Live oral cholera vaccine : from principle to product

Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans.

1988 • 703 citations

New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development

1983 • 573 citations

Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions.

1991 • 570 citations

Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up

1990 • 497 citations

ENDEMIC CHOLERA IN RURAL BANGLADESH, 1966–1980

1982 • 358 citations

FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

1986 • 353 citations

M Cell Transport of Vibrio cholerae from the Intestinal. Lumen into Peyer's Patches: A Mechanism for Antigen Sampling and for Microbial Transepithelial Migration

1986 • 349 citations

SAFETY, IMMUNOGENICITY, AND EFFICACY OF RECOMBINANT LIVE ORAL CHOLERA VACCINES, CVD 103 AND CVD 103-HgR

1988 • 318 citations

Volunteer studies of deletion mutants of Vibrio cholerae O1 prepared by recombinant techniques

1988 • 295 citations

Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette.

1993 • 275 citations

Duration of Infection-Derived Immunity to Cholera

1981 • 255 citations

Enterotoxicity of El Tor-like hemolysin of non-O1 Vibrio cholerae

1987 • 203 citations

Recombinant nontoxinogenic Vibrio cholerae strains as attenuated cholera vaccine candidates

1984 • 198 citations

Seroepidemiological Studies of EI Tor Cholera in Bangladesh: Association of Serum Antibody Levels with Protection

1985 • 193 citations

Immunity of cholera in man: Relative role of antibacterial versus antitoxic immunity

1979 • 180 citations

Safety and immunogenicity of single-dose live oral cholera vaccine CVD 103-HgR in 5-9-year-old Indonesian children

1992 • 155 citations

Oral fluid therapy of cholera among Bangladesh refugees.

1973 • 150 citations

Onset and Duration of Protective Immunity in Challenged Volunteers after Vaccination with Live Oral Cholera Vaccine CVD l03-HgR

1992 • 142 citations

Purification and characterization of a hemolysin produced by Vibrio cholerae biotype El Tor: another toxic substance produced by cholera vibrios

1979 • 142 citations

The relationship of vibriocidal antibody titre to susceptibility to cholera in family contacts of cholera patients.

1968 • 142 citations

Safety and Immunogenicity of Different Immunization Regimens of CVD 103-HgR Live Oral Cholera Vaccine in Soldiers and Civilians in Thailand

1992 • 116 citations

Safety, immunogenicity, and excretion pattern of single-dose live oral cholera vaccine CVD 103-HgR in Peruvian adults of high and low socioeconomic levels

1993 • 114 citations

Acute enteric infections in children - new prospects for treatment and prevention

1982 • 110 citations

Live oral vaccines against cholera: An update

1993 • 105 citations

Initial Clinical Studies of CVD 112 Vibrio cholerae O139 Live Oral Vaccine: Safety and Efficacy against Experimental Challenge

1995 • 103 citations

A serological survey for cholear antibodies in rural east Pakistan. 1. The distribution of antibody in the control population of a cholera-vaccine field-trial area and the relation of antibody titre to the pattern of endemic cholera.

1968 • 102 citations

A Recombinant Live Oral Cholera Vaccine

1984 • 98 citations

Safety and Immunogenicity of Live Oral Cholera Vaccine Candidate CVD 110, a ctxA ctxAzot zotace Derivative of El Tor Ogawa Vibrio cholerae

1993 • 93 citations

Field Trial of Oral Cholera Vaccines in Bangladesh: Serum Vibriocidal and Antitoxic Antibodies as Markers of the Risk of Cholera

1991 • 93 citations

Safety and immunogenicity in North Americans of a single dose of live oral cholera vaccine CVD 103-HgR: results of a randomized, placebo-controlled, double-blind crossover trial

1992 • 90 citations

Safety, Immunogenicity, and Transmissibility of Single-Dose Live Oral Cholera Vaccine Strain CVD l03-HgR in 24- to 59-Month-Old Indonesian Children

1993 • 85 citations

Immunity and Vaccine Development

1992 • 85 citations

Randomized double-blind placebo controlled trial to evaluate the safety and immunogenicity of the live oral cholera vaccine strain CVD 103-HgR in Swiss adults

1990 • 79 citations

Biotype as determinant of natural immunising effect of cholera

1991 • 73 citations

Clinical and Immunologic Characteristics of Vibrio cholerae O139 Bengal Infection in North American Volunteers

1995 • 72 citations

CVD110, an attenuated Vibrio cholerae O1 El Tor live oral vaccine strain

1993 • 58 citations

Attenuated live cholera vaccine strain CVD 103-HgR elicits significantly higher serum vibriocidal antibody titers in persons of blood group O

1995 • 58 citations

Acute enteric infections in Children: New prospects for treatment and prevention

1983 • 57 citations

Molecular and clinical aspects of bacterial vaccine development

1995 • 57 citations

Preliminary assessment of the safety and immunogenicity of live oral cholera vaccine strain CVD 103-HgR in healthy Thai adults

1989 • 56 citations

Construction of genetically markedVibrio choleraeO1 vaccine strains

1993 • 52 citations

Isolation and characterization of a cytolysin produced by Vibrio cholerae serogroup non-O1

1985 • 48 citations

Immunogenicity of Vibrio cholerae O1 toxin-coregulated pili in experimental and clinical cholera

1991 • 47 citations

Recombinant attenuated Vibrio cholerae strains used as live oral vaccines

1990 • 46 citations

Secondary Vibrio cholerae-specific cellular antibody responses following wild-type homologous challenge in people vaccinated with CVD 103-HgR live oral cholera vaccine: changes with time and lack of correlation with protection

1993 • 44 citations

Safety and immunogenicity of a live oral bivalent typhoid fever (Salmonella typhi Ty21a)-cholera (Vibrio cholerae CVD 103-HgR) vaccine in healthy adults

1995 • 41 citations

Potential for reacquisition of cholera enterotoxin genes by attenuated Vibrio cholerae vaccine strain CVD 103-HgR

1994 • 38 citations

Safety and immunogenicity of a booster dose of Vibrio cholerae CVD 103-HgR live oral cholera vaccine in Swiss adults

1992 • 37 citations

Kinetics of the vibriocidal antibody response to live oral cholera vaccines

1994 • 30 citations

Survival and multiplication of Vibrio cholerae in the upper bowel of infant mice

1978 • 20 citations

[Tolerance and immunogenicity of an oral dose of CVD 103-HgR, a live attenuated Vibrio cholerae 01 strain: a double-blind study of Chilean adults].

1993 • 17 citations

Molecular and clinical aspects of bacterial vaccine development

1996 • 11 citations

Nonlipopolysaccharide Protective Antigens Shared by Classical and EI Tor Biotypes of Vibrio cholerae

1987 • 11 citations

Vibriocidal antibody and antibodies to Vibrio cholerae lipopolysaccharide, cell-bound haemagglutinin and toxin in Thai population.

1986 • 10 citations

Correlation between worm burden and schistosome pigment in the liver of mice experimentally infected with Schistosoma mansoni.

1968 • 3 citations