Evaluating HER2 amplification and overexpression in breast cancer

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS

1996 • 8,991 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

The HER‐2/ neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy

1998 • 973 citations

HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas.

1997 • 811 citations

erbB-2 and Response to Doxorubicin in Patients With Axillary Lymph Node-Positive, Hormone Receptor- Negative Breast Cancer

1998 • 667 citations

erbB-2, p53, and Efficacy of Adjuvant Therapy in Lymph Node-Positive Breast Cancer

1998 • 628 citations

Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.

1996 • 564 citations

Sensitivity of HER-2/neu antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression.

1994 • 495 citations

ERBB2 oncogene in human breast cancer and its clinical significance

1998 • 457 citations

Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer

1999 • 440 citations

neu/erbB-2 amplification identifies a poor-prognosis group of women with node-negative breast cancer. Toronto Breast Cancer Study Group.

1998 • 435 citations

c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases.

1996 • 423 citations

Human squamous cell lung cancers express increased epidermal growth factor receptors.

1984 • 371 citations

HER-2/neu Analysis in Archival Tissue Samples of Human Breast Cancer: Comparison of Immunohistochemistry and Fluorescence In Situ Hybridization

2001 • 333 citations

Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer.

2000 • 319 citations

Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group.

1999 • 296 citations

A scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group.

1997 • 198 citations

Amplification and over-expression of c-erbB-2 in transitional cell carcinoma of the urinary bladder

1991 • 177 citations

Recommendations for HER2 testing in the UK

2000 • 142 citations

Immunohistochemical detection ofHER2/neu in patients with axillary lymph node negative breast carcinoma. A study of epidemiologic risk factors, histologic features, and prognosis

1995 • 104 citations

The role of immunohistochemistry and fluorescence in situ hybridization for HER2/neu in assessing the prognosis of breast cancer.

1999 • 99 citations

Prognostic and predictive relevance of c-erbB-2 and ras expression in node positive and negative breast cancer.

1994 • 93 citations

Immunohistochemical determination of estrogen and progesterone receptors in human breast carcinoma. Correlation with histopathology and dna flow cytometry

1990 • 88 citations

Quantitative estimation of epidermal growth factor receptor and c-erbB-2 in human breast cancer.

1996 • 84 citations

Expression and amplification of the HER-2/ neu (c-erbB-2) protooncogene in epithelial ovarian tumors and cell lines

1991 • 68 citations

Fluorescence in situ hybridization (FISH) for detection of HER-2/neu amplification in breast cancer: a multicenter portability study.

2000 • 61 citations

Is chromosome 9 loss a marker of disease recurrence in transitional cell carcinoma of the urinary bladder?

1998 • 55 citations

Aneusomy of chromosomes 7 and 17 predicts the recurrence of transitional cell carcinoma of the urinary bladder

2000 • 43 citations

c-erbB-2 oncoprotein detected by automated quantitative immunocytochemistry in breast carcinomas correlates with patients' overall and disease-free survival

1997 • 38 citations

Estrogen receptors in 699 primary breast cancers: A comparison of immunohistochemical and biochemical methods

1995 • 35 citations

Amplification of HER-2/neu gene in human gastric adenocarcinomas: correlation with primary site

1995 • 22 citations

Chromosomal aberrations in transitional cell carcinoma that are predictive of disease outcome are independent of polyploidy

1999 • 20 citations

Quantitative radioimmunohistochemical measurements of p185(erbB-2) in frozen tissue sections.

1996 • 17 citations

Localization of EGF receptors in frozen tissue sections by antibody and biotinylated EGF-based techniques.

1994 • 14 citations

p185 overexpression in 220 samples of breast cancer undergoing primary surgery: comparison with c-erbB-2 gene amplification.

1998 • 10 citations