Response to myocardial ischemia as a regulated process.

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Reversibility of Cardiac Wall-Motion Abnormalities Predicted by Positron Tomography

1986 • 1,306 citations

The hibernating myocardium

1989 • 1,256 citations

Experimental Subendocardial Ischemia in Dogs with Normal Coronary Arteries

1972 • 833 citations

Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode.

1990 • 777 citations

Reversible ischemic left ventricular dysfunction: Evidence for the “hibernating myocardium”

1986 • 733 citations

Localized Disorders in Myocardial Contraction

1967 • 625 citations

A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina.

1985 • 589 citations

Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts.

1984 • 572 citations

Myocardial contractile function during ischemia and hypoxia.

1987 • 486 citations

Studies of acidosis in the ischaemic heart by phosphorus nuclear magnetic resonance

1979 • 479 citations

Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation.

1991 • 423 citations

Pressure-flow relations in coronary circulation

1990 • 393 citations

Correlation between acute reductions in myocardial blood flow and function in conscious dogs.

1980 • 380 citations

Control of Coronary Blood Flow by an Autoregulatory Mechanism

1964 • 374 citations

Functional compartmentation of ATP and creatine phosphate in heart muscle

1970 • 301 citations

Four brief periods of myocardial ischemia cause no cumulative ATP loss or necrosis

1986 • 281 citations

Compensatory changes of the distal coronary vascular bed during progressive coronary constriction.

1975 • 247 citations

A quantitative study of the anatomy and distribution of coronary arteries in swine in comparison with other animals and man

1986 • 245 citations

Early Changes in Energy Metabolism in the Myocardium Following Acute Coronary Artery Occlusion in Anesthetized Dogs

1968 • 236 citations

Significance of regional wall thickening abnormalities relative to transmural myocardial perfusion in anesthetized dogs.

1980 • 233 citations

Determinants and prediction of transmural myocardial perfusion.

1978 • 233 citations

Immediate improvement of dysfunctional myocardial segments after coronary revascularization: Detection by intraoperative transesophageal echocardiography

1984 • 226 citations

Transmural myocardial perfusion

1987 • 219 citations

The effects of cardiac sympathetic nerve stimulation on perfusion of stenotic coronary arteries in the dog.

1983 • 216 citations

Regional myocardial perfusion and wall thickening during ischemia in conscious dogs

1984 • 216 citations

Myocardial ATP synthesis and mechanical function following oxygen deficiency

1978 • 213 citations

Influence of Aortocoronary Bypass Surgery on Left Ventricular Performance

1971 • 204 citations

Prolonged myocardial nucleotide depletion after brief ischemia in the open-chest dog

1982 • 198 citations

Detection of Residual Myocardial Function in Coronary Artery Disease Using Post-extra Systolic Potentiation

1974 • 197 citations

Mechanism of early “pump” failure of the ischemic heart: Possible role of adenosine triphosphate depletion and inorganic phosphate accumulation

1977 • 194 citations

Reversible asynergy. Histopathologic and electrographic correlations in patients with coronary artery disease.

1976 • 179 citations

Improved regional ventricular function after successful surgical revascularization

1984 • 176 citations

Improved Myocardial Function during Exercise after Successful Percutaneous Transluminal Coronary Angioplasty

1982 • 171 citations

The role of autoregulation and tissue diastolic pressures in the transmural distribution of left ventricular blood flow in anesthetized dogs.

1979 • 171 citations

Significance of subendocardial S-T segment elevation caused by coronary stenosis in the dog

1977 • 169 citations

The Experimental Production of Intercoronary Arterial Anastomoses and their Functional Significance

1950 • 164 citations

Coronary pressure-function and steady-state pressure-flow relations during autoregulation in the unanesthetized dog.

1988 • 160 citations

Heterogeneity of the hypoxic state in perfused rat heart.

1977 • 160 citations

Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve.

1985 • 155 citations

Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis.

1988 • 153 citations

Effect of exercise on the relationship between myocardial blood flow and systolic wall thickening in dogs with acute coronary stenosis.

1983 • 150 citations

Regeneration of myocardial phosphocreatine in pigs despite continued moderate ischemia.

1990 • 149 citations

Effect of coronary constriction on myocardial distribution of iodoantipyrine-131-I

1968 • 127 citations

Active downregulation of myocardial energy requirements during prolonged moderate ischemia in swine.

1991 • 123 citations

Coronary microvascular responses to reductions in perfusion pressure. Evidence for persistent arteriolar vasomotor tone during coronary hypoperfusion.

1990 • 115 citations

Persistence of coronary vasodilator reserve despite functionally significant flow reduction

1985 • 109 citations

Cellular mechanism of the modulation of contractile function by coronary perfusion pressure in ferret hearts.

1989 • 108 citations

Transmural differences in ventricular tissue substrate levels due to coronary constriction

1972 • 105 citations

Progressive coronary vasoconstriction during relative ischemia in canine myocardium.

1982 • 92 citations

Myocardial contractile force as a function of coronary blood flow

1976 • 91 citations

Repetitive episodes of brief ischaemia (12 min) do not produce a cumulative depletion of high energy phosphate compounds

1984 • 84 citations

Transmural differences in sympathetic coronary constriction during exercise in the presence of coronary stenosis.

1988 • 84 citations

Fate of Left Ventricular Contraction following Aortocoronary Venous Grafts

1972 • 81 citations

Myocardial lactate release during ischemia in swine. Relation to regional blood flow.

1990 • 81 citations

Incomplete coronary vasodilation during myocardial ischemia in swine

1985 • 77 citations

Relation between contractile reserve and prognosis in patients with coronary artery disease and a depressed ejection fraction.

1975 • 76 citations

Improvement of myocardial perfusion and left ventricular function after coronary artery bypass grafting in patients with unstable angina.

1979 • 74 citations

Adrenergic vasoconstriction lessens transmural steal during coronary hypoperfusion

1986 • 65 citations

Transmural gradients of left ventricular tissue metabolites after circumflex artery ligation in dogs

1977 • 64 citations

Effects of pressure gradients between branches of the left coronary artery on the pressure axis intercept and the shape of steady state circumflex pressure-flow relations in dogs.

1985 • 64 citations

Reversible segmental left ventricular dysfunction after coronary angioplasty.

1990 • 62 citations

Biochemical mechanisms of acute contractile failure in the hypoxic rat heart

1986 • 59 citations

Myocardial hibernation in the ischemic neonatal heart.

1990 • 57 citations

Nonuniform loss of regional flow reserve during myocardial ischemia in dogs.

1990 • 56 citations

Transmural coronary flow reserve patterns in dogs

1986 • 55 citations

Effects of interrupted coronary flow upon myocardial metabolism and contractility

1968 • 54 citations

Response of myocardial metabolites to graded regional ischemia: 31P NMR spectroscopy of porcine myocardium in vivo.

1989 • 52 citations

Acute changes in global and regional rest left ventricular function after successful coronary angioplasty: Comparative results in stable and unstable angina

1989 • 47 citations

Correlation of contractile dysfunction with oxidative energy production and tissue high energy phosphate stores during partial coronary flow disruption in rabbit heart.

1988 • 44 citations

Segment stroke work and metabolism depend on coronary blood flow in the pig

1978 • 43 citations

Regional myocardial energetics during brief periods of coronary occlusion and reperfusion: comparison with S-T segment changes

1978 • 42 citations

Stabilization of a derangement in adenosine triphosphate metabolism during sustained, partial ischemia in the dog heart

1986 • 39 citations

Myocardial energy production and consumption remain balanced during positive inotropic stimulation when coronary flow is restricted to basal rates in rabbit heart.

1987 • 21 citations

Loss of regional ventricular postextrasystolic potentiation after coronary occlusion in dogs

1977 • 20 citations

Persistent right coronary flow reserve at low perfusion pressure

1989 • 19 citations

Reversible and Irreversible Depression of Ischemic Myocardium

1972 • 17 citations

Transmural Myocardial Perfusion

1990 • 5 citations

Importance of vasomotor tone to myocardial function and regional metabolism during constant flow ischaemia in swine

1990 • 5 citations