How to get proteomics to the clinic? Issues in clinical proteomics, exemplified by <scp>CE</scp>‐<scp>MS</scp>

Chronic kidney disease: the global challenge

2005 • 1,118 citations

All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan

2008 • 894 citations

Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes

2011 • 742 citations

Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease

2010 • 485 citations

Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis

2006 • 411 citations

Recommendations for Biomarker Identification and Qualification in Clinical Proteomics

2010 • 306 citations

Clinical proteomics: A need to define the field and to begin to set adequate standards

2007 • 304 citations

Urinary Proteomics in Diabetes and CKD

2008 • 273 citations

Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis

2006 • 265 citations

Comparison of Effect Sizes Associated With Biomarkers Reported in Highly Cited Individual Articles and in Subsequent Meta-analyses

2011 • 251 citations

Urinary Proteomics for Early Diagnosis in Diabetic Nephropathy

2012 • 250 citations

CE‐MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics

2008 • 205 citations

Capillary electrophoresis–mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: An update of recent developments

2008 • 188 citations

Implementation of proteomic biomarkers: making it work

2012 • 155 citations

Bile proteomic profiles differentiate cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis

2010 • 155 citations

Urinary Peptidome May Predict Renal Function Decline in Type 1 Diabetes and Microalbuminuria

2009 • 144 citations

Discovery and validation of urinary biomarkers for prostate cancer

2008 • 144 citations

Urinary Proteomics for Prediction of Preeclampsia

2011 • 138 citations

Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals

2010 • 133 citations

Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury

2010 • 126 citations

Human urinary peptide database for multiple disease biomarker discovery

2011 • 112 citations

Identification and Validation of Urinary Biomarkers for Differential Diagnosis and Evaluation of Therapeutic Intervention in Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis

2009 • 111 citations

Evaluation of Urinary Biomarkers for Coronary Artery Disease, Diabetes, and Diabetic Kidney Disease

2009 • 105 citations

Profilin 1 is a Potential Biomarker for Bladder Cancer Aggressiveness

2011 • 104 citations

CE‐MS in biomarker discovery, validation, and clinical application

2010 • 103 citations

High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS

2006 • 96 citations

Identification of a unique urinary biomarker profile in patients with autosomal dominant polycystic kidney disease

2009 • 93 citations

Prediction, progression and prevention of diabetic nephropathy. The Minkowski Lecture 2005

2005 • 93 citations

Capillary electrophoresis coupled to mass spectrometer for automated and robust polypeptide determination in body fluids for clinical use

2004 • 92 citations

Combined Top-Down and Bottom-Up Mass Spectrometric Approach to Characterization of Biomarkers for Renal Disease

2005 • 86 citations

Electrophoretic methods for analysis of urinary polypeptides in IgA‐associated renal diseases

2007 • 83 citations

A comparison between MALDI-MS and CE-MS data for biomarker assessment in chronic kidney diseases

2012 • 64 citations

Urinary proteome analysis identifies infants but not older children requiring pyeloplasty

2010 • 61 citations

Urinary Collagen Fragments Are Significantly Altered in Diabetes: A Link to Pathophysiology

2010 • 59 citations

Non-invasive markers of ureteropelvic junction obstruction

2007 • 58 citations

Common Sense Approaches to Urinary Biomarker Study Design

2009 • 40 citations

A Distinct Urinary Biomarker Pattern Characteristic of Female Fabry Patients That Mirrors Response to Enzyme Replacement Therapy

2011 • 24 citations

The value of newborn urinary proteome analysis in the evaluation and management of ureteropelvic junction obstruction: a cost-effectiveness study

2008 • 22 citations