The past, present, and future of renal xenotransplantation

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: a major obstacle for xenotransplantation in humans

1993 • 645 citations

The generation of transgenic pigs as potential organ donors for humans

1995 • 598 citations

P-selectin induces the expression of tissue factor on monocytes.

1994 • 595 citations

IMMUNOPATHOLOGY OF HYPERACUTE XENOGRAFT REJECTION IN A SWINE-TO-PRIMATE MODEL

1991 • 459 citations

Human natural anti-alpha-galactosyl IgG. II. The specific recognition of alpha (1----3)-linked galactose residues.

1985 • 417 citations

Renal Heterotransplmtation in Man

1964 • 318 citations

THE ??-1,3-GALACTOSYLTRANSFERASE KNOCKOUT MOUSE

1996 • 306 citations

Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester.

1994 • 277 citations

Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection.

1990 • 274 citations

Barriers to xenotransplantation

1995 • 271 citations

INHIBITION OF COMPLEMENT-MEDIATED ENDOTHELIAL CELL CYTOTOXICITY BY DECAY-ACCELERATING FACTOR

1991 • 267 citations

Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection.

1994 • 264 citations

Organ transplantation between widely disparate species.

1970 • 242 citations

RENAL HETEROTRANSPLANTATION FROM BABOON TO MAN

1964 • 230 citations

Transient perturbation of endothelial integrity induced by natural antibodies and complement.

1995 • 227 citations

ACTIVATION OF INTRAGRAFT ENDOTHELIAL AND MONONUCLEAR CELLS DURING DISCORDANT XENOGRAFT REJECTION

1994 • 223 citations

Endothelial Cell Activation and Thromboregulation during Xenograft Rejection

1994 • 210 citations

Glucocorticoid-mediated Repression of NFκB Activity in Endothelial Cells Does Not Involve Induction of IκBα Synthesis

1996 • 204 citations

Evolution and pathophysiology of the human natural anti-?-galactosyl IgG (anti-Gal) antibody

1993 • 197 citations

Transplantation of Tissues

1959 • 185 citations

DIRECT ACTIVATION OF PORCINE ENDOTHELIAL CELLS BY HUMAN NATURAL KILLER CELLS1

1996 • 148 citations

T CELL INDEPENDENCE OF MACROPHAGE AND NATURAL KILLER CELL INFILTRATION, CYTOKINE PRODUCTION, AND ENDOTHELIAL ACTIVATION DURING DELAYED XENOGRAFT REJECTION1,2,3

1996 • 147 citations

Removal Of Baboon And Human Antiporcine Igg And Igm Natural Antibodies By Immunoadsorption

1995 • 131 citations

The role of C5a and antibody in the release of heparan sulfate from endothelial cells

1991 • 130 citations

A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes.

1996 • 75 citations

Transplantation of tissues

1959 • 73 citations

HUMAN NATURAL KILLER CELLS INDUCE MORPHOLOGIC CHANGES IN PORCINE ENDOTHELIAL CELL MONOLAYERS1

1996 • 71 citations

INHIBITION OF PLATELET INTEGRIN GPIIbIIIa PROLONGS SURVIVAL OF DISCORDANT CARDIAC XENOGRAFTS1,2

1996 • 71 citations

Baboon Renal Grafts

1964 • 68 citations

Beyond Hyperacute Rejection

1995 • 64 citations

EFFECT OF REPETITIVE HIGH-DOSE TREATMENT WITH SOLUBLE COMPLEMENT RECEPTOR TYPE 1 AND COBRA VENOM FACTOR ON DISCORDANT XENOGRAFT SURVIVAL1,2

1996 • 61 citations

Rapamycin inhibits production of cytotoxic but not noncytotoxic antibodies and preferentially activates T helper 2 cells that mediate long-term survival of heart allografts in rats.

1994 • 61 citations

THROMBIN INHIBITION IN AN EX VIVO MODEL OF PORCINE HEART XENOGRAFT HYPERACUTE REJECTION1

1996 • 53 citations

Tolerance and xenograft survival

1995 • 49 citations

Identification and upregulation of galactose/N-acetylgalactosamine macrophage lectin in rat cardiac allografts with arteriosclerosis.

1994 • 48 citations

In vivo studies of P-selectin and platelet activating factor during endotoxemia, accelerated allograft rejection, and discordant xenograft rejection.

1993 • 43 citations

Potential mechanism of abnormal thromboregulation in xenograft rejection: loss of ecto-ATPases upon endothelial cell activation.

1996 • 26 citations

NKG2‐C is a receptor on human natural killer cells that recognizes structures on K562 target cells

1995 • 25 citations

Immunopathology of Discordant Xenograft Rejection

1997 • 17 citations

In vitro and in vivo investigation of anticomplement agents FUT-175 and K76COOH, in the prevention of hyperacute rejection following discordant xenotransplantation in a nonhuman primate model.

1996 • 8 citations

Extended and expanded studies of xenograft rejection in immunodeficient animals.

1994 • 8 citations

Nierentransplantationen

1961 • 6 citations

British, American Reports on Xenotransplantation

1996 • 6 citations