Bipolar Depression

Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States

1994 • 12,456 citations

Suicide as an outcome for mental disorders

1997 • 2,553 citations

A Double-Blind Placebo-Controlled Study of Lamotrigine Monotherapy in Outpatients With Bipolar I Depression

1999 • 1,056 citations

The National Depressive and Manic-depressive Association (DMDA) survey of bipolar members

1994 • 909 citations

Efficacy of Divalproex vs Lithium and Placebo in the Treatment of Mania

1994 • 872 citations

A Randomized, Placebo-Controlled 12-Month Trial of Divalproex and Lithium in Treatment of Outpatients With Bipolar I Disorder

2000 • 683 citations

The enduring psychosocial consequences of mania and depression

1993 • 661 citations

Family Factors and the Course of Bipolar Affective Disorder

1988 • 611 citations

Antidepressant-induced mania and cycle acceleration: a controversy revisited

1995 • 600 citations

Practice guideline for the treatment of patients with bipolar disorder. American Psychiatric Association

1994 • 592 citations

Randomised controlled trial of efficacy of teaching patients with bipolar disorder to identify early symptoms of relapse and obtain treatment

1999 • 589 citations

Olanzapine Versus Placebo in the Treatment of Acute Mania

1999 • 580 citations

Drug Therapy in the Prevention of Recurrences in Unipolar and Bipolar Affective Disorders

1984 • 569 citations

Efficacy of Olanzapine in Acute Bipolar Mania<subtitle>A Double-blind, Placebo-Controlled Study</subtitle>

2000 • 557 citations

Carbamazepine in manic-depressive illness: a new treatment

1980 • 485 citations

Triiodothyronine Augmentation in the Treatment of Refractory Depression

1996 • 483 citations

Induction of Mania with Selective Serotonin Re-uptake Inhibitors and Tricyclic Antidepressants

1994 • 476 citations

12-Month Outcome of Patients With Bipolar Disorder Following Hospitalization for a Manic or Mixed Episode

1998 • 459 citations

A Placebo-Controlled Study of Lamotrigine and Gabapentin Monotherapy in Refractory Mood Disorders

2000 • 455 citations

Family-focused treatment of bipolar disorder: 1-year effects of a psychoeducational program in conjunction with pharmacotherapy

2000 • 452 citations

Lithium Carbonate and Imipramine in Prevention of Affective Episodes

1973 • 450 citations

Course of the Manic-Depressive Cycle and Changes Caused by Treatments

2008 • 445 citations

Can antidepressants cause mania and worsen the course of affective illness?

1987 • 408 citations

Risk of Recurrence Following Discontinuation of Lithium Treatment in Bipolar Disorder

1991 • 394 citations

The longitudinal course of recurrent affective illness: Life chart data from research patients at the NIMH

1985 • 392 citations

Double-Blind, Placebo-Controlled Comparison of Imipramine and Paroxetine in the Treatment of Bipolar Depression

2001 • 392 citations

Tranylcypromine versus imipramine in anergic bipolar depression

1991 • 364 citations

The pharmacological treatment of delusional depression

1985 • 356 citations

Gabapentin in bipolar disorder: a placebo‐controlled trial of adjunctive therapy1

2000 • 318 citations

Comparative Prophylactic Efficacy of Lithium, Carbamazepine, and the Combination in Bipolar Disorder

1997 • 313 citations

Evidence of the Dual Mechanisms of Action of Venlafaxine

2000 • 297 citations

Differential outcome of pure manic, mixed/cycling, and pure depressive episodes in patients with bipolar illness

1986 • 289 citations

MAOIs in the Contemporary Treatment of Depression

1995 • 287 citations

A double-blind trial of bupropion versus desipramine for bipolar depression.

1994 • 281 citations

Lithium versus carbamazepine in the maintenance treatment of bipolar disorders – a randomised study

1997 • 260 citations

The clinical features of bipolar depression: a comparison with matched major depressive disorder patients.

2001 • 258 citations

A Comparison of Fluoxetine Imipramine and Placebo in Patients with Bipolar Depressive Disorder

1989 • 256 citations

Medication resistance and clinical response to electroconvulsive therapy

1990 • 251 citations

Rapid Cycling Bipolar Affective Disorder

1990 • 250 citations

Risperidone Augmentation of Selective Serotonin Reuptake Inhibitors in Major Depression

1999 • 249 citations

Preventing medical noncompliance in the outpatient treatment of bipolar affective disorders.

1984 • 244 citations

Preventing medical noncompliance in the outpatient treatment of bipolar affective disorders.

1984 • 242 citations

Antidepressant effects of carbamazepine

1986 • 241 citations

Catecholamine metabolism in affective disorders—III

1970 • 239 citations

Safety Review of Adult Clinical Trial Experience with Lamotrigine

1998 • 226 citations

Risperidone Treatment for Juvenile Bipolar Disorder: A Retrospective Chart Review

1999 • 226 citations

Lithium Response in Unipolar Versus Bipolar Depression

1972 • 222 citations

The Clinical Features of Bipolar Depression

2001 • 213 citations

Lithium carbonate treatment in depression and mania

1969 • 210 citations

Double-Blind Comparison of Addition of a Second Mood Stabilizer Versus an Antidepressant to an Initial Mood Stabilizer for Treatment of Patients With Bipolar Depression

2000 • 209 citations

Substance P and the Neurokinins: Novel Peptide Neurotransmitters in Psychopharmacology

1999 • 208 citations

Suicidality in patients with pure and depressive mania

1994 • 206 citations

Effects of Psychoeducational Intervention for Married Patients with Bipolar Disorder and Their Spouses

1998 • 193 citations

Clinical Outcome in a Randomized 1-Year Trial of Clozapine Versus Treatment as Usual for Patients With Treatment-Resistant Illness and a History of Mania

2003 • 193 citations

Treatment of depression in bipolar disorder: new directions for research.

1993 • 191 citations

Newer Antiepileptic Drugs in Bipolar Disorder

2002 • 191 citations

Lithium Maintenance Treatment of Depression and Mania in Bipolar I and Bipolar II Disorders

1998 • 183 citations

EFFICACY OF LITHIUM AS ACUTE TREATMENT OF MANIC-DEPRESSIVE ILLNESS

1971 • 180 citations

Suicidality, panic disorder and psychosis in bipolar depression, depressive-mania and pure-mania

1997 • 178 citations

A Prospective Safety Surveillance Study for Bupropion Sustained-Release in the Treatment of Depression

1998 • 178 citations

ECT in bipolar and unipolar depression: differences in speed of response

2001 • 175 citations

Suicidality among patients with mixed and manic bipolar disorder

1996 • 174 citations

Efficacy and Safety of Fluoxetine in Treating Bipolar II Major Depressive Episode

1998 • 173 citations

Columbia Atypical Depression

1993 • 173 citations

Differential Outcome of Pure Manic, Mixed/Cycling, and Pure Depressive Episodes in Patients With Bipolar Illness

1986 • 172 citations

Treatment of imipramine-resistant recurrent depression, IV: A double- blind crossover study of tranylcypromine for anergic bipolar depression

1992 • 171 citations

Lithium Maintenance: 1. A Standard Education Programme for Patients

1991 • 170 citations

Lithium in the treatment of depression

1976 • 164 citations

Psychotic (delusional) depression: a meta-analysis of physical treatments

1992 • 163 citations

Valproate in psychiatric disorders: literature review and clinical guidelines.

1989 • 161 citations

WARTIME CHANGES IN HOSPITAL ADMISSIONS FOR SCHIZOPHRENIA

1966 • 161 citations

Rapid cycling manic depressive patients

1977 • 160 citations

The Anticonvulsant Lamotrigine in Treatment-Resistant Manic-Depressive Illness

1997 • 159 citations

The place of anticonvulsant therapy in bipolar illness

1996 • 157 citations

Meta-Analysis of the Reversible Inhibitors of Monoamine Oxidase Type A Moclobemide and Brofaromine for the Treatment of Depression

1999 • 157 citations

Lithium Carbonate Response in Depression

1975 • 156 citations

A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants

1990 • 156 citations

Bipolar depression: pharmacotherapy and related therapeutic strategies

2000 • 154 citations

The Induction of Mania

1982 • 153 citations

The Use of Lithium in Affective Disorders: I. Acute Endogenous Depression

1968 • 152 citations

Double-Blind Comparison of Bupropion Sustained Release and Sertraline in Depressed Outpatients

1997 • 152 citations

A randomized clinical trial of inpatient family intervention V. results for affective disorders

1990 • 151 citations

Spectrum of Efficacy of Valproate in 78 Rapid-Cycling Bipolar Patients

1992 • 149 citations

Prophylactic Lithium Carbonate With and Without Imipramine for Bipolar 1 Patients

1981 • 146 citations

Bipolar Depression and Antidepressant-Induced Mania

1998 • 145 citations

Treatment of Depression in Bipolar Disorder

1993 • 141 citations

Nefazodone

1997 • 141 citations

Benzodiazepines as antidepressants: Does GABA play a role in depression?

1995 • 139 citations

Recent trends in the use of antidepressant drugs in Australia, 1990–1998

2000 • 132 citations

Dr. Wehr and Associates Reply

1987 • 127 citations

The Impact of Antidepressant Discontinuation Versus Antidepressant Continuation on 1-Year Risk for Relapse of Bipolar Depression

2001 • 127 citations

Bipolar depression: An underestimated treatment challenge

1997 • 118 citations

Efficacy and Safety of Venlafaxine in the Treatment of Bipolar II Major Depressive Episode

1998 • 118 citations

An open study of lamotrigine in refractory bipolar depression

1997 • 118 citations

Have some guidelines for the treatment of acute bipolar depression gone too far in the restriction of antidepressants?

2000 • 117 citations

Efficacy and tolerability of reboxetine compared with imipramine in a double-blind study in patients suffering from major depressive episodes

1997 • 116 citations

Cognitive Therapy for Bipolar Depression: A Pilot Study

1999 • 113 citations

TREATMENT OF PREVIOUSLY INTRACTABLE DEPRESSIONS WITH TRANYLCYPROMINE AND LITHIUM

1972 • 110 citations

Double-blind comparison of bupropion and fluoxetine in depressed outpatients.

1991 • 109 citations

Efficacy and Tolerability of Moclobemide Compared with Imipramine in Depressive Disorder (DSM-III): An Austrian Double-blind, Multicentre Study∗

1989 • 107 citations

Comparison of Bupropion and Trazodone for the Treatment of Major Depression

1994 • 107 citations

Clinical predictors of acute risperidone response in schizophrenia, schizoaffective disorder, and psychotic mood disorders.

1995 • 104 citations

A Double-Blind Study of Tranylcypromine Treatment of Major Anergic Depression

1982 • 103 citations

TREATMENT-RESISTANT BIPOLAR DEPRESSION

1996 • 102 citations

Long-Term Olanzapine Therapy in the Treatment of Bipolar I Disorder

2001 • 100 citations

Adjunctive psychotherapy for bipolar disorder: Effects of changing treatment modality.

1999 • 99 citations

Mood-stabilisers reduce the risk of developing antidepressant-induced maniform states in acute treatment of bipolar I depressed patients

2001 • 99 citations

Bupropion as a promising approach to rapid cycling bipolar II patients.

1990 • 99 citations

Venlafaxine monotherapy in women with bipolar II and unipolar major depression

2000 • 95 citations

Moclobemide vs. imipramine in bipolar depression: a multicentre double‐blindclinical trial

2001 • 94 citations

Association Between Lower Serum Free T₄ and Greater Mood Instability and Depression in Lithium-Maintained Bipolar Patients

1999 • 93 citations

The Expert Consensus Guidelines for treating depression in bipolar disorder.

1998 • 91 citations

The treatment of bipolar depression.

2000 • 89 citations

Lithium treatment of depression

1974 • 88 citations

Efficacy of moclobemide in different patient groups: a meta-analysis of studies

1992 • 88 citations

Inpatient Family Intervention: A Randomized Clinical Trial

1988 • 87 citations

Adjunctive psychotherapy for bipolar disorder: Effects of changing treatment modality.

1999 • 87 citations

The Addition of Lithium to Carbamazepine

1989 • 84 citations

Divalproex therapy in medication-naive and mood-stabilizer-naive bipolar II depression

2001 • 84 citations

On intrapair differences in male twins with special reference on dominance-submissiveness.

1966 • 83 citations

Identification of the neural systems subserving the actions of clozapine: clues from immediate-early gene expression.

1994 • 83 citations

Social anxiety, hypomania and the bipolar spectrum: data, theory and clinical issues

1998 • 83 citations

Long-term risperidone treatment in bipolar disorder

1997 • 80 citations

Acute Treatment of Bipolar Disorder with Adjunctive Risperidone in Outpatients

1997 • 77 citations

Treatment strategy in depression

1988 • 76 citations

Controlled trials in bipolar I depression: focus on switch rates and efficacy

1999 • 75 citations

New Concepts in Mood Stabilization: Evidence for the Effectiveness of Valproate and Lamotrigine

1998 • 74 citations

Prediction of antidepressant responses to lithium

1978 • 72 citations

Somatic Treatment of Psychotic Depression: Review and Recommendations for Practice

2000 • 67 citations

Bupropion in the treatment of bipolar disorders: the same old story?

1992 • 66 citations

Antidepressant-associated maniform states in acute treatment of patients with bipolar-I depression

1998 • 63 citations

Treatment of bipolar depression with carbamazepine: Results of an open study

1996 • 62 citations

Fluoxetine Treatment of Bipolar II Depression

1991 • 61 citations

Possible Interaction between Fluoxetine and Pimozide Causing Sinus Bradycardia

1993 • 60 citations

Lamotrigine in the treatment of bipolar depression

1999 • 58 citations

The Expanding Pharmacopoeia for Bipolar Disorder

2002 • 57 citations

Phenomenology of rapid cycling manic depression and its treatment with valproate.

1989 • 57 citations

Bipolar depression: treatment options.

1997 • 56 citations

Antidepressants and suicidal risk.

1999 • 51 citations

Efficacy in long-term treatment of depression.

1996 • 51 citations

Treatment of Acute Bipolar Depression: A Review of the Literature

1995 • 50 citations

Meta‐analysis of randomized, double‐blind, dacebo‐controlled, efficacy and safety studies of mirtazapine versus amitripcyline in major depression

1997 • 47 citations

A multicenter evaluation of bupropion versus placebo in hospitalized depressed patients.

1983 • 47 citations

Polarity Sequence, Depression, and Chronicity in Bipolar I Disorder

1999 • 45 citations

Paroxetine and Amitriptyline Augmentation of Lithium in the Treatment of Major Depression

1999 • 42 citations

Mood stabilizers and the evolution of maintenance study designs in bipolar I disorder.

1999 • 41 citations

Novel treatments for bipolar disorder

2001 • 38 citations

Initial lithium augmentation improves the antidepressant effects of standard TCA treatment in non-resistant depressed patients

1995 • 38 citations

Treating Bipolar Illness: Focus on Treatment Algorithms and Management of the Sleep-Wake Cycle

1999 • 38 citations

On defining ‘mood stabilizer’

2001 • 37 citations

Mixed mania: Apparent induction by a tricyclic antidepressant in five consecutively treated patients with bipolar depression

1995 • 36 citations

‘Why Getting Fat, Doc?’ Weight Gain and Psychotropic Medications

2001 • 36 citations

Bupropion in the long-term treatment of cyclic mood disorders: mood stabilizing effects.

1985 • 36 citations

Does olanzapine have antidepressant properties? A retrospective preliminary study

2000 • 35 citations

Bupropion's prophylactic efficacy in bipolar affective illness.

1983 • 33 citations

Addition of monoamine oxidase inhibitors to carbamazepine: preliminary evidence of safety and antidepressant efficacy in treatment-resistant depression.

1995 • 31 citations

Fluvoxamine and lithium in long-term treatment of unipolar subjects with high recurrence rate

1996 • 30 citations

Sociodemographic and prior clinical course characteristics associated with treatment response in depressed patients

1988 • 30 citations

Lithium augmentation of antidepressants in treatment-refractory depression.

1998 • 29 citations

Bipolar depression: specific treatments.

1998 • 29 citations

Treatment guidelines for valproate in bipolar and schizoaffective disorders.

1993 • 28 citations

Are Atypical Antipsychotic Drugs also Atypical Antidepressants?

2001 • 27 citations

Mood-stabilizing drugs in depression.

1999 • 26 citations

Alternative approaches to refractory depression in bipolar illness

1997 • 25 citations

The use of bupropion in hospitalized depressed patients.

1983 • 25 citations

Nimodipine in human alcohol withdrawal syndrome — an open study

1990 • 25 citations

The induction of mania: a natural history study with controls.

1987 • 24 citations

Depressive mania: Response of residual depression to bupropion

1994 • 15 citations

Melancholia and Response to ECT

1995 • 12 citations

An investigation of primary care patients receiving extended treatment with selective serotonin reuptake inhibitors.

1998 • 8 citations

P.1.110 A double-blind multicentre trial of moclobemide vs imipramine in bipolar depression

1997 • 7 citations

Topics in contemporary psychiatric practice: Diagnosing Bipolar Disorder

2001 • 1 citations

Deleted Work

1955 • 0 citations