Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

1995 • 93,704 citations

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2004 • 9,201 citations

DAVID: Database for Annotation, Visualization, and Integrated Discovery

2003 • 8,668 citations

EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

2004 • 4,293 citations

Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks

2006 • 3,397 citations

Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers

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Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer

2007 • 2,249 citations

Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways

2004 • 1,600 citations

KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

2005 • 1,510 citations

Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies

2007 • 910 citations

Phosphorylation of β-Catenin by AKT Promotes β-Catenin Transcriptional Activity

2007 • 794 citations

Phosphotyrosine interactome of the ErbB‐receptor kinase family

2005 • 731 citations

Clinical Course of Patients with Non–Small Cell Lung Cancer and Epidermal Growth Factor Receptor Exon 19 and Exon 21 Mutations Treated with Gefitinib or Erlotinib

2006 • 720 citations

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

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A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling

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Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

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Advances to Bayesian network inference for generating causal networks from observational biological data

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Immortalization of Human Bronchial Epithelial Cells in the Absence of Viral Oncoproteins

2004 • 640 citations

Exon 19 Deletion Mutations of Epidermal Growth Factor Receptor Are Associated with Prolonged Survival in Non–Small Cell Lung Cancer Patients Treated with Gefitinib or Erlotinib

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Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation

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Time-resolved Mass Spectrometry of Tyrosine Phosphorylation Sites in the Epidermal Growth Factor Receptor Signaling Network Reveals Dynamic Modules

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Signaling networks assembled by oncogenic EGFR and c-Met

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Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor orto down-regulation of the receptors

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The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

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Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface

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Multiple Oncogenic Changes (K-RASV12, p53 Knockdown,Mutant EGFRs, p16Bypass, Telomerase) Are Not Sufficient to Confer a Full Malignant Phenotype on Human Bronchial Epithelial Cells

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A Critical Role of Cavin (Polymerase I and Transcript Release Factor) in Caveolae Formation and Organization

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Effects of HER2 overexpression on cell signaling networks governing proliferation and migration

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Phosphoproteomic analysis of Her2/neu signaling and inhibition

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Quantitative proteomics using stable isotope labeling with amino acids in cell culture

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Epidermal Growth Factor–Independent Transformation of Ba/F3 Cells with Cancer-Derived Epidermal Growth Factor Receptor Mutants Induces Gefitinib-Sensitive Cell Cycle Progression

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Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes

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Evidence that MIG-6 is a tumor-suppressor gene

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A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells

1997 • 120 citations

ErbB-β-Catenin Complexes Are Associated with Human Infiltrating Ductal Breast and Murine Mammary Tumor Virus (MMTV)-Wnt-1 and MMTV-c-Neu Transgenic Carcinomas

2002 • 77 citations

Systematic Mapping of Potential Binding Sites for Shc and Grb2 SH2 Domains on Insulin Receptor Substrate-1 and the Receptors for Insulin, Epidermal Growth Factor, Platelet-derived Growth Factor, and Fibroblast Growth Factor

1996 • 66 citations