Ascorbate and phenolic antioxidant interactions in prevention of liposomal oxidation

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?

1983 • 800 citations

Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols

1985 • 769 citations

Vesicles of variable diameter prepared by a modified injection method

1977 • 585 citations

Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C.

1984 • 580 citations

Vitamin E: Interactions with Free Radicals and Ascorbate

1985 • 527 citations

Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes

1985 • 428 citations

Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C

1990 • 321 citations

Will antioxidant nutrients slow aging processes?

1968 • 279 citations

Studies of ascorbate-dependent, iron-catalyzed lipid peroxidation

1989 • 257 citations

Biokinetics of and discrimination between dietaryRRR‐ andSRR‐α‐tocopherols in the male rat

1987 • 256 citations

An investigation into thee mechanism of citrateFE2+-dependent lipid peroxidation

1987 • 245 citations

Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.

1991 • 228 citations

Vitamin E dependent reduced glutathione inhibition of rat liver microsomal lipid peroxidation

1982 • 146 citations

Oxidation of vitamin E: evidence for competing autoxidation and peroxyl radical trapping reactions of the tocopheroxyl radical

1990 • 124 citations

Antioxidant activity of probucol and its analogs in hypercholesterolemic Watanabe rabbits

1991 • 116 citations

Stopped-flow investigation of the reaction of vitamin C with tocopheroxyl radical in aqueous triton X-100 micellar solutions. The structure-activity relationship of the regeneration reaction of tocopherol by vitamin C.

1991 • 108 citations

Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation.

1989 • 107 citations

Mitochondria and microsomal membranes have a free radical reductase activity that prevents chromanoxyl radical accumulation

1989 • 98 citations

Generation and recycling of radicals from phenolic antioxidants

1990 • 92 citations

Mechanisms of stabilization of biomembranes by alpha-tocopherol

1990 • 80 citations

A cardioselective, hydrophilic N,N,N-trimethylethanaminium .alpha.-tocopherol analog that reduces myocardial infarct size

1991 • 70 citations

The effect of glutathione on the vitamin E requirement for inhibition of liver microsomal lipid peroxidation

1990 • 68 citations

Redox cycles of vitamin E: hydrolysis and ascorbic acid dependent reduction of 8a-(alkyldioxy)tocopherones

1989 • 61 citations

Action of vitamin E as antioxidant in phospholipid liposomal membranes as studied by spin label technique.

1988 • 60 citations

Peroxyl radical trapping and autoxidation reactions of .alpha.-tocopherol in lipid bilayers

1991 • 51 citations

Characterization of glutathione-dependent inhibition of lipid peroxidation of isolated rat liver nuclei

1988 • 51 citations

Reactions of biological antioxidants: III. Composition of biological membranes

1971 • 32 citations

Modification of hepatic vitamin E stores in vivo

1991 • 30 citations

Kinetic study of the reaction of vitamin C with vitamin E radicals (tocopheroxyls) in solution

1989 • 27 citations

Synthesis and hypocholesterolemic activity of alkylidenedithio bisphenols

1970 • 27 citations

Bromosulfophthalein abolishes glutathione dependent protection against lipid peroxidation in rat liver mitochondria

1987 • 11 citations

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