Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

Heat shock, from bacteria to man

1982 • 1,260 citations

Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

1989 • 933 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

1986 • 704 citations

Regulation of protein synthesis during heat shock

1981 • 451 citations

The Neostriatal Mosaic: Striatal Patch-Matrix Organization Is Related to Cortical Lamination

1989 • 450 citations

Synaptic loss in Alzheimer's disease and other dementias

1989 • 406 citations

Translational control of protein synthesis in response to heat shock in D. melanogaster cells

1980 • 356 citations

Regulation of protein synthesis in HeLa cells: Translation at elevated temperatures

1969 • 302 citations

MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE

1989 • 266 citations

Expression of heat shock proteins in Alzheimer's disease

1991 • 251 citations

Decreased levels of protein kinase C in Alzheimer brain

1988 • 242 citations

REFERENCE: REFERENCES

1975 • 203 citations

Translational control in lysates of Drosophila melanogaster cells.

1981 • 167 citations

Phosphorylated Neurofilament Antigens in Neurofibrillary Tangles in Alzheimerʼs Disease

1986 • 158 citations

31P Nuclear Magnetic Resonance Studies of Phosphoglyceride Metabolism in Developing and Degenerating Brain

1987 • 158 citations

Alzheimer's disease-associated reduction of polysomal mRNA translation

1989 • 113 citations

Aberrant casein kinase II in Alzheimer's disease

1990 • 107 citations

Stress-induced proteins

1988 • 100 citations

Elsie 4: Quantitative computer analysis of sets of two-dimensional gel electrophoretograms

1988 • 85 citations

Characterization of Messenger RNA from the Cerebral Cortex of Control and Alzheimer‐Afflicted Brain

1986 • 80 citations

Differential brain expression of the Alzheimer's amyloid precursor protein.

1989 • 75 citations

Alterations of transcription and translation in HeLa cells exposed to amino acid analogs.

1984 • 56 citations

Reduced in vitro phosphorylation of synapsin I (site 1) in Alzheimer's disease postmortem tissues

1991 • 38 citations

Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease.

1986 • 33 citations

Meningeal carcinomatosis

1988 • 33 citations

Glial fibrillary acidic protein and Alzheimer's disease

1985 • 32 citations

Exploration of the upper atmosphere and ionosphere of Mars

1981 • 16 citations

Characterization of polysomes purified from human postmortem brain tissues

1990 • 6 citations