The mechanism of cumene hydroperoxide-dependent lipid peroxidation: The function of cytochrome P-450

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Multiplicity of mammalian microsomal cytochromes P-45.

1979 • 633 citations

ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomes

1963 • 512 citations

Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems

1965 • 503 citations

Microsomes, Drug Oxidations and Chemical Carcinogenesis

1980 • 498 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450

1976 • 339 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats.

1984 • 301 citations

Hydroperoxide‐Metabolizing Systems in Rat Liver

1975 • 266 citations

Hepatic cytochromeP-450 monooxygenase system

1983 • 214 citations

Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines

1973 • 193 citations

Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450

1974 • 173 citations

Purification and characterization of two constitutive forms of rat liver microsomal cytochrome P-450.

1982 • 156 citations

Imidazole antimycotics: Inhibitors of steroid aromatase

1985 • 137 citations

Phenobarbital induction of rat liver cytochromes P-450b and P-450e. Quantitation of specific RNAs by hybridization to synthetic oligodeoxyribonucleotide probes.

1985 • 128 citations

Ketoconazole: a potent inhibitor of cytochrome P-450-dependent drug metabolism in rat liver.

1984 • 123 citations

The Involvement of Cytochrome P-450 in Hepatic Microsomal Steroid Hydroxylation Reactions Supported by Sodium Periodate, Sodium Chlorite, and Organic Hydroperoxides

1976 • 115 citations

Inhibition of rat liver microsomal cytochrome P-450 steroid hydroxylase reactions by imidazole antimycotic agents

1986 • 107 citations

Hydroperoxide dependent O-dealkylation reactions catalyzed by liver microsomal cytochrome P450

1975 • 107 citations

On the mechanism of action of cytochrome P-450. Evaluation of homolytic and heterolytic mechanisms of oxygen-oxygen bond cleavage during substrate hydroxylation by peroxides.

1981 • 99 citations

Possible higher valence states of cytochrome P-450 during oxidative reactions

1974 • 96 citations

Further Studies on Lipid‐Peroxide Formation in Isolated Hepatocytes

1975 • 95 citations

Purification and characterization of a new form (RLM2) of liver microsomal cytochrome P-450 from untreated rat.

1985 • 85 citations

Homolytic and heterolytic oxygen-oxygen bond scissions accompanying oxygen transfer to iron(III) porphyrins by percarboxylic acids and hydroperoxides. A mechanistic criterion for peroxidase and cytochrome P-450

1985 • 81 citations

Differences in the mechanism of NADPH- and cumene hydroperoxide-supported reactions of cytochrome P-450

1980 • 75 citations

Involvement of cytochrome P-450 in the intracellular formation of lipid peroxides

1975 • 73 citations

Mitochondrial lipid peroxidation by cumene hydroperoxide and its prevention by succinate

1982 • 64 citations

Sodium periodate, sodium chlorite, and organic hydroperoxides as hydroxylating agents in steroid hydroxylation reactions catalyzed by adrenocortical microsomal and mitochondrial cytochrome P450

1976 • 62 citations

Radical mechanism of aminopyrine oxidation by cumene hydroperoxide catalyzed by purified liver microsomal cytochrome P-450

1980 • 61 citations

The Consequences of Lipid Peroxidation in Isolated Hepatocytes

1975 • 61 citations

THE CHEMISTRY OF HYDROPEROXIDES. III. THE FREE-RADICAL DECOMPOSITION OF HYDROPEROXIDES

1950 • 52 citations

Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450

1985 • 49 citations

Spin trapping by use of nitroso-compounds. Part IV. Electron spin resonance studies on oxidation with nickel peroxide

1972 • 48 citations

The Mechanism of Action of Cytochrome P-450. Occurrence of the 'NIH Shift' during Hydroperoxide-Dependent Aromatic Hydroxylations

1978 • 47 citations

Ferrous ion-mediated cytochrome P-450 degradation and lipid peroxidation in adrenal cortex mitochondria

1976 • 41 citations

The peroxidatic function of liver microsomal cytochrome P-450: Comparison of hydrogen peroxide and NADPH-catalysed iV-demethylation reactions

1984 • 41 citations

On the mechanism of action of cytochrome P-450. Role of peroxy spectral intermediates in substrate hydroxylation.

1981 • 41 citations

Multiple forms of noninduced rat liver cytochrome P-450. Metabolism of 1-(4'-ethylphenoxy)-3,7-dimethyl-6,7-epoxy-trans-2-octene by reconstituted preparations.

1979 • 40 citations

Interaction of cytochrome P-450 with a hydroperoxide derived from butylated hydroxytoluene. Mechanism of isomerization.

1985 • 35 citations

Competing modes of peroxyacid flux through cytochrome P-450.

1983 • 32 citations

The effect of phenobarbital and carbon tetrachloride on fatty acid content and composition of phospholipids from the endoplasmic reticulum of rat liver

1978 • 30 citations

Hydroperoxysterols as a probe for the mechanism of cytochrome P-450scc-mediated hydroxylation. Homolytic versus heterolytic oxygen-oxygen bond scission.

1986 • 30 citations

The mechanism of cumene hydroperoxide-dependent lipid peroxidation: The significance of oxygen uptake

1986 • 28 citations

Influence of lipid peroxidation on lipoprotein secretion by isolated hepatocytes

1981 • 28 citations

The Role of Cytochrome P‐450 in the Hydroperoxide‐Catalyzed Oxidation of Alcohols by Rat‐Liver Microsomes

1977 • 27 citations

The mitochondrial metabolism of 1,2-disubstituted hydrazines, procarbazine and 1,2-dimethylhydrazine.

1983 • 26 citations

A comparison of NADPH and cumene hydroperoxide-stimulated lipid peroxidation in mouse hepatic microsomes

1981 • 22 citations

Comparative studies on the cumene hydroperoxide- and NADPH-supported N-oxidation of 4-chloroaniline by cytochrome P-450

1983 • 22 citations

Source of the oxygen atom in the product of cytochrome P-450-catalyzed N-demethylation reactions.

1983 • 22 citations

Involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes.

1981 • 20 citations

Cytochrome P-450 mediated interaction between hydroperoxide and molecular oxygen

1983 • 11 citations

Hydroperoxidation by cytochrome P-450 oxygenase: Metabolism of 9-methylfluorene

1985 • 2 citations

Cumene hydroperoxide effected hydroperoxidation by cytochrome P-450

1985 • 2 citations

Deleted Work

1955 • 0 citations

Cited By (0)

Loading...