Evaluation and improvement of bioavailability of a new angiotensin II receptor antagonist, 2-butyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl] methyl-1H-benzimidazole-7-carboxylic acid by making prodrug

Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).

1993 • 211 citations

The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist

1992 • 210 citations

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids

1993 • 128 citations

Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles

1993 • 123 citations

Synthesis and relationship between physicochemical properties and oral absorption of pivaloyloxymethyl esters of parenteral cephalosporins

1985 • 31 citations

Orally active 1-(cyclohexyloxycarbonyloxy)alkyl ester prodrugs of cefotiam.

1987 • 31 citations

Preparation of 1-acyloxyethyl esters of 7-(2-(2-aminothiazol-4-yl)acetamido)-3-(((1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl)thio)methyl)ceph-3-em-4-carboxylic acid (cefotiam) and their oral absorption in mice.

1986 • 21 citations

Synthesis and oral absorption of acyloxymethyl esters of 7β-( 2-( 2-aminothiazol-4-yl) acetamido) -3-(((1-( 2-dimethylaminoethyl) -1H-tetrazol-5-yl) thio) -methyl) ceph-3-em-4-carboxylic acid (cefotiam)

1987 • 13 citations

Imidazole derivatives

1977 • 7 citations

Nonpeptide angiotensin II receptor antagonists: Pharmacological studies on imidazoleacetic acid derivatives

1991 • 5 citations

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