Angiotensin II receptor pharmacology and AT1-receptor blockers

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Angiotensin II receptors and angiotensin II receptor antagonists.

1993 • 1,843 citations

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.

1995 • 918 citations

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart.

1990 • 878 citations

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1995 • 858 citations

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

1993 • 767 citations

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

1995 • 740 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

1993 • 713 citations

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

1995 • 688 citations

Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors.

1995 • 642 citations

Angiotensin II-forming pathways in normal and failing human hearts.

1990 • 585 citations

Expression of AT2 receptors in the developing rat fetus.

1991 • 537 citations

Nonpeptide angiotensin II receptor antagonists

1991 • 522 citations

Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat.

1994 • 421 citations

Angiotensin II Induces c-fos mRNA in Aortic Smooth Muscle

1989 • 401 citations

Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors

1992 • 367 citations

Angiotensin II receptor blockade limits glomerular injury in rats with reduced renal mass.

1992 • 352 citations

Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain

1991 • 342 citations

Nonpeptide angiotensin II receptor antagonists. XI. Pharmacology of EXP3174: an active metabolite of DuP 753, an orally active antihypertensive agent.

1990 • 324 citations

Angiotensin II type-1 receptor subtype cDNAs: Differential tissue expression and hormonal regulation

1992 • 317 citations

Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent.

1990 • 314 citations

Role of the Pressor Action of Angiotensin IIin Experimental Hypertension

1971 • 297 citations

Opposing Actions of Angiotensin II on Microvascular Growth and Arterial Blood Pressure

1996 • 287 citations

Cloning and expression of a novel angiotensin II receptor subtype.

1992 • 270 citations

Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans

1995 • 266 citations

Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT₁‐receptor subtype

1993 • 254 citations

The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase

1992 • 252 citations

Losartan Potassium

1996 • 249 citations

Angiotensin II Receptor Subtypes

1992 • 230 citations

Role of Janus Kinase/Signal Transducer and Activator of Transcription and Mitogen-activated Protein Kinase Cascades in Angiotensin II- and Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Proliferation

1997 • 226 citations

Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor

1997 • 218 citations

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).

1993 • 211 citations

Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells.

1994 • 204 citations

Nonpeptide angiotensin II receptor antagonists. IX. Antihypertensive activity in rats of DuP 753, an orally active antihypertensive agent.

1990 • 203 citations

Evidence for the role of phosphorylase kinase, protein kinase C, and other Ca2+-sensitive protein kinases in the response of hepatocytes to angiotensin II and vasopressin.

1984 • 192 citations

Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta.

1992 • 188 citations

Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.

1994 • 182 citations

Pilot study of the uricosuric effect of DuP-753, a new angiotensin II receptor antagonist, in healthy subjects

1992 • 174 citations

Angiotensin II Activates pp60 ^{c- src} in Vascular Smooth Muscle Cells

1995 • 167 citations

Role of Angiotensin II in Activation of the JAK/STAT Pathway Induced by Acute Pressure Overload in the Rat Heart

1997 • 152 citations

Cloning and characterization of a human angiotensin II type 1 receptor

1992 • 152 citations

Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein

1994 • 147 citations

Angiotensin II induces expression of the - gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells

1988 • 146 citations

Differential gene expression and regulation of type-1 angiotensin II receptor subtypes in the rat

1992 • 146 citations

Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans.

1993 • 146 citations

Inhibition of rabbit aortic angiotensin II (AII) receptor by CV-11974, a new nonpeptide AII antagonist

1993 • 143 citations

Candesartan (CV-11974) dissociates slowly from the angiotensin AT1 receptor

1997 • 139 citations

Angiotensin II AT2 receptors do not interact with guanine nucleotide binding proteins

1991 • 137 citations

Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin

1993 • 133 citations

The angiotensin AT₂ receptor modulates T‐type calcium current in non‐differentiated NG108‐15 cells

1992 • 130 citations

Valsartan: Preclinical and Clinical Profile of an Antihypertensive Angiotensin‐II Antagonist

1995 • 130 citations

The Type I Angiotensin II Receptor Couples to Stat1 and Stat3 Activation Through Jak2 Kinase in Neonatal Rat Cardiac Myocytes

1997 • 122 citations

Differential expression of angiotensin II receptor subtype mRNAs (AT-1A and AT-1B) in the brain

1992 • 122 citations

Binding of valsartan to mammalian angiotensin AT1 receptors

1995 • 115 citations

Distribution of angiotensin II receptor subtypes in rat brain nuclei

1991 • 109 citations

Heterogeneity of angiotensin synthetic pathways and receptor subtypes: physiological and pharmacological implications.

1993 • 102 citations

Characterization of the Angiotensin II Receptor Antagonist TCV-116 in Healthy Volunteers

1995 • 95 citations

Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566.

1992 • 95 citations

Cardiac and Vascular Effects of Long-term Losartan Treatment in Stroke-Prone Spontaneously Hypertensive Rats

1996 • 92 citations

Angiotensin-Converting Enzyme Inhibition in Infarct-Induced Heart Failure in Rats: Bradykinin Versus Angiotensin II

1994 • 91 citations

Molecular structure and transcriptional function of the rat vascular AT1a angiotensin receptor gene.

1993 • 89 citations

Novel Subtype of Human Angiotensin II Type 1 Receptor: cDNA Cloning and Expression

1994 • 88 citations

The Genomic Organization of Human Angiotensin II Type 1 Receptor

1994 • 77 citations

Angiotensin II receptor blockade with single doses of valsartan in healthy, normotensive subjects

1994 • 74 citations

Pharmacokinetics and Pharmacodynamics of Irbesartan in Healthy Subjects

1998 • 73 citations

Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.

1995 • 68 citations

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids

1993 • 62 citations

Pressor response to 1-sar-8-ala-angiotensin II (saralasin) in hypertensive subjects.

1977 • 62 citations

The genomic organization of the rat AT1 angiotensin receptor

1992 • 58 citations

Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues.

1994 • 58 citations

Angiotensin II stimulates protein tyrosine phosphatase activity through a G-protein independent mechanism.

1994 • 56 citations

The pharmacokinetics of losartan in renal insufficiency

1995 • 56 citations

Regulatory elements that mediate expression of the gene for the angiotensin II type 1a receptor for the rat.

1993 • 53 citations

The genomic organization of the rat angiotensin II receptor AT1B

1994 • 52 citations

A human neutrophil-dependent pathway for generation of angiotensin II. Purification of the product and identification as angiotensin II.

1981 • 50 citations

Expression, Genomic Organization, and Transcription of the Mouse Angiotensin II Type 2 Receptor Gene

1995 • 48 citations

Molecular Cloning of the Human Angiotensin II Type 2 Receptor cDNA

1994 • 45 citations

Human neutrophils release serine proteases capable of activating prorenin.

1987 • 45 citations

Comparison of the effects of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade on the evolution of spontaneous glomerular injury in male MWF/Ztm rats.

1996 • 44 citations

TCV‐116: A New Angiotensin II Type‐1 Receptor Antagonist

1994 • 35 citations

Identification of a Fourth Angiotensin AT1 Receptor Subtype in Rat

1993 • 24 citations

Linkage Mapping of the Angiotensin AT2Receptor Gene (Agtr2) to the Mouse X Chromosome

1995 • 18 citations

Effects of the AT1-selective angiotensin II antagonist, telmisartan, on hemodynamics and ventricular function after cardiopulmonary resuscitation in pigs

1997 • 18 citations

The effects of angiotensin II receptor blockade with losartan on systemic blood pressure and renal and extrarenal prostaglandin synthesis in women with essential hypertension*

1995 • 13 citations

Proceedings of the Symposium ‘Angiotensin AT₁ Receptors: From Molecular Physiology to Therapeutics’: HUMAN TYPE‐1 ANGIOTENSIN II (AT₁) RECEPTOR GENE STRUCTURE AND FUNCTION

1996 • 11 citations

Pressor response to angiotensin II in sodium replete normal subjects and its blockade by the angiotensin II (AII) antagonist SR 47436 (BMS 186295)

1995 • 10 citations