The Melanocortin Melanocyte-Stimulating Hormone/Adrenocorticotropin_4–10Decreases Body Fat in Humans¹

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Environmental Contributions to the Obesity Epidemic

1998 • 2,243 citations

Assessment of fat-free mass using bioelectrical impedance measurements of the human body

1985 • 1,873 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

1994 • 1,059 citations

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1994 • 1,055 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

1999 • 1,000 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Bioelectrical impedance analysis in body composition measurement: National Institutes of Health Technology Assessment Conference Statement

1996 • 508 citations

Obesity and the Hypothalamus: Novel Peptides for New Pathways

1998 • 448 citations

Several Mutations in the Melanocortin-4 Receptor Gene Including a Nonsense and a Frameshift Mutation Associated with Dominantly Inherited Obesity in Humans

1999 • 439 citations

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

1995 • 361 citations

alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain.

1978 • 352 citations

Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey

1986 • 339 citations

Neuroendocrine Responses to Starvation and Weight Loss

1997 • 270 citations

Usefulness of Bioelectric Impedance and Skinfold Measurements in Predicting Fat-Free Mass Derived from Total Body Potassium in Children

1994 • 263 citations

Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats

1996 • 257 citations

Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus

1998 • 217 citations

Eating Disorders: Progress and Problems

1998 • 199 citations

Identification and functional analysis of novel human melanocortin-4 receptor variants.

1999 • 198 citations

Central nervous system effects of intranasally administered insulin during euglycemia in men.

1999 • 185 citations

A Novel Selective Melanocortin-4 Receptor Agonist Reduces Food Intake in Rats and Mice without Producing Aversive Consequences

2000 • 178 citations

As Obesity Rates Rise, Experts Struggle to Explain Why

1998 • 154 citations

Transneuronal transport of peroxidase-conjugated wheat germ agglutinin (WGA-HRP) from the olfactory epithelium to the brain of the adult rat

1986 • 144 citations

Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus.

1998 • 144 citations

Differential effects of melanocortin peptides on neural melanocortin receptors.

1994 • 127 citations

Uptake of exogenous proteins in mouse olfactory cells

1971 • 104 citations

A nose-brain pathway for psychotropic peptides: evidence from a brain evoked potential study with cholecystokinin

1996 • 84 citations

The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of alpha-MSH

1997 • 70 citations

Penetration of DGAVP (Org 5667) across the blood-brain barrier in human subjects

1987 • 49 citations

Brain Potentials and Attention after Acute and Subchronic Intranasal Administration of ACTH 4–10 and Desacetyl-α-MSH in Humans

1999 • 31 citations

Central actions of ACTH and related peptides

1988 • 31 citations

The behaviorally active peptide ACTH 4-10: Measurement in plasma and pharmacokinetics in man

1988 • 14 citations

α-MSH-like Peptides from the Rat Hypothalamus and Pituitary: Differences in the Degree of N-Acetylation

1984 • 12 citations

Neurokinin‐immunoreactivity in human neuroblastomas

1990 • 9 citations