Experiences with vaccines against cutaneous leishmaniasis: of men and mice

Two types of mouse helper T-cell clone

1987 • 813 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Identification of an Infective Stage of Leishmania Promastigotes

1984 • 498 citations

New Perspectives on a Subclinical Form of Visceral Leishmaniasis

1986 • 494 citations

Salivary Gland Lysates from the Sand Fly Lutzomyia longipalpis Enhance Leishmania Infectivity

1988 • 454 citations

A Prospective Study of Visceral Leishmaniasis in an Endemic Area of Brazil

1986 • 375 citations

Mucosal leishmaniasis (“spundia” Escomel, 1911)

1986 • 374 citations

Introduction of foreign DNA into mycobacteria using a shuttle phasmid

1987 • 312 citations

An analysis of T cell responsiveness in Indian kala-azar.

1987 • 253 citations

Effective immunization against cutaneous leishmaniasis with defined membrane antigens reconstituted into liposomes.

1988 • 236 citations

MURINE CUTANEOUS LEISHMANIASIS: DISEASE PATTERNS IN INTACT AND NUDE MICE OF VARIOUS GENOTYPES AND EXAMINATION OF SOME DIFFERENCES BETWEEN NORMAL AND INFECTED MACROPHAGES

1979 • 217 citations

Murine cutaneous leishmaniasis : Susceptibility correlates with differential expansion of helper T-cell subsets

1987 • 212 citations

Immunological regulation of experimental cutaneous leishmaniasis. 1. Immunogenetic aspects of susceptibility to Leishmania tvopica in mice

1980 • 207 citations

Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycan.

1988 • 202 citations

Rapid identification of Leishmania species by specific hybridization of kinetoplast DNA in cutaneous lesions.

1982 • 188 citations

IMMUNOTHERAPY VERSUS CHEMOTHERAPY IN LOCALISED CUTANEOUS LEISHMANIASIS

1987 • 173 citations

Molecular cloning of the major surface antigen of leishmania.

1988 • 169 citations

Immunologic regulation of experimental cutaneous leishmaniasis. V. Characterization of effector and specific suppressor T cells.

1982 • 163 citations

Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica.

1980 • 159 citations

LEISHMANIA DONOVANI: AN OPPORTUNISTIC MICROBE ASSOCIATED WITH PROGRESSIVE DISEASE IN THREE IMMUNOCOMPROMISED PATIENTS

1986 • 157 citations

Genetic Control of Natural Resistance to Infection and Malignancy

1980 • 156 citations

Cutaneous leishmaniasis in anti-IgM-treated mice: enhanced resistance due to functional depletion of a B cell-dependent T cell involved in the suppressor pathway.

1984 • 153 citations

Leishmania tropica: Pathogenicity and in vitro macrophage function in strains of inbred mice

1979 • 146 citations

Controlled Field Trials of a Vaccine Against New World Cutaneous Leishmaniasis

1986 • 145 citations

Immunization with Leishmania receptor for macrophages protects mice against cutaneous leishmaniasis.

1985 • 145 citations

Exacerbation of murine cutaneous leishmaniasis by adoptive transfer of parasite-specific helper T cell populations capable of mediating Leishmania major-specific delayed-type hypersensitivity.

1984 • 140 citations

Structure of the major carbohydrate fragment of the Leishmania donovani lipophosphoglycan

1987 • 139 citations

Leishmanial serotypes as distinguished by the gel diffusion of factors excreted in vitro and in vivo.

1972 • 128 citations

Passive transfer of Leishmania lipopolysaccharide confers parasite survival in macrophages.

1986 • 127 citations

T-Cell Responses and Immunity to Experimental Infection with Leishmania Major

1989 • 125 citations

An amphipathic sulphated glycoconjugate of Leishmania: characterization with monoclonal antibodies.

1984 • 125 citations

Growth cycle-dependent generation of complement-resistant Leishmania promastigotes.

1985 • 122 citations

Molecular strategies of parasitic invasion

1986 • 122 citations

Evidence that the major surface proteins of three Leishmania species are structurally related

1985 • 118 citations

Prophylactic immunization against experimental leishmaniasis: I. Protection induced in mice genetically vulnerable to fatal Leishmania tropica infection.

1982 • 118 citations

Increased myelopoiesis during Leishmania major infection in mice: generation of 'safe targets', a possible way to evade the effector immune mechanism.

1986 • 115 citations

Involvement of specific Lyt‐2⁺ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis

1987 • 108 citations

An experimental vaccine against American dermal leishmaniasis: experience in the State of Espírito Santo, Brazil

1985 • 108 citations

Higher frequency of Leishmania major-specific L3T4+ T cells in susceptible BALB/c as compared with resistant CBA mice.

1986 • 104 citations

The present and future of vaccination for cutaneous leishmaniasis.

1980 • 101 citations

Experimental cutaneous leishmaniasis. 3. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica.

1972 • 97 citations

Vaccination against cutaneous leishmaniasis in a murine model. II. Immunologic properties of protective and nonprotective subfractions of soluble promastigote extract.

1987 • 97 citations

Leishmania donovani metacyclic promastigotes: Transformation in vitro, lectin agglutination, complement resistance, and infectivity

1987 • 90 citations

Effects of Promastigote Growth Phase, Frequency of Subculture, and Host Age on Promastigote‐initiated Infections with Leishmania donovani in the Golden Hamster*^†

1974 • 83 citations

Immunotherapy with a mixture of Mycobacterium leprae and BCG in different forms of leprosy and in Mitsuda-negative contacts.

1982 • 83 citations

CUTANEOUS LEISHMANIASIS IN MICE: DISEASE PATTERNS IN RECONSTITUTED NUDE MICE OF SEVERAL GENOTYPES INFECTED WITH LEISHMANIA TROPICA

1980 • 82 citations

Variations in the response of five strains of mice to Leishmania mexicana

1979 • 81 citations

Prophylactic immunization against experimental leishmaniasis. III. Protection against fatal Leishmania tropica infection induced by irradiated promastigotes involves Lyt-1+2- T cells that do not mediate cutaneous DTH.

1984 • 79 citations

Immunology of leishmaniasis.

1971 • 71 citations

Monoclonal antibodies specific for Leishmania tropica. I. Characterization of antigens associated with stage- and species-specific determinants.

1983 • 70 citations

VACCINATION AGAINST CUTANEOUS LEISHMANIASIS IN MICE USING NONPATHOGENIC CLONED PROMASTIGOTES OF LEISHMANIA MAJOR AND IMPORTANCE OF ROUTE OF INJECTION

1984 • 70 citations

Generalized infection and lack of delayed hypersensitivity in BALB/c mice infected with Leishmania tropica major

1979 • 68 citations

Expression and size heterogeneity of a 63 kilodalton membrane glycoprotein during growth and transformation of Leishmania mexicana amazonensis

1986 • 64 citations

Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3

1988 • 62 citations

Increased infectivity of stationary-phase promastigotes of Leishmania donovani: correlation with enhanced C3 binding capacity and CR3-mediated attachment to host macrophages.

1987 • 54 citations

Cutaneous leishmaniasis: The prospects for a killed vaccine

1988 • 53 citations

Biochemical identification of cutaneous leishmanias by analysis of kinetoplast DNA. II. Sequence homologies in Leishmania kDNA

1981 • 52 citations

Systemic infection of Leishmania tropica (major) in various strains of mice

1981 • 47 citations

Receptors and recognition mechanisms of Leishmania species

1985 • 46 citations

The glycoconjugate derived from a Leishmania major receptor for macrophages is a suppressogenic, disease‐promoting antigen in murine cutaneous leishmaniasis

1986 • 45 citations

Leishmaniasis in Brazil: XII. Observations on cross-immunity in monkeys and man infected with Leishmania mexicana mexicana, L. m. amazonensis, L. braziliensis braziliensis, L. b. guyanensis and L. b. panamensis.

1977 • 44 citations

Zoonotic cutaneous leishmaniasis in Saudi Arabia: lesions healing naturally in man followed by a second infection with the same zymodeme of Leishmania major

1985 • 44 citations

Immunoregulatory pathways in murine leishmaniasis: different regulatory control during Leishmania mexicana mexicana and Leishmania major infections.

1985 • 44 citations

Cell-mediated immunity in experimental cutaneous leishmaniasis

1986 • 43 citations

Characterization of in Vitro Proliferative Responses of Human Lymphocytes to Leishmanial Antigens

1979 • 42 citations

Susceptibility to murine cutaneous leishmaniasis correlates with the capacity to generate interleukin 3 in response to leishmania antigen in vitro

1988 • 41 citations

Leishmania major: The suitability of east african nonhuman primates as animal models for cutaneous leishmaniasis

1987 • 41 citations

Studies on the immunology and serology of leishmaniasis II. Cross-immunity experiments among different forms of American cutaneous leishmaniasis in monkeys

1966 • 40 citations

VISCERAL LEISHMANIASIS AS AN OPPORTUNISTIC INFECTION

1986 • 40 citations

New Developments with Human and Veterinary Vaccines

1981 • 40 citations

Host-protective immunity and its suppression in a parasitic disease: murine cutaneous leishmaniasis

1984 • 39 citations

Vaccine-induced immunity against cutaneous leishmaniasis in BALB/c mice

1988 • 33 citations

New Developments with Human and Veterinary Vaccines

1981 • 32 citations

Polyclonal B-cell stimulation by L3T4+ T cells in experimental leishmaniasis

1988 • 31 citations

Leishmania donovani: Cellular and humoral immune responses after primary and challenge infections in squirrel monkeys, Saimiri sciureus

1986 • 29 citations

Studies on visceral Leishmania tropica infection in BALB/c mice. I. Clinical features and cellular changes.

1981 • 26 citations

Immunity: clinical and experimental.

1987 • 26 citations

Effectiveness of Allopurinol against Leishmania Braziliensis Panamensis in Aotus Trivirgatus

1983 • 25 citations

Immune Response to Leishmania

1984 • 23 citations

Leishmania donovani: Clinical, Hematologic and Hepatic Changes in Squirrel Monkeys (Saimiri sciureus)

1985 • 21 citations

Anti-infectious responses in Leishmania major-infected BALB/c mice injected with recombinant granulocyte-macrophage colony stimulating factor

1987 • 20 citations

Heterologous protection in murine cutaneous leishmaniasis

1987 • 18 citations

Susceptibility of Aotus Trivirgatus to Leishmania Braziliensis and L. Mexicana

1981 • 17 citations

Adoptive transfer of delayed type hypersensitivity reactions specific for Leishmania major antigens to normal mice using murine T cell populations and clones generated in vitro.

1984 • 15 citations

Visceral leishmaniasis recrudescence in a patient with AIDS

1987 • 15 citations

Molecular biology of Leishmania

1986 • 14 citations

Inhibition of growth of Leishmania mexicana mexicana by Leishmania mexicana amazonensis during "in vitro" co-cultivation

1987 • 12 citations

Lack of general immunosuppression during visceral Leishmania tropica infection in BALB/c mice: augmented antibody response to thymus-independent antigens and polyclonal activation.

1983 • 12 citations

Une Observation de leishmaniose chez un malade traite par corticoides pour sarcoidose

1987 • 12 citations

Infectivity of Leishmania donovani primary culture promastigotes for golden hamsters. Short communication.

1981 • 11 citations

Resistance and susceptibility of mice to Leishmania major: A view from Melbourne

1987 • 11 citations

A model for the mechanism of sensitivity of BALB/c mice to L. major and premunition in leishmaniases

1987 • 10 citations

Growth curves of Leishmania braziliensis braziliensis Promastigotes and surface antigen expression before and after adaptation to Schneider's drosophila medium as assessed by anti-Leishmania human sera

1988 • 8 citations

The change of behavior of two strains of Leishmania after cultivation in a defined medium

1987 • 7 citations

A marmoset model for some New World dermatotropic leishmaniases.

1988 • 5 citations

Cell Mediated Immunity, Immunodeficiency and Microbial Infections

1989 • 5 citations

[Visceral leishmaniasis associated with positive anti-HTLV III antibody].

1987 • 5 citations

STUDIES ON THE GENETIC CONTROL OF VISCERAL LEISHMANIASIS IN BALB/c MICE BY L.TROPICA

1980 • 5 citations

Comparison of fast (one-step) and interrupted slow cooling methods using a range of intracellular and extracellular cryoprotectants for the freeze-preservation of Plasmodium yoelii-infected mouse erythrocytes

1986 • 5 citations

[Leishmaniasis associated with acquired immunodeficiency syndrome].

1987 • 5 citations

Cell-Mediated Immunity, Immunodeficiency and Microbial Infections

1989 • 1 citations