Quasispecies Theory in Virology

Selforganization of matter and the evolution of biological macromolecules

1971 • 3,737 citations

The Hypercycle: A principle of natural self-organization

1979 • 1,983 citations

A principle of natural self-organization

1977 • 1,695 citations

Rapid Evolution of RNA Genomes

1982 • 1,475 citations

RNA virus error catastrophe: Direct molecular test by using ribavirin

2001 • 819 citations

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

2000 • 812 citations

Encyclopedia of virology

1999 • 791 citations

Molecular quasi-species

1988 • 661 citations

Nucleotide sequence heterogeneity of an RNA phage population

1978 • 557 citations

RNA Virus Populations as Quasispecies

1992 • 523 citations

Origin and evolution of viruses.

1998 • 519 citations

Fitness of RNA virus decreased by Muller's ratchet

1990 • 498 citations

Introduction To Artificial Life

1998 • 422 citations

Self-replication with errors

1982 • 360 citations

Lethal mutagenesis of HIV with mutagenic nucleoside analogs

1999 • 356 citations

Error thresholds of replication in finite populations mutation frequencies and the onset of muller's ratchet

1989 • 278 citations

Exponential increases of RNA virus fitness during large population transmissions.

1995 • 278 citations

Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

1990 • 256 citations

Response of Foot-and-Mouth Disease Virus to Increased Mutagenesis: Influence of Viral Load and Fitness in Loss of Infectivity

2000 • 225 citations

What is a quasispecies?

1992 • 195 citations

Memory in Viral Quasispecies

2000 • 187 citations

RNA virus quasispecies populations can suppress vastly superior mutant progeny

1990 • 186 citations

Transition between Stochastic Evolution and Deterministic Evolution in the Presence of Selection: General Theory and Application to Virology

2001 • 181 citations

Hepatitis C Virus Resistance to Antiviral Therapy

2000 • 143 citations

Subclonal components of consensus fitness in an RNA virus clone

1994 • 139 citations

The evolution of HIV

1999 • 134 citations

Evolutionarily Related Sindbis-Like Plant Viruses Maintain Different Levels of Population Diversity in a Common Host

2000 • 127 citations

Natural selection: a phase transition?

2000 • 89 citations

Molecular intermediates of fitness gain of an RNA virus: characterization of a mutant spectrum by biological and molecular cloning

2001 • 87 citations

Genetic Diversity of RNA Viruses

1992 • 83 citations

Reproducible Nonlinear Population Dynamics and Critical Points During Replicative Competitions of RNA Virus Quasispecies

1996 • 70 citations

Foot-and-Mouth Disease Virus Lacking the VP1 G-H Loop: The Mutant Spectrum Uncovers Interactions among Antigenic Sites for Fitness Gain

2001 • 49 citations

Contingent Neutrality in Competing Viral Populations

2001 • 44 citations

Nature and evolution of early replicons

1999 • 34 citations

Mutation, Competition, and Selection as Measured with Small RNA Molecules

2008 • 17 citations

Microbial ecology: Organisms, habitats, activities

1989 • 15 citations