Thymosin‐α1 and famciclovir combination therapy activates T‐cell response in patients with chronic hepatitis B virus infection in immune‐tolerant phase

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

1981 • 3,549 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

1999 • 1,208 citations

A Randomized, Controlled Trial of Interferon Alfa-2b Alone and after Prednisone Withdrawal for the Treatment of Chronic Hepatitis B

1990 • 855 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B

2000 • 708 citations

Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?

1990 • 578 citations

Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial

2000 • 503 citations

Genotypes, nt 1858 Variants, and Geographic Origin of Hepatitis B Virus—Large‐Scale Analysis Using a New Genotyping Method

1997 • 460 citations

Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.

1998 • 459 citations

Randomized, controlled trial of recombinant human α-interferon in patients with chronic hepatitis B

1988 • 431 citations

Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: New perspectives for immune therapy

2001 • 335 citations

Which patients with chronic hepatitis B virus infection will respond to α-interferon therapy? A statistical analysis of predictive factors

1989 • 306 citations

Different cytokine profiles of intraphepatic T cells in chronic hepatitis B and hepatitis C virus infections

1997 • 306 citations

A controlled trial of interferon with or without prednisone priming for chronic hepatitis B

1992 • 242 citations

A case for cytokines as effector molecules in the resolution of virus infection

1993 • 216 citations

Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B.

1997 • 209 citations

Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B

1997 • 203 citations

Natural history of chronic hepatitis B virus infection in adults with emphasis on the occurrence of cirrhosis and hepatocellular carcinoma

2000 • 197 citations

Combination therapy with lamivudine and famciclovir for chronic hepatitis B–infected Chinese patients: A viral dynamics study

2000 • 171 citations

Branched DNA amplification multimers for the sensitive, direct detection of human hepatitis viruses.

1991 • 170 citations

Chronic Hepatitis B Virus Infection: Treatment Strategies for the Next Millennium

2000 • 170 citations

Clearance of hepatitis B surface antigen after bone marrow transplantation: Role of adoptive immunity transfer

1997 • 167 citations

The serology of chronic hepatitis B infection revisited.

1993 • 165 citations

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1993 • 150 citations

Hepatitis B virus immunopathology

1995 • 142 citations

Modulation of human natural killer cell cytotoxic activity, lymphokine production, and interleukin 2 receptor expression by thymic hormones.

1987 • 138 citations

Thymosin treatment of chronic hepatitis B: A placebo-controlled pilot trial

1991 • 134 citations

Efficacy of thymosin ?1 in patients with chronic hepatitis B: A randomized, controlled trial

1998 • 125 citations

Natural History and Control of Perinatally Acquired Hepatitis B Virus Infection

1992 • 105 citations

Modulation of interleukin 2 receptor expression on normal human lymphocytes by thymic hormones.

1986 • 103 citations

A cell culture assay for compounds which inhibit hepatitis B virus replication

1991 • 103 citations

Virus-Specific Lymphokine Production Differs Quantitatively but Not Qualitatively in Acute and Chronic Hepatitis B Infection

1999 • 100 citations

Prednisolone Priming Enhances Th1 Response and Efficacy of Subsequent Lamivudine Therapy in Patients With Chronic Hepatitis B

2000 • 86 citations

A randomized, placebo-controlled study to evaluate the efficacy of 12-month famciclovir treatment in patients with chronic hepatitis B e antigen–positive hepatitis B

2000 • 79 citations

A randomized controlled trial of thymosin-?1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody?and hepatitis B virus DNA?positive chronic hepatitis B

1996 • 71 citations

Treatment of chronic hepatitis B

1994 • 65 citations

Thymosin α₁ treatment of chronic hepatitis B: results of a phase III multicentre, randomized, double‐blind and placebo‐controlled study

1999 • 56 citations

Famciclovir in chronic hepatitis B: results of a dose-finding study

2000 • 36 citations

Hepatic Expression of Hepatitis B Virus Genome in Chronic Hepatitis B Virus Infection

1996 • 25 citations