vitro. III. Selektive Hemmung der Nebennierenrinden‐Funktion

1966 • 96 citations

Inhibition of Steroidogenesis at Various Sites in the Biosynthetic Pathway in Relation to Induced Ovulation

1971 • 93 citations

Aminoglutethimide: a ‘side-effect’ turned to therapeutic advantage

1970 • 90 citations

EFFECTS OF o,p' DDD¹ON HISTOLOGY AND 17- HYDROXYCORTICOSTEROID OUTPUT OF THE DOG ADRENAL CORTEX¹

1959 • 73 citations

Treatment of Cushing's Disease

1969 • 70 citations

TESTICULAR CYTOCHROME P-450 AND IRON-SULFUR PROTEIN AS RELATED TO STEROID METABOLISM

1973 • 67 citations

Studies on Aldosterone Biosynthesis in Vitro^*

1966 • 66 citations

INHIBITION OF ALDOSTERONE SECRETION AND MODIFICATION OF ELECTROLYTE EXCRETION IN MAN BY A CHEMICAL INHIBITOR OF 11β-HYDROXYLATION*†

1959 • 65 citations

The metabolism of glutethimide (Doriden®)

1962 • 64 citations

Adrenal Cells in Tissue Culture. IV. Use of an Inhibitor of Steroid Synthesis for the Study of ACTH Action

1969 • 62 citations

A CRITICAL APPRAISAL OF A METHOD OF ESTIMATING URINARY 17-OXOSTEROIDS AND TOTAL 17-OXOGENIC STEROIDS

1969 • 60 citations

Memoirs of the Society for Endocrinology

1953 • 59 citations

On the specific inhibition of adrenal steroid biosynthesis

1962 • 59 citations

A NEW FLUORIMETRIC METHOD OF PLASMA CORTISOL ASSAY WITH A STUDY OF PITUITARY—ADRENAL FUNCTION USING METYRAPONE (SU. 4885)

1963 • 58 citations

Inhibition of Adrenal Steroidogenesis by Amino-Glutethimide and the Mechanism of Action

1967 • 58 citations

THE INHIBITION OF STEROIDOGENESIS BY AMPHENONE B: STUDIES IN VITRO WITH THE PERFUSED CALF ADRENAL

1956 • 57 citations

Amino-Glutethimide and Metastatic Adrenal Cancer

1966 • 54 citations

Effects of Aminoglutethimide Upon Adrenal Function and Cortisol Metabolism in Cushing's Syndrome

1967 • 53 citations

AMPHENONE: TOXICITY AND EFFECTS ON ADRENAL AND THYROID FUNCTION IN MAN

1956 • 52 citations

Plasma Metyrapone, Adrenocorticotropic Hormone, Cortisol, and Deoxycortisol Levels

1970 • 50 citations

Inhibition studies on the aromatization of androst-4-ene-3,17-dione by human placental microsomal preparations

1972 • 50 citations

A COMPARISON OF THE INHIBITORY EFFECTS OF 2-METHYL-l,2-BIS(3-PYRIDYL)-l-PROPANONE AND AMPHENONE B ON ADRENAL CORTICAL SECRETION IN THE DOG¹

1959 • 49 citations

THE CHEMICAL FRACTIONATION OF AN ADRENOCORTICOLYTIC DRUG¹²³

1958 • 46 citations

Efficacy of Amino-Glutethimide in the Ectopic ACTH Syndrome

1968 • 45 citations

STUDIES WITH AN ADRENAL INHIBITOR IN ADRENAL CARCINOMA*

1960 • 44 citations

Control of ovarian cholesterol ester biosynthesis

1973 • 43 citations

Transformation of labeled cholesterol, 20α-hydroxycholesterol, (22R)-22-hydroxycholesterol, and (22R)-20α, 22-dihydroxycholesterol by adrenal acetone-dried preparations from Guinea pigs, cattle and man: II. Kinetic studies

1970 • 41 citations

An Effect of Adrenocorticotrophic Hormone on Adrenal Cholesterol Accumulation

1967 • 40 citations

Gas chromatographic separation of steroids on glass capillary columns

1970 • 40 citations

Plasma 11-Deoxycorticosteroid and ACTH Response to Metyrapone (Plasma Metyrapone Test)

1969 • 40 citations

Pharmacologic alteration of steroid hormone functions

1968 • 38 citations

The acute action of adrenocorticotropic hormone on adrenal steroidogenesis

1974 • 38 citations

Inhibitors of Adrenal Corticosteroid 17α-Hydroxylation

1962 • 37 citations

Chemistry and Structure-Activity Relationships of Amphenone Analogues

1959 • 37 citations

On the biosynthesis of testicular steroids in vitro and its inhibition

1965 • 34 citations

Ultrastructural Alterations Produced in Rat Adrenal by Aminoglutethimide. A Stereologic and Cytochemical Study

1972 • 32 citations

DETERMINATION OF THE 11β-HYDROXYLASE ACTIVITY IN MICROGRAM SAMPLES OF TISSUE; ITS QUANTITATIVE HISTOLOGICAL DISTRIBUTION IN THE RAT ADRENAL, AND THE INFLUENCE OF CORTICOTROPHIN

1966 • 31 citations

Antithyroid and Antiadrenocortical Activity of Aminoglutethimide

1966 • 30 citations

Inhibition of α- and β-Hydroxysteroid Dehydrogenases and Steroid Δ-Isomerase by Substrate Analogues¹

1968 • 30 citations

Modification of Aldosterone Secretion and Electrolyte Excretion in Man by a Chemical Inhibitor of 18-Oxidation

1964 • 29 citations

A Peripheral Action of o,p′-DDD on Steroid Biotransformation

1963 • 29 citations

FURTHER OBSERVATIONS ON THE FUNCTIONAL ZONATION OF THE ADRENAL CORTEX

1964 • 29 citations

Suppression of tumorous adrenal hyperfunction by aminoglutethimide

1967 • 28 citations

The urinary excretion of aminoglutethimide in man

1965 • 28 citations

THE BIOSYNTHESIS OF ADRENOCORTICAL STEROIDS

1968 • 28 citations

METOPIRONE DOSAGE IN PITUITARY FUNCTION TEST

1962 • 28 citations

Influence of metopirone on substrate-supported hydroxylation of DOC by rat adrenal mitochondria

1966 • 27 citations

A stereologic study of the effects of metopiron on the rat adrenal.

1969 • 26 citations

The reduction of SU-4885 by adrenal glands and other tissues and its inhibition by ACTH

1968 • 26 citations

Studies on enzyme reactions related to steroid biosynthesis

1970 • 26 citations

INHIBITION OF '19-HYDROXYLASE' ACTIVITY IN THE GOLDEN HAMSTER ADRENAL BY SU4885

1963 • 25 citations

Influence of an Inhibitor of 17α-Hydroxylation on the Biosynthesis of Testosterone by Testicular Tissue

1963 • 24 citations

The effect of ortho, para'DDD on steroid hormone metabolites in adrenocortical carcinoma.

1962 • 23 citations

Androgen biosynthesis I. Enzymatic cleavage of the cholesterol side-chain to dehydroepiandrosterone and 2-methylheptan-6-one

1968 • 23 citations

Chemical Studies on Pinacols Obtained from p-Aminoacetophenone and p-Aminopropiophenone¹

1950 • 22 citations

The effect of 2, 2-Bis (2-chlorophenyl-4-chlorophenyl)-1, 1-dighloroethane (o, p'-DDD) on the metabolism of infused cortisol-7-3H

1966 • 22 citations

Separation and identification of urinary steroids on glass capillary columns in a combination of gas chromatograph and mass spectrometer

1970 • 22 citations

Lipoide Transformation der Mitochondrien in Nebennierenrindenzellen nach Aminoglutäthimid (Elipten® Ciba)

1970 • 22 citations

ADRENOCORTICAL CARCINOMA IN MAN. THE EFFECT OF AMPHENONE ON INDIVIDUAL KETOSTEROIDS*

1958 • 22 citations

Production of Congenital Lipoid Adrenal Hyperplasia in Rats and Inhibition of Cholesterol Side-Chain Cleavage

1970 • 22 citations

ENDOCRINE EFFECTS OF METHYLENEDIANILINE IN THE RAT, RABBIT AND DOG

1960 • 21 citations

The Metopirone test of pituitary corticotrophin release

1968 • 20 citations

Qualitative Alterations in Urinary 17-Ketosteroid Excretion During Aminoglutethimide Administration

1969 • 20 citations

Effect of inhibitors on testicular microsomal steroid 17α-hydroxylase and 17α-hydroxypregnene C17–C20 lyase

1965 • 19 citations

EFFECT OF PARTIAL ADRENAL CORTICAL ATROPHY ON THE COURSE OF ALLOXAN DIABETES*

1952 • 19 citations

Inhibition of Adrenal Corticosteroidogenesis in the Rat by Cyanotrimethylandrostenolone, a Synthetic Androstane

1966 • 19 citations

THE IDENTIFICATION OF STEROIDS

1970 • 18 citations

THE EFFECT OF METYRAPONE ON CORTICOTROPHIN SECRETION

1972 • 16 citations

Evidence suggesting 11 β-hydroxylase inhibition during aminoglutethimide administration

1971 • 16 citations

A dissociated effect of Amino-Glutethimide on the mineralocorticoid secretion in man

1973 • 16 citations

Enzymatic cleavage of the cholesterol side chain to dehydroepiandrosterone and 2-methylheptan-6-one

1968 • 16 citations

Experimental Congenital Adrenocortical Hyperplasia: Persistent Postnatal Deficiency in Activity of 3β-Hydroxysteroid Dehydrogenase Producedin Utero

1967 • 16 citations

Effects of ACTH and Cyclic-AMPin Vitroon Incorporation of³H-leucine and¹⁴C-orotic Acid Into Protein and RNA in the Presence of an Inhibitor of Cholesterol Side Chain Cleavage

1969 • 15 citations

Clinical and chemical response of functioning adrenal cortical carcinoma to ortho, para'-DDD.

1962 • 15 citations

Inhibition of cholesterol side-chain cleavage by azacholesterols

1971 • 15 citations

Experimental Congenital Lipoid Adrenal Hyperplasia: Prevention of Anatomic Defects Produced by Aminoglutethimide

1970 • 14 citations

Ovarian Dysfunction Associated With an Anticonvulsant Drug

1969 • 14 citations

EFFECTS OF AMPHENONE B ON THE ENZYMATIC PROPERTIES OF TESTICULAR MICROSOMES

1958 • 13 citations

Plasma and Urinary 11-Desoxycorticosteroid (11-DOCS) Response to Metyrapone in Pituitary, Renal and Hepatic Disease

1967 • 13 citations

Aminoglutethimide: A Possible Cause of Pseudohermaphroditism in Females

1972 • 13 citations

Effect of aminoglutethimide on extraglandular metabolism of exogenous testosterone

1971 • 12 citations

[Clinical and biological study of an inhibitor of adrenocortical hormone synthesis: aminoglutethinide].

1968 • 12 citations

Failure of Metyrapone To Inhibit 11-Hydroxylation of 11-Deoxycortisol During Drug Therapy¹

1967 • 12 citations

Hypertrophie des glatten endoplasmatischen Reticulum in Nebennierenrinden-Zellen nach Aminoglutäthimid

1971 • 12 citations

Further Studies on the Properties of the Enzyme System Involved in the Conversion of C21 Steroids into 16-Unsaturated C19 Steroids in Boar Testis

1973 • 12 citations

THE CONVERSION IN VITRO OF PREGNENOLONE TO C19 AND C21 METABOLITES BY THE RAT ADRENAL GLAND, WITH AND WITHOUT METYRAPONE

1972 • 12 citations

Inhibitionin Vitroof Adrenal Pregnenolone Biosynthesis by Amphenone and Its Analogues

1964 • 11 citations

MODIFIERS OF ADRENOCORTICAL FUNCTION

1965 • 10 citations

Electron microscopic studies on the adrenal of rat treated with aminoglutethimide--with special reference to accumulation of cholesterol in intramitochondrial vacuoles.

1971 • 9 citations

Inhibition of 16α-hydroxylation in human testis tissue by SU-9055

1966 • 9 citations

Effect of aminoglutethimide on urinary steroid excretion in patients with congenital adrenal hyperplasia due to incomplete 21-hydroxylase deficiency

1972 • 9 citations

The Treatment of Congenital Adrenal Hyperplasia with Aminoglutethimide

1970 • 9 citations

EFFECT OF SU 4885 ON URINARY OESTROGENS

1964 • 8 citations

Steroid-Mediated Stimulation of Aerobic Glycolysis by Intact Mouse Adrenal Glandsin Vitro

1971 • 8 citations

EFFECTS OF O,p″DDD AND AMINOGLUTETH–IMIDE ON METASTATIC ADRENOCORTICAL CARCINOMA

1969 • 8 citations

Studies of adrenal cortical suppression by amphenone in patients with secondary hyperaldosteronism

1958 • 8 citations

Effect of<scp>dl</scp>-2(p-Aminophenyl)-2-phenylethylamine on Adrenocortical Function in Cushing's Syndrome Due to Nontumorous Adrenocortical Hyperfunction¹

1967 • 8 citations

Effect of SK&amp;F-12185 [dl-2(p-Aminophenyl)-2-phenylethylamine] on Adrenocortical Function in Primary Aldosteronism

1967 • 7 citations

Activities of Various Steroidogenic Enzymes in Two Forms of Experimental Adrenal Hyperplasia

1967 • 7 citations

The treatment of secondary hyperaldosteronism with oedema by amino-glutethimide

1970 • 7 citations

Maternal and Fetal Effects of Two Inhibitors of 3β-Hydroxysteroid Dehydrogenase and Δ^5–4,3-Ketosteroid Isomerase in the Rat

1969 • 7 citations

Adrenal inhibition in the rat and guinea pig by 2-(p-aminophenyl)-2-phenylethylamine (SK&amp;F 12185)

1966 • 7 citations

Aminoglutethimide in Functioning Adrenal Carcinoma

1969 • 6 citations

Effect of ACTH and Aminoglutethimide on Cholesterol Metabolism in Sheep Adrenal Cortex in Vitro12

1972 • 6 citations

Ovarian Physiology

1966 • 6 citations

URINARY OESTROGEN EXCRETION AFTER METYRAPONE ADMINISTRATION TO PATIENTS WITH THE POLYCYSTIC OVARY SYNDROME

1967 • 5 citations

Effects of 2-methyl-1,2-bis(3'-pyridyl)-1-propanol (reduced metopirone) on the formation of 18-hydroxylated steroids by quartered rat adrenals

1969 • 5 citations

Lack of Glutethimide Effect on Adrenal

1967 • 4 citations

Etude de la 21-hydroxylase des glandes surrenales du canard domestique (Anas platyrhynchos)

1972 • 4 citations

The effect of d-2(p-aminophenyl)-2-phenylethylamine (SK&amp;F-12185) in Cushing's syndrome associated with adrenocortical carcinoma

1968 • 3 citations

Complement metabolism in membranoproliferative nephritis.

1971 • 2 citations

EFFECT OF METYRAPONE ON THE OESTROGEN-LIKE EFFECT OF DEHYDROEPIANDROSTERONE

1972 • 1 citations