Inappropriate use of albino animals as models in research

Harrison's Principles of Internal Medicine.

1988 • 11,687 citations

The Metabolic Basis of Inherited Disease

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THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

1969 • 1,680 citations

The Migration and Differentiation of Neural Crest Cells

1970 • 814 citations

Harrison's Principles of Internal Medicine 16th ed

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A new syndrome combining developmental anomalies of the eyelids, eyebrows and nose root with pigmentary defects of the iris and head hair and with congenital deafness.

1951 • 627 citations

The neurocristopathiesA unifying concept of disease arising in neural crest maldevelopment

1974 • 591 citations

Contributions to behavior-genetic analysis : the mouse as a prototype

1970 • 462 citations

Uncrossed Visual Pathways of Hooded and Albino Rats

1965 • 449 citations

Amorphous Semiconductor Switching in Melanins

1974 • 436 citations

A syndrome associating partial albinism and immunodeficiency

1978 • 372 citations

Comparative genetics of coat colour in mammals.

1968 • 367 citations

Plasma amino acids in patients with hepatic encephalopathy

1974 • 303 citations

The primary optic projections in the rabbit. An experimental degeneration study

1969 • 267 citations

ADDISON'S DISEASE – CLINICAL STUDIES. A REPORT OF 108 CASES

1974 • 261 citations

Aberrant visual projections in the Siamese cat

1971 • 254 citations

The free radical property of melanins

1960 • 244 citations

A study of normal and congenitally abnormal retinogeniculate projections in cats

1971 • 241 citations

The Ototoxicity of Chloroquine Phosphate

1964 • 229 citations

Genetic control of morphogenetic and biochemical differentiation: Lethal albino deletions in the mouse

1979 • 221 citations

The diffuse neuroendocrine system and the apud concept: related "endocrine" peptides in brain, intestine, pituitary, placenta, and anuran cutaneous glands.

1977 • 215 citations

Retinogeniculate projections in hooded and albino rats: An autoradiographic study

1976 • 210 citations

Physiological control of brain norepinephrine synthesis by brain tyrosine concentration

1978 • 209 citations

An abnormal retinogeniculate projection in Siamese cats

1969 • 205 citations

Abnormal visual pathways in the brain of a human albino

1975 • 188 citations

The number of myelinated and unmyelinated fibers in the optic nerve of vertebrates

1942 • 187 citations

Deafness as Part of an Hereditary Syndrome

1959 • 187 citations

Genetic control of retinal ganglion cell projections

1978 • 176 citations

Visual System Anomalies in Human Ocular Albinos

1978 • 173 citations

Asymmetric visually evoked potentials in human albinos: evidence for visual system anomalies.

1974 • 168 citations

Anaemia in gastroenterology

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The albino rat: A defensible choice or a bad habit?

1968 • 161 citations

Visual Pathways in Albinos

1974 • 151 citations

Accumulation of drugs on melanin.

1973 • 149 citations

Pigmentation of the Stria Vascularis The Contribution of Neural Crest Melanocytes

1977 • 140 citations

Congenitally abnormal visual pathways in mink (Mustela vison) with reduced retinal pigment

1974 • 135 citations

Genetics of the Norway rat

1965 • 130 citations

Observations on the histological features, development and pathogenesis of the inner ear degeneration of the deaf white cat

1965 • 122 citations

Retinal Recovery from Exposure to Light

1970 • 122 citations

White Fur, Blue Eyes, and Deafness in the Domestic Cat

1971 • 116 citations

The relationship between abnormalities of pigmentation and of the inner ear

1970 • 111 citations

On the origin of the free radical property of melanins

1960 • 109 citations

An abnormal retinogeniculate projection in the albino ferret (Mustela furo)

1971 • 107 citations

The association of Waardenburg syndrome and Hirschsprung megacolon

1979 • 104 citations

Optokinetic Eye Movements in Albino Rabbits: Inversion in Anterior Visual Field

1978 • 100 citations

Embryogenesis of the enteric ganglia in normal mice and in mice that develop congenital aganglionic megacolon

1973 • 98 citations

Partial Albinism and Deaf Mutism

1962 • 98 citations

Interocular transfer of brightness and pattern discriminations in normal and corpus callosum-sectioned rats.

1965 • 92 citations

Differences in visually evoked responses in albino versus hoded rats

1970 • 87 citations

Genetic Abnormality of the Visual Pathways in a "White" Tiger

1973 • 86 citations

Visual System Anomaly associated with Albinism in the Cat

1971 • 85 citations

Heritable aspects of anomalous myelinated fibre tracts in the forebrain of the laboratory mouse

1974 • 85 citations

Melanogenesis in cultures of peripheral nervous tissue

1977 • 81 citations

The Degradation of the Photoreceptor Outer Segment within the Pigment Epithelial Cell of Rat Retina<xref ref-type="fn" rid="fn1"><sup>*</sup></xref>

1970 • 78 citations

Schmidt's Syndrome (Thyroid and Adrenal Insufficiency): A Review of the Literature and a Report of Fifteen New Cases Including Ten Instances of Coexistent Diabetes Mellitus

1964 • 76 citations

Salicylate: Action on Normal Body Temperature in Rats

1972 • 72 citations

Gene action and behavior: An evaluation of major gene pleiotropism.

1969 • 72 citations

Domestication.

1973 • 72 citations

Melanogenesis in cultures of peripheral nervous tissue

1977 • 67 citations

Retinogeniculate projections in albino and ocularly hypopigmented rats

1976 • 66 citations

THE ASSOCIATION OF THE BLACK (non-agouti) GENE WITH BEHAVIOR

1942 • 63 citations

Congenital Deafness Associated With Piebaldness

1965 • 63 citations

Mutants with Abnormal Visual Pathways: An Explanation of Anomalous Geniculate Laminae

1971 • 63 citations

The development of piebald spotting in mice

1965 • 62 citations

Differential effects of ethanol and pentobarbital on sleep time in C57BL and BALB mice.

1974 • 62 citations

The primary optic projections in pigmented and albino guinea pigs: an experimental degeneration study

1973 • 61 citations

The influence of age, sex and drug treatment on microsomal drug metabolism in four rat strains

1969 • 60 citations

A New Hereditary Syndrome – Sex-linked Deaf-mutism Associated with Total Albinism

1962 • 59 citations

Retinogeniculostriate projections in guinea pigs: Albino and pigmented strains compared

1972 • 55 citations

Animal model of human disease: Chédiak-Higashi syndrome.

1978 • 49 citations

STUDIES ON MEGACOLON IN PIEBALD MICE

1962 • 46 citations

Pilocarpine Uptake by Pigmented Uveal Tissue

1973 • 43 citations

Primary Neural Disorders in the Deaf White Cat Cochlea

1977 • 42 citations

Barbiturate dependence in mice induced by a simple short-term oral procedure

1973 • 40 citations

Pilocarpine levels in the eyes of rabbits following topical application

1975 • 36 citations

Marked Differences between Pigmented and Albino Rabbits in the Concentration of Clindamycin in Iris and Choroid-Retina

1979 • 36 citations

Distribution of an 125I-labelled chloroquine analogue in a pregnant macaca monkey

1975 • 34 citations

Distribution of Labeled Chloroquine in the Inner Ear

1975 • 34 citations

Effects of constant illumination on vision in the albino rat

1977 • 33 citations

Electroretinographic Measurement of the Spectral Sensitivity in Albinos, Caucasians, and Negroes

1959 • 33 citations

Effects of a 60‐Hz magnetic field on activity levels of mice

1977 • 33 citations

Light-induced alterations of retinal pigment epithelium in black, albino, and beige mice

1976 • 32 citations

Albinism and auditory function in the laboratory mouse. I. Effects of single-gene substitutions on auditory physiology, audiogenic seizures, and developmental processes

1975 • 31 citations

Differences of ipsilateral and contralateral visually evoked responses in the cat: Strains compared.

1971 • 27 citations

Identification of a membrane protein binding the retinol in retinal pigment epithelium

1977 • 27 citations

Enhancement of melanocyte development from piebald neural crest by a favorable tissue environment

1977 • 26 citations

Altered response latencies on visual discrimination tasks in rats with damaged retinas☆

1974 • 26 citations

Competitive Binding between Cocaine and Various Drugs to Synthetic Levodopa Melanin

1977 • 25 citations

Melanin, Adrenalin and the Legacy of Fear

1970 • 24 citations

Contributions of the genes albinism (c) and retinal degeneration (rd) to a strain-by-training procedure interaction in avoidance learning

1973 • 23 citations

The photically evoked afterdischarge: Current concepts and potential applications

1978 • 23 citations

Pigmentary Retinopathy of Myotonic Dystrophy

1971 • 23 citations

Oculocutaneous Albinism and Mental Disorder

1978 • 23 citations

Genetically determined abnormalities of microsomal enzymes in liver of mutant newborn mice

1976 • 21 citations

Strain differences in the elicitation of electrocortical after-discharges

1973 • 20 citations

Ototoxic Drugs: A Review of Clinical Aspects, Histopathologic Changes and Mechanisms of Action

1971 • 19 citations

Differences in optokinetic nystagmus between albino and pigmented rabbits

1977 • 18 citations

Inherited eye diseases.

1975 • 18 citations

Autoradiography of intravenously injected 14C-nicotine indicates long-term retention in the respiratory tract.

1974 • 18 citations

Deficiency in plasma protein synthesis caused by x-ray-incuded lethal albino alleles in mouse.

1976 • 17 citations

Strain differences in the response of rats to repeated injections of pentobarbital sodium.

1973 • 16 citations

Stock and sex specificity in the response of rats to pentobarbital sodium.

1968 • 15 citations

Drug‐induced ectothermia in small mammals: The quest for a biological microwave dosimeter

1977 • 15 citations

Differences in Microsomal Enzyme Induction between Sprague-Dawley and Long-Evans Rats

1972 • 15 citations

The Electroretinogram of Albino and Pigmented Rabbits

1974 • 14 citations

Glutamine synthetase in newborn mice homozygous for lethal albino alleles

1975 • 13 citations

Additional Evidence on the Inheritance of Cyclic Neutropenia in the Dog

1970 • 13 citations

Luminance-onset, pattern-onset and pattern-reversal evoked potentials in human albinos demonstrating visual system anomalies

1979 • 13 citations

Waardenburg syndrome with a fixed dilated pupil.

1978 • 12 citations

The slow ERG potentials in hereditary retinal dystrophy of albino and pigmented rats

1976 • 12 citations

Differences in cytochrome P-450 of various strains of rats following chronic administration of pentobarbital

1976 • 11 citations

Relation of albinism and drugs to the visual evoked potential of the mouse.

1978 • 11 citations

Effects of increasing dose levels of pentobarbital on visually evoked responses of albino and pigmented rats.

1974 • 10 citations

Note on the Colour Changes in Rats' Fur Produced by Alterations in Diet

1923 • 9 citations

Effect of a coat color locus on kidney lysosomal glycosidases in the house mouse

1977 • 9 citations

The motor nerves of the eye in albino and gray Norway rats

1934 • 9 citations

Effects of ambient lighting and the albino gene on the developing visual evoked potential of the mouse

1977 • 8 citations

The skin in genetically-controlled metabolic disorders.

1973 • 8 citations

Response to pentobarbital of pigmented vs albino C57BL/6J-c2J mice: A within-strain comparison of sleeptimes and lethal doses

1979 • 8 citations

Chediak-Higashi Syndrome

2022 • 8 citations

Strain differences in lateralization of acoustic priming for susceptibility to audiogenic seizures

1979 • 6 citations

A new, albino-beige mouse: giant granules in retinal pigment epithelium.

1978 • 6 citations

Animal models of albinism.

1976 • 4 citations

Biochemical aspects of human albinism.

1976 • 4 citations

Color dilution in the gray collie.

1974 • 4 citations

Deficient brightness discrimination in hooded but not albino rats given neocortical ablations

1973 • 4 citations

A comparative study on tyrosine metabolism in livers of albino & black mice.

1976 • 1 citations