Growth hormone (GH) treatment of GH-deficient children increases serum levels of insulin-like growth factors (IGFs), IGF-binding protein-3 and -5, and bone alkaline phosphatase isoenzyme.

Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.

1981 • 595 citations

Bone Growth Factors

2001 • 483 citations

A Specific Radioimmunoassay for the Growth Hormone (GH)-Dependent Somatomedin-Binding Protein: Its Use for Diagnosis of GH Deficiency

1990 • 460 citations

Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action.

1992 • 351 citations

Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men.

1994 • 251 citations

Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women.

1994 • 248 citations

Primary structure of human skeletal growth factor: homology with human insulin-like growth factor-II

1988 • 204 citations

Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: A potential candidate for fixing IGF-II in human bone

1991 • 169 citations

The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women.

1995 • 152 citations

Regulation and biological effect of endogenous insulin-like growth factor binding protein-5 in human osteoblastic cells.

1993 • 145 citations

Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases.

1994 • 132 citations

Complex pattern of insulin‐like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E₂, growth hormone, and the insulin‐like growth factors

1994 • 126 citations

Basal and regulated secretion of insulin-like growth factor binding proteins in osteoblast-like cells is cell line specific.

1992 • 104 citations

Short-Term Changes in Serum Insulin-Like Growth Factors (IGF) and IGF Binding Protein 3 after Different Modes of Intravenous Growth Hormone (GH) Exposure in GH-Deficient Patients

1991 • 102 citations

Changes in insulin-like growth factor-I (IGF-I), IGF-binding protein-3, growth hormone (GH)-binding protein, erythrocyte IGF-I receptors, and growth rate during GH treatment.

1995 • 49 citations

Evidence that human bone cells in culture secrete insulin-like growth factor (IGF)-II and IGF binding protein-3 but not acid-labile subunit both under basal and regulated conditions

1995 • 38 citations

Systemic administration of rhIGF-I or rhIGF-I/IGFBP-3 increases cortical bone and lean body mass in ovariectomized rats

1995 • 37 citations

Growth Hormone Stimulates Cortical Bone Formation in Immature Hypophysectomized Rats

1992 • 25 citations

Recombinant Dna-Derived Human Insulin-Like Growth Factor II (hIGF-II) Stimulates Growth in Hypophysectomized Rats

1989 • 16 citations

Cited By (0)

Loading...